IDS2_YEAST - dbPTM
IDS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IDS2_YEAST
UniProt AC P46958
Protein Name IME2-dependent-signaling protein
Gene Name IDS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 469
Subcellular Localization
Protein Description Seems to act indirectly to modify IME2 activity, thus permitting IME2 to carry out later meiotic functions..
Protein Sequence MDNQQESISEDITGDLAAAVRKSWSESQDNPLLLNFNNSPIGTPTDRYSPEPATMMEGNAMNLSSLARGSTQQQQRLYGSSQTREKSDQQQQDYQLFKHHYSLGQETRESVSDILNDLTLGSPEPSERASPIRQPSVDVPPLTTRRSSIQDVQWIRHLLNPRSSFSGASSNEPTNSPGDFLNQSRAWITILHDSSAESLQAVIVLAESLKNVNSQYNLWVLHSSEVNAFQLAQVGIKTLIIDEYINLFMNFGTGSGFSASSQSTETKGELNFKWCKLFLFFSLIDRFELICYLSPTCLVLQNIDELLESTEVSDEIDNETCVLLSNKVNYINEDLVSVNQDQSSAENYDDDPQIIILKPNRAVAMCIKEYFTIYGNDFEGESKRSMFHQMNDLQIMKALFGDKWSYIDSVGYCAVPIASVPANRLNYKIIEFKILKPWERQNYIAAGQHRESIMNKWLDLWRDFLNQAN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDNQQESI
-------CCCHHHHH		11.1622814378
7Phosphorylation-MDNQQESISEDITG
-CCCHHHHHHHCHHH		27.3830377154
13PhosphorylationESISEDITGDLAAAV
HHHHHCHHHHHHHHH		36.6428889911
23PhosphorylationLAAAVRKSWSESQDN
HHHHHHHHCCCCCCC		25.8528889911
25PhosphorylationAAVRKSWSESQDNPL
HHHHHHCCCCCCCCE		34.1719779198
27PhosphorylationVRKSWSESQDNPLLL
HHHHCCCCCCCCEEE		37.0023749301
39PhosphorylationLLLNFNNSPIGTPTD
EEEECCCCCCCCCCC		20.9923749301
43PhosphorylationFNNSPIGTPTDRYSP
CCCCCCCCCCCCCCC		24.6028889911
45PhosphorylationNSPIGTPTDRYSPEP
CCCCCCCCCCCCCCC		32.7126447709
48PhosphorylationIGTPTDRYSPEPATM
CCCCCCCCCCCCCCC		31.2427017623
49PhosphorylationGTPTDRYSPEPATMM
CCCCCCCCCCCCCCC		24.5527017623
64PhosphorylationEGNAMNLSSLARGST
CCCCCCHHHHHCCCH		20.5028889911
65PhosphorylationGNAMNLSSLARGSTQ
CCCCCHHHHHCCCHH		29.2528889911
81PhosphorylationQQRLYGSSQTREKSD
HHHHHCCCCCCCCCH		31.0727214570
87PhosphorylationSSQTREKSDQQQQDY
CCCCCCCCHHHHHHH		35.5827017623
94PhosphorylationSDQQQQDYQLFKHHY
CHHHHHHHHHHHHHH		11.6327017623
110PhosphorylationLGQETRESVSDILND
CCHHHHHHHHHHHHH		24.5122369663
112PhosphorylationQETRESVSDILNDLT
HHHHHHHHHHHHHCC		28.3622369663
119PhosphorylationSDILNDLTLGSPEPS
HHHHHHCCCCCCCHH		31.7522369663
122PhosphorylationLNDLTLGSPEPSERA
HHHCCCCCCCHHHCC		29.2422369663
126PhosphorylationTLGSPEPSERASPIR
CCCCCCHHHCCCCCC		37.7419779198
130PhosphorylationPEPSERASPIRQPSV
CCHHHCCCCCCCCCC		27.3815665377
136PhosphorylationASPIRQPSVDVPPLT
CCCCCCCCCCCCCCC		23.7021082442
144PhosphorylationVDVPPLTTRRSSIQD
CCCCCCCCCCCHHHH		31.5919779198
147PhosphorylationPPLTTRRSSIQDVQW
CCCCCCCCHHHHHHH		28.6222369663
148PhosphorylationPLTTRRSSIQDVQWI
CCCCCCCHHHHHHHH		23.5822369663
163PhosphorylationRHLLNPRSSFSGASS
HHHHCCCCCCCCCCC		36.6722369663
164PhosphorylationHLLNPRSSFSGASSN
HHHCCCCCCCCCCCC		25.3922369663
166PhosphorylationLNPRSSFSGASSNEP
HCCCCCCCCCCCCCC		35.0822369663
169PhosphorylationRSSFSGASSNEPTNS
CCCCCCCCCCCCCCC		36.9022369663
170PhosphorylationSSFSGASSNEPTNSP
CCCCCCCCCCCCCCC		44.6822369663
174PhosphorylationGASSNEPTNSPGDFL
CCCCCCCCCCCCHHH		41.9922369663
176PhosphorylationSSNEPTNSPGDFLNQ
CCCCCCCCCCHHHHH		32.5129136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IDS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IDS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IDS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CARP_YEASTPEP4physical
16554755
CARP_YEASTPEP4physical
16429126
PSB6_YEASTPRE7genetic
27708008
TSC3_YEASTTSC3genetic
27708008
ORC2_YEASTORC2genetic
27708008
TECR_YEASTTSC13genetic
27708008
LCB2_YEASTLCB2genetic
27708008
RRP45_YEASTRRP45genetic
27708008
NSE3_YEASTNSE3genetic
27708008
SRPR_YEASTSRP101genetic
27708008
GPI8_YEASTGPI8genetic
27708008
ACT_YEASTACT1genetic
27708008
PMM_YEASTSEC53genetic
27708008
PSB7_YEASTPRE4genetic
27708008
YIP1_YEASTYIP1genetic
27708008
MET30_YEASTMET30genetic
27708008
SPC3_YEASTSPC3genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SC61A_YEASTSEC61genetic
27708008
LCB1_YEASTLCB1genetic
27708008
SYA_YEASTALA1genetic
27708008
TIM50_YEASTTIM50genetic
27708008
MED10_YEASTNUT2genetic
27708008
KPYK1_YEASTCDC19genetic
27708008
MCM2_YEASTMCM2genetic
27708008
LSM2_YEASTLSM2genetic
27708008
CND2_YEASTBRN1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
CDS1_YEASTCDS1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
AME1_YEASTAME1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
CDC7_YEASTCDC7genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
TCPD_YEASTCCT4genetic
27708008
YRB1_YEASTYRB1genetic
27708008
TPIS_YEASTTPI1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
UTP5_YEASTUTP5genetic
27708008
RMRP_YEASTSNM1genetic
27708008
SEC4_YEASTSEC4genetic
27708008
CAK1_YEASTCAK1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
CDC20_YEASTCDC20genetic
27708008
GPI10_YEASTGPI10genetic
27708008
DBF2_YEASTDBF2genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
SYYC_YEASTTYS1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
BCD1_YEASTBCD1genetic
27708008
DNA2_YEASTDNA2genetic
27708008
CENPA_YEASTCSE4genetic
27708008
ASK1_YEASTASK1genetic
27708008
ABF1_YEASTABF1genetic
27708008
HYM1_YEASTHYM1genetic
27708008
PRP19_YEASTPRP19genetic
27708008
NSE1_YEASTNSE1genetic
27708008
GAA1_YEASTGAA1genetic
27708008
BBP_YEASTMSL5genetic
27708008
RU1C_YEASTYHC1genetic
27708008
CDC25_YEASTCDC25genetic
27708008
IMB1_YEASTKAP95genetic
27708008
AFG2_YEASTAFG2genetic
27708008
RNA14_YEASTRNA14genetic
27708008
SEC14_YEASTSEC14genetic
27708008
PRP24_YEASTPRP24genetic
27708008
DPOA_YEASTPOL1genetic
27708008
NAT10_YEASTKRE33genetic
27708008
RPC6_YEASTRPC34genetic
27708008
TYSY_YEASTCDC21genetic
27708008
RPC1_YEASTRPO31genetic
27708008
SMP3_YEASTSMP3genetic
27708008
ESA1_YEASTESA1genetic
27708008
CET1_YEASTCET1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ORC4_YEASTORC4genetic
27708008
PRP4_YEASTPRP4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IDS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-13; SER-23; SER-39;SER-122; SER-130; SER-136; SER-147; SER-148; SER-163; SER-166 ANDSER-169, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-163, ANDMASS SPECTROMETRY.

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