MET5_YEAST - dbPTM
MET5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MET5_YEAST
UniProt AC P47169
Protein Name Sulfite reductase [NADPH] subunit beta
Gene Name MET5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1442
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate..
Protein Sequence MTASDLLTLPQLLAQYSSSAPQNKVFYTTSTKNSHSSFKGLESVATDATHLLNNQDPLNTIKDQLSKDILTTVFTDETTLVKSIHHLYSLPNKLPLVITVDLNLQDYSAIPALKDLSFPILISSDLQTAISNADSSYKIATSSLTPVFHFLNLEKIGTSTAIEQDIDFPTLEIANEETKVALSEATDSLTNFELVKGKESITTVIVNLSPYDAEFSSVLPSNVGLIKIRVYRPWNFSKFLEILPSSVTKIAVLQGVSKKSQSNEFQPFLLDFFGNFNELVSRNIEQVVLTNIGNVNDYGNVINTVISNINKKEPDNNLFLGESNEKAEEQAEVTQLISSVKKVVNLEDAYIKVLKQLFSSNLQILNQFSSETIEPSNPEFGFGRFLKQEAQREELISLAKTSLDPSLYLSEDANKIVQLLSKWLSFNGRDLDEAQLQEANATGLEIFQLLQSNQDSSTVLKFLKIAPTSDSFIFKSSWLIGSDAWSYDLGHSGIQQVLSSRKNINVLLIDSEPYDHRKQNQDRKKDVGLYAMNYYSAYVASVAVYASYTQLLTAIIEASKYNGPSIVLAYLPYNSENDTPLEVLKETKNAVESGYWPLYRFNPVYDDPSTDKEAFSLDSSVIRKQLQDFLDRENKLTLLTRKDPSLSRNLKQSAGDALTRKQEKRSKAAFDQLLEGLSGPPLHVYYASDGGNAANLAKRLAARASARGLKATVLSMDDIILEELPGEENVVFITSTAGQGEFPQDGKSFWEALKNDTDLDLASLNVAVFGLGDSEYWPRKEDKHYFNKPSQDLFKRLELLSAKALIPLGLGDDQDADGFQTAYSEWEPKLWEALGVSGAAVDDEPKPVTNEDIKRESNFLRGTISENLKDTSSGGVTHANEQLMKFHGIYTQDDRDIREIRKSQGLEPYYMFMARARLPGGKTTPQQWLALDHLSDTSGNGTLKLTTRATFQIHGVLKKNLKHTLRGMNAVLMDTLAAAGDVNRNVMVSALPTNAKVHQQIADMGKLISDHFLPKTTAYHEVWLEGPEEQDDDPSWPSIFENRKDGPRKKKTLVSGNALVDIEPIYGPTYLPRKFKFNIAVPPYNDVDVLSIDVGLVAIVNPETQIVEGYNVFVGGGMGTTHNNKKTYPRLGSCLGFVKTEDIIPPLEGIVIVQRDHGDRKDRKHARLKYTVDDMGVEGFKQKVEEYWGKKFEPERPFEFKSNIDYFGWIKDETGLNHFTAFIENGRVEDTPDLPQKTGIRKVAEYMLKTNSGHFRLTGNQHLVISNITDEHVAGIKSILKTYKLDNTDFSGLRLSSSSCVGLPTCGLAFAESERFLPDIITQLEDCLEEYGLRHDSIIMRMTGCPNGCSRPWLGELALVGKAPHTYNLMLGGGYLGQRLNKLYKANVKDEEIVDYIKPLFKRYALEREEGEHFGDFCIRVGIIKPTTEGKYFHEDVSEDAY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24UbiquitinationSSSAPQNKVFYTTST
CCCCCCCCEEEEECC		28.5917644757
67UbiquitinationTIKDQLSKDILTTVF
HHHHHHCCCHHHHHC		58.3317644757
82UbiquitinationTDETTLVKSIHHLYS
CCCHHHHHHHHHHHH		46.9717644757
138UbiquitinationSNADSSYKIATSSLT
HCCCCCCEEECCCCC		28.0117644757
155UbiquitinationFHFLNLEKIGTSTAI
EEECCHHHHCCCCCH		49.9917644757
238UbiquitinationYRPWNFSKFLEILPS
ECCCCHHHHHHHCCC		50.2417644757
246PhosphorylationFLEILPSSVTKIAVL
HHHHCCCCHHHHHHH		31.6928889911
258UbiquitinationAVLQGVSKKSQSNEF
HHHCCCCCCCCCCCC		54.7817644757
259UbiquitinationVLQGVSKKSQSNEFQ
HHCCCCCCCCCCCCH		46.3417644757
341UbiquitinationTQLISSVKKVVNLED
HHHHHHHHHHCCHHH		41.6217644757
342UbiquitinationQLISSVKKVVNLEDA
HHHHHHHHHCCHHHH		49.6217644757
352UbiquitinationNLEDAYIKVLKQLFS
CHHHHHHHHHHHHHH		28.9217644757
387UbiquitinationFGFGRFLKQEAQREE
CCHHHHHHHHHHHHH		43.3017644757
400UbiquitinationEELISLAKTSLDPSL
HHHHHHHHHCCCHHH		43.8917644757
415UbiquitinationYLSEDANKIVQLLSK
HCCCCHHHHHHHHHH		46.0717644757
475UbiquitinationTSDSFIFKSSWLIGS
CCCCEEEEECEECCC		38.4717644757
502UbiquitinationQQVLSSRKNINVLLI
HHHHHHCCCEEEEEE		65.2217644757
518UbiquitinationSEPYDHRKQNQDRKK
CCCCCCCCCCCHHHH		50.6217644757
561PhosphorylationAIIEASKYNGPSIVL
HHHHHHHCCCCEEEE		23.9028889911
565PhosphorylationASKYNGPSIVLAYLP
HHHCCCCEEEEEECC		27.0828889911
573PhosphorylationIVLAYLPYNSENDTP
EEEEECCCCCCCCCC		28.8228889911
579PhosphorylationPYNSENDTPLEVLKE
CCCCCCCCCHHHHHH		41.1628889911
588UbiquitinationLEVLKETKNAVESGY
HHHHHHHHHHHHHCC		43.9617644757
624UbiquitinationLDSSVIRKQLQDFLD
CCHHHHHHHHHHHHH		44.2117644757
635UbiquitinationDFLDRENKLTLLTRK
HHHHHCCCCHHHHCC		37.7917644757
635AcetylationDFLDRENKLTLLTRK
HHHHHCCCCHHHHCC		37.7925381059
667UbiquitinationRKQEKRSKAAFDQLL
HHHHHHHHHHHHHHH		48.0117644757
698UbiquitinationGNAANLAKRLAARAS
CCHHHHHHHHHHHHH		51.6217644757
747UbiquitinationGEFPQDGKSFWEALK
CCCCCCCHHHHHHHH		51.2517644757
754UbiquitinationKSFWEALKNDTDLDL
HHHHHHHHCCCCCCH		60.8817644757
780UbiquitinationDSEYWPRKEDKHYFN
CCCCCCCCCCCCCCC		67.2117644757
783UbiquitinationYWPRKEDKHYFNKPS
CCCCCCCCCCCCCCC		41.1017644757
788UbiquitinationEDKHYFNKPSQDLFK
CCCCCCCCCCHHHHH		35.8317644757
795UbiquitinationKPSQDLFKRLELLSA
CCCHHHHHHHHHHHH		64.4717644757
803UbiquitinationRLELLSAKALIPLGL
HHHHHHHHEEECCCC		40.1117644757
829UbiquitinationAYSEWEPKLWEALGV
HHHHCCHHHHHHHCC		55.5117644757
869UbiquitinationGTISENLKDTSSGGV
HHHCHHCCCCCCCCC		71.2217644757
885UbiquitinationHANEQLMKFHGIYTQ
CHHHHHHHHCCCCCC		42.6817644757
903PhosphorylationDIREIRKSQGLEPYY
HHHHHHHHCCCCCEE		21.4525752575
922UbiquitinationRARLPGGKTTPQQWL
EECCCCCCCCHHHHE		55.9617644757
944UbiquitinationTSGNGTLKLTTRATF
CCCCCEEEEEECEEE		43.5617644757
996UbiquitinationSALPTNAKVHQQIAD
EECCCCHHHHHHHHH		42.1717644757
1006UbiquitinationQQIADMGKLISDHFL
HHHHHHHHHHHHCCC		35.6917644757
1050UbiquitinationRKDGPRKKKTLVSGN
CCCCCCCCCEEEECC		52.8817644757
1051UbiquitinationKDGPRKKKTLVSGNA
CCCCCCCCEEEECCE		50.5617644757
1055PhosphorylationRKKKTLVSGNALVDI
CCCCEEEECCEEEEE		29.4628889911
1074UbiquitinationGPTYLPRKFKFNIAV
CCCCCCCCEEEEEEC		51.4717644757
1139UbiquitinationGSCLGFVKTEDIIPP
HHHCCEEEHHHCCCC		43.8917644757
1190UbiquitinationKVEEYWGKKFEPERP
HHHHHHCCCCCCCCC		39.8917644757
1191UbiquitinationVEEYWGKKFEPERPF
HHHHHCCCCCCCCCC		51.5317644757
1201UbiquitinationPERPFEFKSNIDYFG
CCCCCCCCCCCCEEE		35.0817644757
1252PhosphorylationEYMLKTNSGHFRLTG
HHHHHHCCCCEEECC		38.5927214570
1277UbiquitinationDEHVAGIKSILKTYK
HHHHHHHHHHHHHCC		30.4417644757
1281UbiquitinationAGIKSILKTYKLDNT
HHHHHHHHHCCCCCC		48.4117644757
1284UbiquitinationKSILKTYKLDNTDFS
HHHHHHCCCCCCCCC		55.3817644757
1291PhosphorylationKLDNTDFSGLRLSSS
CCCCCCCCCCEECCC		39.4627214570
1298PhosphorylationSGLRLSSSSCVGLPT
CCCEECCCCCCCCCC		25.1228889911
1299PhosphorylationGLRLSSSSCVGLPTC
CCEECCCCCCCCCCC		18.1228889911
1362UbiquitinationGELALVGKAPHTYNL
HHEEECCCCCCCEEE		51.7917644757
1385UbiquitinationQRLNKLYKANVKDEE
HHHHHHHHCCCCCHH		43.8717644757
1389UbiquitinationKLYKANVKDEEIVDY
HHHHCCCCCHHHHHH		60.2617644757
1398UbiquitinationEEIVDYIKPLFKRYA
HHHHHHHHHHHHHHC		29.4617644757
1402UbiquitinationDYIKPLFKRYALERE
HHHHHHHHHHCHHCC		52.7817644757
1425UbiquitinationCIRVGIIKPTTEGKY
EEEEEEECCCCCCCC		34.1017644757
1431UbiquitinationIKPTTEGKYFHEDVS
ECCCCCCCCCCCCCC		38.2117644757
1438PhosphorylationKYFHEDVSEDAY---
CCCCCCCCCCCC---		41.9228152593
1442PhosphorylationEDVSEDAY-------
CCCCCCCC-------		31.2628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MET5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MET5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MET5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP7F_YEASTSSE1physical
19536198
SSB1_YEASTSSB1physical
19536198
MET10_YEASTMET10genetic
16941010
SPEE_YEASTSPE3genetic
21623372
COX6_YEASTCOX6genetic
21623372
QCR9_YEASTQCR9genetic
21623372
METC_YEASTIRC7genetic
21623372
ADE_YEASTAAH1genetic
21623372
PDC6_YEASTPDC6genetic
21623372
PHO87_YEASTPHO87genetic
21623372
CDA1_YEASTCDA1genetic
21623372
NPT1_YEASTNPT1genetic
21623372
COQ7_YEASTCAT5genetic
21623372
OPT1_YEASTOPT1genetic
21623372
THI22_YEASTTHI22genetic
21623372
EPT1_YEASTEPT1genetic
21623372
ODPB_YEASTPDB1genetic
21623372
SDHX_YEASTYJL045Wgenetic
21623372
RIM15_YEASTRIM15genetic
27708008
CGR1_YEASTCGR1genetic
27708008
UBR2_YEASTUBR2genetic
27708008
MMR1_YEASTMMR1genetic
27708008
COA4_YEASTCOA4genetic
27708008
ADY4_YEASTADY4genetic
27708008
IZH2_YEASTIZH2genetic
27708008
BUD31_YEASTBUD31genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
RPA14_YEASTRPA14genetic
27708008
SAC3_YEASTSAC3genetic
27708008
HSP42_YEASTHSP42genetic
27708008
FIT1_YEASTFIT1genetic
27708008
SAK1_YEASTSAK1genetic
27708008
SA155_YEASTSAP155genetic
27708008
ERV14_YEASTERV14genetic
27708008
COM1_YEASTSAE2genetic
27708008
HOS2_YEASTHOS2genetic
27708008
ASK10_YEASTASK10genetic
27708008
AP3B_YEASTAPL6genetic
27708008
YOR1_YEASTYOR1genetic
27708008
SODM_YEASTSOD2genetic
27708008
POG1_YEASTPOG1genetic
27708008
ATG32_YEASTATG32genetic
27708008
VPS51_YEASTVPS51genetic
27708008
DBP7_YEASTDBP7genetic
27708008
SA190_YEASTSAP190genetic
27708008
BPT1_YEASTBPT1genetic
27708008
COX12_YEASTCOX12genetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
TOP3_YEASTTOP3genetic
27708008
EFM7_YEASTNNT1genetic
27708008
FKS1_YEASTFKS1genetic
27708008
ROM2_YEASTROM2genetic
27708008
CORO_YEASTCRN1genetic
27708008
SOK2_YEASTSOK2genetic
27708008
SIW14_YEASTSIW14genetic
27708008
OCA2_YEASTOCA2genetic
27708008
DGK1_YEASTDGK1genetic
27708008
FUMH_YEASTFUM1genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MET5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246; SER-1055; SER-1298;SER-1299; SER-1438 AND TYR-1442, AND MASS SPECTROMETRY.

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