| UniProt ID | SAK1_YEAST | |
|---|---|---|
| UniProt AC | P38990 | |
| Protein Name | SNF1-activating kinase 1 | |
| Gene Name | SAK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1142 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Serine/threonine-protein kinase that phosphorylates SNF1, the catalytic subunit of the SNF1 kinase complex. Acts as an activator of the SNF1 kinase complex and controls its nuclear localization upon glucose and nitrogen depletion. Also required for SNF1 kinase activation under other stress conditions like alkaline pH or presence of cadmium.. | |
| Protein Sequence | MDRSDKKVNVEEVNVPSNLQIELEKSGTSSSVSLRSPTKSSATNLAGMAEGARDNASIASSSVDSLNMLLERQRVRQLNHPQHQQHISSSLAKTPTTTSSFCSSGSSKNKVKETNRISLTYDPVSKRKVLNTYEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFVSWDFDHVPENDEKLLSSVLEQKLRFQCNQTDQFEPISISKHELKNAVSGVGKKIKESVLKSIPLKDPSDLSNKNYLHPTETTRGRGDANVIVSEGSVLSNIKELSANDGCLNTDSDTNININDDDHYSGDDNDGHLTKRELERELNKFDDKHEAGNMVNLPINSSFASLDSFYIDNFAMARMGMSSPEAGDSVSSVPNLPSAPSSTRLGRSPVFSGVTNQPSPIRPVLPQQKSSFCATGRYDKSHNSLLRNSSSHLTSYNSGRPSSRTGRMNSRNQNLPKIPNSLSKISTTKLTELRVPKDSEIPSPAKNPNADRLRRFPVKKNTKTPAIKDPPRININSSDKSGSKNSPIKSLYQRMKQSKDNSKTFEVRRGNFFSHFNGDDDDSSSQSSVTSSGSESDSELSSTSSSCTSGTQSRNSSNNNAYSETESLPFEFGVDSEDGSGVLLRDLPNEDQIRPFLDIQPCRRMKVKSSLNLEPPSVSSSSSSSSDEDELILNVGTAGHRRRHNSSKLSELSNSPQKGSNNFMYSNGSVHDSETTITPQNMDDLTLHQALSRSQPISKPGPLVLPKRLDQKKATTETSNLTDIVEFNGNNDHRKDKNFDKVLYSRDLLKDALSSTNAGRRRSIPSNKIRGRKDASITMSTNVGNDEHARNTSCHGDKGQENGAIKQRTHERSRSLTVAELNEEKRRSALP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | LQIELEKSGTSSSVS EEEEEEECCCCCEEE | 37.62 | 28889911 | |
| 29 | Phosphorylation | ELEKSGTSSSVSLRS EEEECCCCCEEEECC | 24.92 | 23749301 | |
| 30 | Phosphorylation | LEKSGTSSSVSLRSP EEECCCCCEEEECCC | 34.30 | 21551504 | |
| 31 | Phosphorylation | EKSGTSSSVSLRSPT EECCCCCEEEECCCC | 18.59 | 19779198 | |
| 33 | Phosphorylation | SGTSSSVSLRSPTKS CCCCCEEEECCCCCC | 21.73 | 21440633 | |
| 36 | Phosphorylation | SSSVSLRSPTKSSAT CCEEEECCCCCCCCH | 42.06 | 21440633 | |
| 38 | Phosphorylation | SVSLRSPTKSSATNL EEEECCCCCCCCHHH | 44.82 | 28889911 | |
| 40 | Phosphorylation | SLRSPTKSSATNLAG EECCCCCCCCHHHHH | 27.90 | 22369663 | |
| 41 | Phosphorylation | LRSPTKSSATNLAGM ECCCCCCCCHHHHHH | 40.44 | 22369663 | |
| 43 | Phosphorylation | SPTKSSATNLAGMAE CCCCCCCHHHHHHHC | 32.48 | 22890988 | |
| 60 | Phosphorylation | RDNASIASSSVDSLN CCCHHHHHCCHHHHH | 22.83 | 28889911 | |
| 61 | Phosphorylation | DNASIASSSVDSLNM CCHHHHHCCHHHHHH | 25.92 | 28889911 | |
| 62 | Phosphorylation | NASIASSSVDSLNML CHHHHHCCHHHHHHH | 27.70 | 27017623 | |
| 94 | Phosphorylation | ISSSLAKTPTTTSSF HHHHHCCCCCCCHHH | 21.91 | 25315811 | |
| 96 | Phosphorylation | SSLAKTPTTTSSFCS HHHCCCCCCCHHHCC | 48.19 | 28889911 | |
| 97 | Phosphorylation | SLAKTPTTTSSFCSS HHCCCCCCCHHHCCC | 26.36 | 28889911 | |
| 98 | Phosphorylation | LAKTPTTTSSFCSSG HCCCCCCCHHHCCCC | 25.50 | 21440633 | |
| 99 | Phosphorylation | AKTPTTTSSFCSSGS CCCCCCCHHHCCCCC | 21.23 | 22369663 | |
| 100 | Phosphorylation | KTPTTTSSFCSSGSS CCCCCCHHHCCCCCC | 28.34 | 22369663 | |
| 103 | Phosphorylation | TTTSSFCSSGSSKNK CCCHHHCCCCCCCCC | 35.41 | 22369663 | |
| 104 | Phosphorylation | TTSSFCSSGSSKNKV CCHHHCCCCCCCCCC | 43.82 | 22369663 | |
| 106 | Phosphorylation | SSFCSSGSSKNKVKE HHHCCCCCCCCCCEE | 39.84 | 22369663 | |
| 107 | Phosphorylation | SFCSSGSSKNKVKET HHCCCCCCCCCCEEC | 43.72 | 22369663 | |
| 121 | Phosphorylation | TNRISLTYDPVSKRK CCCCEEEECCCCCHH | 24.44 | 27017623 | |
| 137 | Acetylation | LNTYEIIKELGHGQH EHHHHHHHHHCCCCC | 53.18 | 24489116 | |
| 181 | Phosphorylation | FFTFIKSSKISENDK HHHHHHCCCCCCCHH | 29.07 | 21551504 | |
| 310 | Phosphorylation | SSTNSSDSSESLDEL ECCCCCCCCCCHHHH | 37.64 | 27214570 | |
| 313 | Phosphorylation | NSSDSSESLDELELA CCCCCCCCHHHHHHH | 42.97 | 27214570 | |
| 541 | Phosphorylation | GDANVIVSEGSVLSN CCCEEEECCCCHHHC | 25.72 | 22369663 | |
| 544 | Phosphorylation | NVIVSEGSVLSNIKE EEEECCCCHHHCHHH | 18.81 | 22369663 | |
| 547 | Phosphorylation | VSEGSVLSNIKELSA ECCCCHHHCHHHHHC | 34.06 | 22369663 | |
| 563 | Phosphorylation | DGCLNTDSDTNININ CCCCCCCCCCCCCCC | 44.27 | 19779198 | |
| 565 | Phosphorylation | CLNTDSDTNININDD CCCCCCCCCCCCCCC | 41.78 | 21440633 | |
| 575 | Phosphorylation | NINDDDHYSGDDNDG CCCCCCCCCCCCCCC | 22.73 | 20377248 | |
| 585 | Phosphorylation | DDNDGHLTKRELERE CCCCCCCCHHHHHHH | 23.52 | 20377248 | |
| 633 | Phosphorylation | AMARMGMSSPEAGDS HHHHCCCCCCCCCCC | 36.69 | 19779198 | |
| 634 | Phosphorylation | MARMGMSSPEAGDSV HHHCCCCCCCCCCCC | 20.19 | 19779198 | |
| 640 | Phosphorylation | SSPEAGDSVSSVPNL CCCCCCCCCCCCCCC | 23.99 | 27017623 | |
| 642 | Phosphorylation | PEAGDSVSSVPNLPS CCCCCCCCCCCCCCC | 29.57 | 19779198 | |
| 649 | Phosphorylation | SSVPNLPSAPSSTRL CCCCCCCCCCCCCCC | 56.85 | 19779198 | |
| 652 | Phosphorylation | PNLPSAPSSTRLGRS CCCCCCCCCCCCCCC | 44.02 | 23749301 | |
| 653 | Phosphorylation | NLPSAPSSTRLGRSP CCCCCCCCCCCCCCC | 19.25 | 27017623 | |
| 654 | Phosphorylation | LPSAPSSTRLGRSPV CCCCCCCCCCCCCCC | 33.96 | 21440633 | |
| 659 | Phosphorylation | SSTRLGRSPVFSGVT CCCCCCCCCCCCCCC | 24.50 | 23749301 | |
| 670 | Phosphorylation | SGVTNQPSPIRPVLP CCCCCCCCCCCCCCC | 24.16 | 21440633 | |
| 681 | Phosphorylation | PVLPQQKSSFCATGR CCCCCCCCCCCCCCC | 25.06 | 30377154 | |
| 682 | Phosphorylation | VLPQQKSSFCATGRY CCCCCCCCCCCCCCC | 31.23 | 23749301 | |
| 692 | Phosphorylation | ATGRYDKSHNSLLRN CCCCCCCCCCHHCCC | 25.63 | 28889911 | |
| 700 | Phosphorylation | HNSLLRNSSSHLTSY CCHHCCCCCCCCCCC | 27.12 | 28889911 | |
| 701 | Phosphorylation | NSLLRNSSSHLTSYN CHHCCCCCCCCCCCC | 25.89 | 30377154 | |
| 732 | Phosphorylation | NLPKIPNSLSKISTT CCCCCCCCHHHCCCC | 28.76 | 21440633 | |
| 734 | Phosphorylation | PKIPNSLSKISTTKL CCCCCCHHHCCCCCC | 27.97 | 21440633 | |
| 737 | Phosphorylation | PNSLSKISTTKLTEL CCCHHHCCCCCCCEE | 33.49 | 20377248 | |
| 738 | Phosphorylation | NSLSKISTTKLTELR CCHHHCCCCCCCEEC | 31.27 | 20377248 | |
| 739 | Phosphorylation | SLSKISTTKLTELRV CHHHCCCCCCCEECC | 19.78 | 21440633 | |
| 742 | Phosphorylation | KISTTKLTELRVPKD HCCCCCCCEECCCCC | 34.23 | 24961812 | |
| 754 | Phosphorylation | PKDSEIPSPAKNPNA CCCCCCCCCCCCCCH | 43.05 | 21440633 | |
| 813 | Phosphorylation | MKQSKDNSKTFEVRR HHHCCCCCCCEEEEC | 43.11 | 23749301 | |
| 815 | Phosphorylation | QSKDNSKTFEVRRGN HCCCCCCCEEEECCC | 25.50 | 27214570 | |
| 867 | Phosphorylation | SGTQSRNSSNNNAYS CCCCCCCCCCCCCCC | 33.08 | 28889911 | |
| 868 | Phosphorylation | GTQSRNSSNNNAYSE CCCCCCCCCCCCCCC | 47.31 | 28889911 | |
| 961 | Phosphorylation | RHNSSKLSELSNSPQ HCCCCHHHHHCCCCC | 39.98 | 29136822 | |
| 964 | Phosphorylation | SSKLSELSNSPQKGS CCHHHHHCCCCCCCC | 31.07 | 22369663 | |
| 966 | Phosphorylation | KLSELSNSPQKGSNN HHHHHCCCCCCCCCC | 25.90 | 22369663 | |
| 980 | Phosphorylation | NFMYSNGSVHDSETT CCCCCCCCCCCCCCC | 22.11 | 21440633 | |
| 1005 | Phosphorylation | LHQALSRSQPISKPG HHHHHHCCCCCCCCC | 36.61 | 23749301 | |
| 1056 | Phosphorylation | NFDKVLYSRDLLKDA CHHHHHHCHHHHHHH | 18.37 | 21440633 | |
| 1065 | Phosphorylation | DLLKDALSSTNAGRR HHHHHHHHCCCCCCC | 36.52 | 19823750 | |
| 1066 | Phosphorylation | LLKDALSSTNAGRRR HHHHHHHCCCCCCCC | 26.91 | 24961812 | |
| 1067 | Phosphorylation | LKDALSSTNAGRRRS HHHHHHCCCCCCCCC | 26.22 | 21440633 | |
| 1074 | Phosphorylation | TNAGRRRSIPSNKIR CCCCCCCCCCCCCCC | 36.72 | 21440633 | |
| 1077 | Phosphorylation | GRRRSIPSNKIRGRK CCCCCCCCCCCCCCC | 49.43 | 24961812 | |
| 1087 | Phosphorylation | IRGRKDASITMSTNV CCCCCCCEEEEEECC | 28.82 | 30377154 | |
| 1092 | Phosphorylation | DASITMSTNVGNDEH CCEEEEEECCCCCHH | 24.09 | 30377154 | |
| 1103 | Phosphorylation | NDEHARNTSCHGDKG CCHHHCCCCCCCCCC | 27.46 | 21440633 | |
| 1104 | Phosphorylation | DEHARNTSCHGDKGQ CHHHCCCCCCCCCCC | 13.99 | 20377248 | |
| 1120 | Phosphorylation | NGAIKQRTHERSRSL CCCCCHHHHHHHCCC | 26.12 | 19823750 | |
| 1124 | Phosphorylation | KQRTHERSRSLTVAE CHHHHHHHCCCCHHH | 24.20 | 22369663 | |
| 1126 | Phosphorylation | RTHERSRSLTVAELN HHHHHHCCCCHHHHC | 29.64 | 22369663 | |
| 1128 | Phosphorylation | HERSRSLTVAELNEE HHHHCCCCHHHHCHH | 20.93 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SAK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SAK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SAK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-38; SER-40; SER-41;SER-99; SER-964; SER-1124; SER-1126 AND THR-1128, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-41; SER-1126 ANDTHR-1128, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1126, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1126, AND MASSSPECTROMETRY. | |
