KPR2_YEAST - dbPTM
KPR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KPR2_YEAST
UniProt AC P38620
Protein Name Ribose-phosphate pyrophosphokinase 2
Gene Name PRS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 318
Subcellular Localization Cytoplasm .
Protein Description 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)..
Protein Sequence MSTNSIKLLAGNSHPGLAELISQRLGVPLSKVGVYQYSNKETSVTIGESIRDEDVYIIQTGYGEHEINDFLMELLILIHACKTASVRRITAVIPNFPYARQDKKDKSRAPITAKLIANLLETAGCDHVITMDLHASQIQGFFHIPVDNLYGEPSVLNYIRTKTDFNNAILVSPDAGGAKRVASLADKLDMNFALIHKERQKANEVSRMLLVGDVAGKSCLLIDDMADTCGTLVKACDTLMDHGAKEVIAIVTHGIFSGSAREKLINSRLSRIVCTNTVPVDLDLDIVDQVDISPTIAEAIRRLHNGESVSYLFTHAPV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
218PhosphorylationVGDVAGKSCLLIDDM
HCCCCCCEEEEEHHH		14.7419779198
228PhosphorylationLIDDMADTCGTLVKA
EEHHHHHHHHHHHHH		11.8719779198
231PhosphorylationDMADTCGTLVKACDT
HHHHHHHHHHHHHHH		30.4427017623
238PhosphorylationTLVKACDTLMDHGAK
HHHHHHHHHHHCCHH		24.7019779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KPR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KPR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KPR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KPR4_YEASTPRS4genetic
10212224
KPR1_YEASTPRS1physical
11283351
KPR5_YEASTPRS5physical
11283351
KPR2_YEASTPRS2physical
18467557
KPR1_YEASTPRS1physical
18467557
KPR4_YEASTPRS4genetic
18408719
ADK_YEASTADO1genetic
21623372
6PGD1_YEASTGND1genetic
21623372
ERD2_YEASTERD2genetic
27708008
CND2_YEASTBRN1genetic
27708008
ACT_YEASTACT1genetic
27708008
ARP4_YEASTARP4genetic
27708008
TIM14_YEASTPAM18genetic
27708008
SMC4_YEASTSMC4genetic
27708008
CAP_YEASTSRV2genetic
27708008
OST2_YEASTOST2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
CHK1_YEASTCHK1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
THI3_YEASTTHI3genetic
27708008
RPA14_YEASTRPA14genetic
27708008
RAD14_YEASTRAD14genetic
27708008
PET8_YEASTPET8genetic
27708008
EOS1_YEASTEOS1genetic
27708008
IZH2_YEASTIZH2genetic
27708008
HAP5_YEASTHAP5genetic
27708008
CDC15_YEASTCDC15genetic
27708008
MED8_YEASTMED8genetic
27708008
TAF5_YEASTTAF5genetic
27708008
KRR1_YEASTKRR1genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RPB1_YEASTRPO21genetic
27708008
TFB1_YEASTTFB1genetic
27708008
GPI8_YEASTGPI8genetic
27708008
TFC4_YEASTTFC4genetic
27708008
SMD1_YEASTSMD1genetic
27708008
SYMC_YEASTMES1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
ORC6_YEASTORC6genetic
27708008
NOP56_YEASTNOP56genetic
27708008
MCM5_YEASTMCM5genetic
27708008
GSP1_YEASTGSP1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
GRPE_YEASTMGE1genetic
27708008
DYR_YEASTDFR1genetic
27708008
RCR1_YEASTRCR1genetic
27708008
CSG2_YEASTCSG2genetic
27708008
IMG2_YEASTIMG2genetic
27708008
FUB1_YEASTFUB1genetic
27708008
CSM1_YEASTCSM1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
PBP4_YEASTPBP4genetic
27708008
NRP1_YEASTNRP1genetic
27708008
WWM1_YEASTWWM1genetic
27708008
IES1_YEASTIES1genetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
PHB2_YEASTPHB2genetic
27708008
SSF1_YEASTSSF1genetic
27708008
MPH1_YEASTMPH1genetic
27708008
CBF1_YEASTCBF1genetic
27708008
FRA1_YEASTFRA1genetic
27708008
SAM37_YEASTSAM37genetic
27708008
YM01_YEASTYMR111Cgenetic
27708008
DIA1_YEASTDIA1genetic
27708008
MDM38_YEASTMDM38genetic
27708008
CHL1_YEASTCHL1genetic
27708008
NACB1_YEASTEGD1genetic
27708008
NIP80_YEASTNIP100genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KPR2_YEAST

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Related Literatures of Post-Translational Modification

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