YO093_YEAST - dbPTM
YO093_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YO093_YEAST
UniProt AC Q12275
Protein Name Uncharacterized protein YOR093C
Gene Name YOR093C
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1648
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MDFSIPPTLPLDLQSRLNELIQDYKDENLTRKGYETKRKQLLDKFEISQMRPYTPLRSPNSRKSKHLHRRNTSLASSITSLPNSIDRRHSIYRVTTINSTSANNTPRRRSKRYTASLQSSLPGSSDENGSVKDAVYNPMIPLLPRHTGAENTSSGDSAMTDSLPLILRGRFEHYDGQTAMISINSKGKETFITWDKLYLKAERVAHELNKSHLYKMDKILLWYNKNDVIEFTIALLGCFISGMAAVPVSFETYSLREILEIIKVTNSKFVLISNACHRQLDNLYSSSNHSKVKLVKNDVFQQIKFVKTDDLGTYTKAKKTSPTFDIPNISYIEFTRTPLGRLSGVVMKHNILINQFETMTKILNSRSMPHWKQKSQSIRKPFHKKIMATNSRFVILNSLDPTRSTGLIMGVLFNLFTGNLMISIDSSILQRPGGYENIIDKFRADILLNDQLQLKQVVINYLENPESAFSKKHKIDFSCIKSCLTSCTTIDTDVSEMVVHKWLKNLGCIDAPFCYSPMLTLLDFGGIFISIRDQLGNLENFPIHNSKLRLQNELFINREKLKLNEVECSITAMINSSSSFKDYLKLETFGFPIPDITLCVVNPDTNTLVQDLTVGEIWISSNHITDEFYQMDKVNEFVFKAKLNYSEMFSWAKYEMPTNEKSQAVTEQLDTILNICPANTYFMRTKLMGFVHNGKIYVLSLIEDMFLQNRLIRLPNWAHTSNLLYAKKGNQSAQPKGNTGAESTKAIDISSLSGETSSGYKRVVESHYLQQITETVVRTVNTVFEVAAFELQHHKEEHFLVMVVESSLAKTEEESKNGETTDTTLMKFAETQRNKLETKMNDLTDQIFRILWIFHKIQPMCILVVPRDTLPRRYCSLELANSTVEKKFLNNDLSAQFVKFQFDNVILDFLPHSAYYNESILSEHLSKLRKMALQEEYAMIEPAYRNGGPVKPKLALQCSGVDYRDESVDTRSHTKLTDFKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVHKKVSWASFGKIVAGFLKKIVGSKIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVFVDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQKFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVTMTHSSLLNASKIVKETLQLRNNSPLFSICSHTSGLGFMFSCLLGIYTGASTCLFSLTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSAKNNTSGSLREDVFKGVRNIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRSYLDIPPVDLYLDPFSLREGIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVDGEFGEIWCCSEANAFDYFVCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGEVVNLNLLFVLGSIHESIEILGLTHFVSDLERTVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSELLNKHGVILDLCTFVRTKGISPKNSSMIMEVWAKNRASIMQAWFDQKIQIEAQFGINYGENISIYLLSDYEKDNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25UbiquitinationNELIQDYKDENLTRK
HHHHHHHHCCCCCCC		67.8423749301
28N-linked_GlycosylationIQDYKDENLTRKGYE
HHHHHCCCCCCCCCH		57.77-
48PhosphorylationLLDKFEISQMRPYTP
HHHHHCHHHCCCCCC		15.6624961812
54PhosphorylationISQMRPYTPLRSPNS
HHHCCCCCCCCCCCC		20.6621440633
58PhosphorylationRPYTPLRSPNSRKSK
CCCCCCCCCCCCCCC		35.8028889911
61PhosphorylationTPLRSPNSRKSKHLH
CCCCCCCCCCCCHHH		44.4621551504
71N-linked_GlycosylationSKHLHRRNTSLASSI
CCHHHHCCCHHHHHH		33.70-
72PhosphorylationKHLHRRNTSLASSIT
CHHHHCCCHHHHHHH		24.2522369663
73PhosphorylationHLHRRNTSLASSITS
HHHHCCCHHHHHHHH		26.0322369663
76PhosphorylationRRNTSLASSITSLPN
HCCCHHHHHHHHCCC		27.8023749301
77PhosphorylationRNTSLASSITSLPNS
CCCHHHHHHHHCCCC		25.0322369663
79PhosphorylationTSLASSITSLPNSID
CHHHHHHHHCCCCHH		26.5922369663
80PhosphorylationSLASSITSLPNSIDR
HHHHHHHHCCCCHHC		39.9122369663
84PhosphorylationSITSLPNSIDRRHSI
HHHHCCCCHHCCCCE		24.7522369663
95PhosphorylationRHSIYRVTTINSTSA
CCCEEEEEEECCCCC		16.9828889911
96PhosphorylationHSIYRVTTINSTSAN
CCEEEEEEECCCCCC		18.4622369663
98N-linked_GlycosylationIYRVTTINSTSANNT
EEEEEEECCCCCCCC		36.82-
99PhosphorylationYRVTTINSTSANNTP
EEEEEECCCCCCCCC		21.6422369663
100PhosphorylationRVTTINSTSANNTPR
EEEEECCCCCCCCCC		27.6322369663
101PhosphorylationVTTINSTSANNTPRR
EEEECCCCCCCCCCC		28.9022369663
105PhosphorylationNSTSANNTPRRRSKR
CCCCCCCCCCCCCCC		20.2722369663
113PhosphorylationPRRRSKRYTASLQSS
CCCCCCCCEEHHHHC		15.4723749301
114PhosphorylationRRRSKRYTASLQSSL
CCCCCCCEEHHHHCC		17.5024961812
116PhosphorylationRSKRYTASLQSSLPG
CCCCCEEHHHHCCCC		21.1021440633
119PhosphorylationRYTASLQSSLPGSSD
CCEEHHHHCCCCCCC		38.8521440633
120PhosphorylationYTASLQSSLPGSSDE
CEEHHHHCCCCCCCC		26.1425521595
124PhosphorylationLQSSLPGSSDENGSV
HHHCCCCCCCCCCCH		32.4521440633
125PhosphorylationQSSLPGSSDENGSVK
HHCCCCCCCCCCCHH		55.6621440633
128N-linked_GlycosylationLPGSSDENGSVKDAV
CCCCCCCCCCHHHHH		53.69-
130PhosphorylationGSSDENGSVKDAVYN
CCCCCCCCHHHHHCC		37.2621440633
151N-linked_GlycosylationPRHTGAENTSSGDSA
CCCCCCCCCCCCCCC		44.73-
153PhosphorylationHTGAENTSSGDSAMT
CCCCCCCCCCCCCCC		43.8619779198
209N-linked_GlycosylationERVAHELNKSHLYKM
HHHHHHCCHHHHCEE		40.58-
254PhosphorylationPVSFETYSLREILEI
CCCCCCCCHHHHHHH		28.5027017623
288N-linked_GlycosylationDNLYSSSNHSKVKLV
HHHHCCCCCCCEEEE		45.45-
328N-linked_GlycosylationSPTFDIPNISYIEFT
CCCCCCCCCEEEEEE		35.85-
360PhosphorylationINQFETMTKILNSRS
ECHHHHHHHHHHCCC		23.5028889911
571PhosphorylationNEVECSITAMINSSS
CEEEEEEEEEECCCC		8.2230377154
575N-linked_GlycosylationCSITAMINSSSSFKD
EEEEEEECCCCCHHH		23.82-
576PhosphorylationSITAMINSSSSFKDY
EEEEEECCCCCHHHH		22.2230377154
577PhosphorylationITAMINSSSSFKDYL
EEEEECCCCCHHHHE		26.0523749301
578PhosphorylationTAMINSSSSFKDYLK
EEEECCCCCHHHHEE		39.3523749301
579PhosphorylationAMINSSSSFKDYLKL
EEECCCCCHHHHEEE		37.9623749301
583PhosphorylationSSSSFKDYLKLETFG
CCCCHHHHEEECCCC		13.3123749301
644N-linked_GlycosylationFVFKAKLNYSEMFSW
HHHEEECCHHHHHCC		37.26-
671PhosphorylationAVTEQLDTILNICPA
HHHHHHHHHHHHCCC		35.6427017623
680PhosphorylationLNICPANTYFMRTKL
HHHCCCCCCCHHHEE		21.9027017623
681PhosphorylationNICPANTYFMRTKLM
HHCCCCCCCHHHEEE		8.6627017623
730N-linked_GlycosylationLLYAKKGNQSAQPKG
CEEEECCCCCCCCCC		41.32-
743PhosphorylationKGNTGAESTKAIDIS
CCCCCCCCCEEEEHH		34.3727214570
750PhosphorylationSTKAIDISSLSGETS
CCEEEEHHHCCCCCC		22.8317563356
751PhosphorylationTKAIDISSLSGETSS
CEEEEHHHCCCCCCH		27.2117330950
753PhosphorylationAIDISSLSGETSSGY
EEEHHHCCCCCCHHH		36.2125521595
756PhosphorylationISSLSGETSSGYKRV
HHHCCCCCCHHHHHH		31.5529688323
760PhosphorylationSGETSSGYKRVVESH
CCCCCHHHHHHHHHH		9.5119779198
761UbiquitinationGETSSGYKRVVESHY
CCCCHHHHHHHHHHH		42.0924961812
779PhosphorylationITETVVRTVNTVFEV
HHHHHHHHHHHHHHH		13.3928889911
782PhosphorylationTVVRTVNTVFEVAAF
HHHHHHHHHHHHHHH		23.4128889911
820PhosphorylationEESKNGETTDTTLMK
HHHCCCCCCHHHHHH		31.2227017623
881N-linked_GlycosylationYCSLELANSTVEKKF
HHCCEECCCHHHHHH		51.33-
917N-linked_GlycosylationLPHSAYYNESILSEH
CCCHHHCCHHHHHHH		24.70-
995N-linked_GlycosylationWRISNYGNETAFSDG
HHHHHCCCCCCCCCC		32.84-
1009N-linked_GlycosylationGTNTNLVNSSASNDN
CCCCCCCCCCCCCCC		33.15-
1134AcetylationKYKSLIPKITVFSKV
HHHHHCCCEEEEECC		43.9724489116
1198N-linked_GlycosylationMTHSSLLNASKIVKE
ECHHHHHCHHHHHHH		47.68-
1301N-linked_GlycosylationENINSAKNNTSGSLR
HHHHHCCCCCCCCHH		57.64-
1302N-linked_GlycosylationNINSAKNNTSGSLRE
HHHHCCCCCCCCHHH		34.61-
1447N-linked_GlycosylationAFDYFVCNSSKNKLY
CCCEEEEECCCCCCC		43.97-
1472N-linked_GlycosylationSKMKSEVNNTLSYLR
HHHHHHHHHHHHHHH		31.55-
1488N-linked_GlycosylationGDLGFIKNVSCTNSQ
CCCCEEEEEEECCCC		26.56-
1565N-linked_GlycosylationRHNPILGNLTTLIVS
HCCCCCHHHHHHHHH		30.67-
1597N-linked_GlycosylationTKGISPKNSSMIMEV
CCCCCCCCCHHHHHH		42.58-
1634N-linked_GlycosylationFGINYGENISIYLLS
ECCCCCCCEEEEEEE		29.01-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YO093_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YO093_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YO093_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCOR_YEASTSPE1genetic
27708008
TRI1_YEASTTRI1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
CKS1_YEASTCKS1genetic
27708008
HAP3_YEASTHAP3genetic
27708008
BUD3_YEASTBUD3genetic
27708008
THRC_YEASTTHR4genetic
27708008
GMC1_YEASTGMC1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
RTG2_YEASTRTG2genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
RL34B_YEASTRPL34Bgenetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
YKY5_YEASTYKR005Cgenetic
27708008
GYS2_YEASTGSY2genetic
27708008
MMS22_YEASTMMS22genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
UBX2_YEASTUBX2genetic
27708008
NAB6_YEASTNAB6genetic
27708008
HFD1_YEASTHFD1genetic
27708008
GBLP_YEASTASC1genetic
27708008
RAD14_YEASTRAD14genetic
27708008
SKY1_YEASTSKY1genetic
27708008
PET8_YEASTPET8genetic
27708008
MKT1_YEASTMKT1genetic
27708008
CARME_YEASTYNL092Wgenetic
27708008
INO4_YEASTINO4genetic
27708008
RAD1_YEASTRAD1genetic
27708008
YP109_YEASTYPL109Cgenetic
27708008
AIM44_YEASTAIM44genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YO093_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-72; SER-73; SER-77;THR-105; SER-120 AND SER-751, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-751, AND MASSSPECTROMETRY.

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