REXO1_YEAST - dbPTM
REXO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID REXO1_YEAST
UniProt AC P53331
Protein Name RNA exonuclease 1
Gene Name RNH70
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 553
Subcellular Localization Nucleus .
Protein Description 3' exoribonuclease required for 5S rRNA maturation and for the proper maturation of the 5' cistron of the tRNA-Arg3 dicistronic gene. Involved with REX2 in the maturation of the 5.8S rRNA, and with REX2 and REX3, in the 3' processing of the U5L snRNA..
Protein Sequence MQVEGPDTNFVSDLALGSKKRRLSKTSVQEDDHTNVVSEVNKNKKKKKAKPMTCTLLKSVVEKGIGIKDVRDMTQYLLQAENNSPKWIDICNRSSLQKMIVLFIPGLQPDDFENGKNTFNEISDDNFKYIPGEIASTFHTFPVMAPGSKMTLFSPYNSFINVGLSKMEKINKLKELQKKKKITINDLVLSEQQLVANDYPLDSGDTNFDTDWVQTVDFTHGGSHIFALDCEMCLSEQGLVLTRISLVNFDNEVIYEELVKPDVPIVDYLTRYSGITEEKLTVGAKKTLREVQKDLLKIISRSDILIGHSLQNDLKVMKLKHPLVVDTAIIYHHKAGDPFKPSLKYLSETFLNKSIQNGEHDSVEDARACLELTKLKILNGLAFGIGINTENLFTKLHRFEVKTVLLNDMIIKNHTEDDSKGQLIRCVEDDETWTHIHENLNKDVKLIVGRIKNLERSRNYNKKPRKETPSFDASMVLHDIGQHLTQLYENATPGTMILIMSGTGDTRPWNNLSTELEFIQDKKERLDKRREREPEIVEAIKLARGGVASFTVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationGSKKRRLSKTSVQED
CCCCCCCCCCCCCCC		31.8821440633
26PhosphorylationKKRRLSKTSVQEDDH
CCCCCCCCCCCCCCC		30.6522369663
27PhosphorylationKRRLSKTSVQEDDHT
CCCCCCCCCCCCCCC		26.0722369663
34PhosphorylationSVQEDDHTNVVSEVN
CCCCCCCCCHHHHHH		36.3828889911
50UbiquitinationNKKKKKAKPMTCTLL
CCCCCCCCCCCHHHH		44.1723749301
53PhosphorylationKKKAKPMTCTLLKSV
CCCCCCCCHHHHHHH		15.7423749301
55PhosphorylationKAKPMTCTLLKSVVE
CCCCCCHHHHHHHHH		26.4227738172
58UbiquitinationPMTCTLLKSVVEKGI
CCCHHHHHHHHHCCC		44.3023749301
74PhosphorylationIKDVRDMTQYLLQAE
CCCHHHHHHHHHHHC		20.5329734811
287PhosphorylationLTVGAKKTLREVQKD
CCCCCHHHHHHHHHH		30.2719795423
549PhosphorylationLARGGVASFTVK---
HHHCCEEEEEEC---		21.0230377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of REXO1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of REXO1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of REXO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ORN_YEASTREX2genetic
10716935
REXO3_YEASTREX3genetic
10716935
RRS1_YEASTRRS1genetic
16100378
LHP1_YEASTLHP1genetic
18456844
RRP1_YEASTRRP1genetic
18456844
LSM3_YEASTLSM3genetic
19061648
ERF3_YEASTSUP35genetic
19061648
POP8_YEASTPOP8genetic
19061648
POP7_YEASTPOP7genetic
19061648
ARC1_YEASTARC1genetic
19061648
RPC9_YEASTRPC17genetic
19061648
POP1_YEASTPOP1genetic
19061648
LSM7_YEASTLSM7genetic
19061648
BRR1_YEASTBRR1genetic
19061648
DBR1_YEASTDBR1genetic
19061648
DBP5_YEASTDBP5genetic
19061648
TGS1_YEASTTGS1genetic
19061648
PEX32_YEASTPEX32genetic
20093466
STE50_YEASTSTE50genetic
20093466
UME6_YEASTUME6genetic
20093466
BUD27_YEASTBUD27genetic
20093466
LRP1_YEASTLRP1genetic
20093466
NUC1_YEASTNUC1genetic
20093466
RS21B_YEASTRPS21Bgenetic
20093466
SFGH_YEASTYJL068Cgenetic
20093466
XPOT_YEASTLOS1genetic
20093466
YPT6_YEASTYPT6genetic
20093466
BRR1_YEASTBRR1genetic
20093466
RRP6_YEASTRRP6genetic
24224060
TFC3_YEASTTFC3genetic
27708008
POP7_YEASTPOP7genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPC10_YEASTRPC11genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PRP28_YEASTPRP28genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SAD1_YEASTSAD1genetic
27708008
IPI1_YEASTIPI1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
RPC9_YEASTRPC17genetic
27708008
TAD3_YEASTTAD3genetic
27708008
PRP24_YEASTPRP24genetic
27708008
NOP2_YEASTNOP2genetic
27708008
TRM6_YEASTGCD10genetic
27708008
RPC6_YEASTRPC34genetic
27708008
RPC1_YEASTRPO31genetic
27708008
RPAB3_YEASTRPB8genetic
27708008
RRS1_YEASTRRS1genetic
27708008
TFC8_YEASTTFC8genetic
27708008
TIM50_YEASTTIM50genetic
27708008
PRP4_YEASTPRP4genetic
27708008
SWD1_YEASTSWD1genetic
27708008
PEX32_YEASTPEX32genetic
27708008
UME6_YEASTUME6genetic
27708008
UBP3_YEASTUBP3genetic
27708008
LRP1_YEASTLRP1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
NUC1_YEASTNUC1genetic
27708008
XPOT_YEASTLOS1genetic
27708008
YPT6_YEASTYPT6genetic
27708008
UBX2_YEASTUBX2genetic
27708008
TMA23_YEASTTMA23genetic
27708008
LSM7_YEASTLSM7genetic
27708008
RRP6_YEASTRRP6genetic
27708008
BRR1_YEASTBRR1genetic
27708008
DHYS_HUMANDHPSphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of REXO1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, AND MASSSPECTROMETRY.

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