| UniProt ID | TOS3_YEAST | |
|---|---|---|
| UniProt AC | P43637 | |
| Protein Name | Serine/threonine-protein kinase TOS3 | |
| Gene Name | TOS3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 560 | |
| Subcellular Localization | ||
| Protein Description | One of the three SNF1 protein kinases (with SAK1 and ELM1) which are required for growth on nonfermentable carbon sources and nonpreferred sugars and for response to environmental stress. Activates SNF1 by phosphorylation of its activation-loop 'Thr-210'. Required for the regulation by SNF1 of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes. Phosphorylates also GAL83, MIG1 and SIP2.. | |
| Protein Sequence | MVLLKEPVQPLPRSSLLYNNASNSSSRIKETRKVKLLYNPLTKRQILNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFMCHYGKSDAASVLTNLETFHELKVSPPSSCKRVELVSLPVNSSFASLDSVYMENFDHNNLRTGADRNSTYSPSIYDANTLSPSAYHNIGSRESSYSSFSSFTSSTAFASQISIQDAPAIGDQQCLIGESGSSLRVNSCEFPQYTTMSPVGEYPFESTEASLSSTLTPVGNVPQRIKAHLVEGKSNSKDDLRIEADASLVFEASDAQRTRRRMSLYKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | Phosphorylation | KLLYNPLTKRQILNN CEECCCCCHHHHHHC | 25.99 | 28889911 | |
| 55 | Phosphorylation | NNFEILATLGNGQYG HCCEEEEECCCCCCC | 31.58 | 28889911 | |
| 61 | Phosphorylation | ATLGNGQYGKVKLAR EECCCCCCCEEEEEE | 21.95 | 28889911 | |
| 231 | Phosphorylation | SHEQLLKSRALGTPA HHHHHHHHHHHCCCC | 23.82 | 20377248 | |
| 236 | Phosphorylation | LKSRALGTPAFFAPE HHHHHHCCCCHHCHH | 16.58 | 27214570 | |
| 386 | Phosphorylation | VSLPVNSSFASLDSV EEECCCCCCCCCCEE | 21.45 | 28889911 | |
| 413 | Phosphorylation | GADRNSTYSPSIYDA CCCCCCCCCCCCCCC | 20.57 | 23749301 | |
| 414 | Phosphorylation | ADRNSTYSPSIYDAN CCCCCCCCCCCCCCC | 16.56 | 23749301 | |
| 424 | Phosphorylation | IYDANTLSPSAYHNI CCCCCCCCHHHHCCC | 18.12 | 23749301 | |
| 487 | Phosphorylation | SCEFPQYTTMSPVGE ECCCCCCEEECCCCC | 15.69 | 28889911 | |
| 509 | Phosphorylation | ASLSSTLTPVGNVPQ CCCCCCCCCCCCCCH | 18.93 | 27214570 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TOS3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TOS3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TOS3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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