dbPTM

REXO3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	REXO3_YEAST
UniProt AC	Q12090
Protein Name	RNA exonuclease 3
Gene Name	REX3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	404
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA..
Protein Sequence	MGSLLRPVDLVNQPLGFQERYKILQKLFKQLQKAYAHTKGTNIDLERLATRLEVHVAKNSLSGQSYKFNMSILLRDVLKYKGDLSKIKINGRPLKGAKPHLSSIGNANSITTKSKAMEALKALILDSKVLEKNGYIVKEMQNKTNDDNSTQLYAPCLRCSSNFKKTDIMEKTLCRYHPLKRIYNRDTKNHQYPCCGETTDSVSFLRLGCKTFFHHVFRGESYDELCKISKFSSTDDIDGVENVLSLDCEMAFTSLGYEMIRLTIVDFFTGKTLFDHVIQPIGDIVDLNSDFSGVHEIDRTNCPTYKEALDVFLSENLINKNSILIGHGLENDLNVMRLFHNKVIDTAILYSRTKFKVSLKNLAFEVLSRKIQNGEHDSSQDAIATMDVVKVKIGISPSQNKWEK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Acetylation	ERYKILQKLFKQLQK HHHHHHHHHHHHHHH	53.07	24489116
60	Phosphorylation	EVHVAKNSLSGQSYK HHEECCCCCCCCCEE	24.17	28889911
221	Phosphorylation	HHVFRGESYDELCKI HHHHCCCCHHHHHHH	40.48	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of REXO3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of REXO3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of REXO3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAD3_YEAST	TAD3	genetic	19061648
ERF3_YEAST	SUP35	genetic	19061648
POP8_YEAST	POP8	genetic	19061648
ISY1_YEAST	ISY1	genetic	19061648
BRR1_YEAST	BRR1	genetic	19061648
FBRL_YEAST	NOP1	genetic	19061648
PRP9_YEAST	PRP9	genetic	27708008
PRP11_YEAST	PRP11	genetic	27708008
NSE4_YEAST	NSE4	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
MAK21_YEAST	MAK21	genetic	27708008
PDC2_YEAST	PDC2	genetic	27708008
SLU7_YEAST	SLU7	genetic	27708008
SNU56_YEAST	SNU56	genetic	27708008
TRS23_YEAST	TRS23	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
FCF1_YEAST	FCF1	genetic	27708008
RPB7_YEAST	RPB7	genetic	27708008
SYF1_YEAST	SYF1	genetic	27708008
SMT3_YEAST	SMT3	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
PRP43_YEAST	PRP43	genetic	27708008
XPO1_YEAST	CRM1	genetic	27708008
DNA2_YEAST	DNA2	genetic	27708008
SLN1_YEAST	SLN1	genetic	27708008
RRN7_YEAST	RRN7	genetic	27708008
MTR4_YEAST	MTR4	genetic	27708008
HACD_YEAST	PHS1	genetic	27708008
PRP21_YEAST	PRP21	genetic	27708008
ESS1_YEAST	ESS1	genetic	27708008
SEN1_YEAST	SEN1	genetic	27708008
LCB1_YEAST	LCB1	genetic	27708008
DPOA_YEAST	POL1	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of REXO3_YEAST

Related Literatures of Post-Translational Modification