MET2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET2_YEAST
• UniProt AC: P08465
• Protein Name: Homoserine O-acetyltransferase
• Gene Name: MET2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 486
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTNCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MSHTLKSKTLQEL --CCCCCCCCCCCCC	51.57	17644757
8	Ubiquitination	MSHTLKSKTLQELDI CCCCCCCCCCCCCCH	52.22	17644757
19	Ubiquitination	ELDIEEIKETNPLLK CCCHHHHHHHCCHHH	62.86	17644757
26	Ubiquitination	KETNPLLKLVQGQRI HHHCCHHHHHCCCEE	55.05	17644757
55	Ubiquitination	NNFPIAYKTWGTLNE ECCCCEEEEEECCCH	28.87	17644757
153	Ubiquitination	VLDSLGVKSIACVIG HHHHCCCCEEEEEEC	34.05	17644757
181	Ubiquitination	MYGKEYVKNMVALAT HHCHHHHHHHHHHHH	38.12	17644757
250	Phosphorylation	NSFENKFSRRSPSIA CCCCCCCCCCCHHHH	28.52	29136822
253	Phosphorylation	ENKFSRRSPSIAQQQ CCCCCCCCHHHHHHH	23.14	29136822
255	Phosphorylation	KFSRRSPSIAQQQKA CCCCCCHHHHHHHHH	31.63	25704821
267	Phosphorylation	QKAQREETRKPSTVS HHHHHHHHCCCCCCC	38.96	19779198
269	Ubiquitination	AQREETRKPSTVSEH HHHHHHCCCCCCCHH	51.22	17644757
271	Phosphorylation	REETRKPSTVSEHSL HHHHCCCCCCCHHHE	44.47	30377154
272	Phosphorylation	EETRKPSTVSEHSLQ HHHCCCCCCCHHHEE	36.26	28889911
274	Phosphorylation	TRKPSTVSEHSLQIH HCCCCCCCHHHEEEC	29.67	28889911
286	Ubiquitination	QIHNDGYKTKASTAI EECCCCCCCEECEEE	49.42	17644757
311	Phosphorylation	VVSTASSSDSLNSST EEEECCCCCCCCCCC	28.82	19779198
316	Phosphorylation	SSSDSLNSSTSMTSV CCCCCCCCCCCCEEE	40.04	19779198
318	Phosphorylation	SDSLNSSTSMTSVSS CCCCCCCCCCEEEEH	23.49	19779198
352	Acetylation	YLRYQGTKFINRFDA HHHCCCCCEECCCCC	51.58	22865919
368	Ubiquitination	CYIAITRKLDTHDLA EEEEEEECCCHHHHH	41.90	17644757
473	Ubiquitination	DVGNDETKTSVFGEA CCCCCCCCCCCCCCH	36.43	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MET2_YEAST	MET2	physical	18719252
IPYR_YEAST	IPP1	genetic	27708008
CDK1_YEAST	CDC28	genetic	27708008
MCM7_YEAST	MCM7	genetic	27708008
NOT1_YEAST	CDC39	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
PANK_YEAST	CAB1	genetic	27708008
PSB3_YEAST	PUP3	genetic	27708008
RPN11_YEAST	RPN11	genetic	27708008
CDC14_YEAST	CDC14	genetic	27708008
YIP1_YEAST	YIP1	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
MOB1_YEAST	MOB1	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
STS1_YEAST	STS1	genetic	27708008
NU192_YEAST	NUP192	genetic	27708008
GWT1_YEAST	GWT1	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
ATG5_YEAST	ATG5	genetic	24785424

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.