| UniProt ID | SEC14_YEAST | |
|---|---|---|
| UniProt AC | P24280 | |
| Protein Name | SEC14 cytosolic factor | |
| Gene Name | SEC14 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 304 | |
| Subcellular Localization |
Golgi apparatus membrane Peripheral membrane protein. |
|
| Protein Description | Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.. | |
| Protein Sequence | MVTQQEKEFLESYPQNCPPDALPGTPGNLDSAQEKALAELRKLLEDAGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKWRKDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEERMLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAYSVMSYVREASYISQNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLPVKFGGKSEVDESKGGLYLSDIGPWRDPKYIGPEGEAPEAFSMK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Ubiquitination | -MVTQQEKEFLESYP -CCCHHHHHHHHHCC | 49.80 | 23749301 | |
| 12 | Phosphorylation | QEKEFLESYPQNCPP HHHHHHHHCCCCCCC | 44.23 | 28132839 | |
| 42 | Ubiquitination | KALAELRKLLEDAGF HHHHHHHHHHHHCCH | 70.78 | 23749301 | |
| 66 | Acetylation | LRFLRARKFDVQLAK HHHHHHHCCCHHHHH | 44.95 | 22865919 | |
| 81 | Ubiquitination | EMFENCEKWRKDYGT HHHHHHHHHHHHHCC | 55.27 | 22817900 | |
| 84 | Ubiquitination | ENCEKWRKDYGTDTI HHHHHHHHHHCCCCH | 54.94 | 23749301 | |
| 88 | Phosphorylation | KWRKDYGTDTILQDF HHHHHHCCCCHHHHC | 24.60 | 22369663 | |
| 90 | Phosphorylation | RKDYGTDTILQDFHY HHHHCCCCHHHHCCC | 24.35 | 22369663 | |
| 100 | Acetylation | QDFHYDEKPLIAKFY HHCCCCCCCCHHHHC | 42.07 | 24489116 | |
| 105 | Acetylation | DEKPLIAKFYPQYYH CCCCCHHHHCHHHCC | 38.14 | 24489116 | |
| 116 | Acetylation | QYYHKTDKDGRPVYF HHCCCCCCCCCEEEH | 68.28 | 24489116 | |
| 136 | Acetylation | VNLHEMNKVTSEERM CCHHHHCCCCCHHHH | 45.65 | 24489116 | |
| 139 | Phosphorylation | HEMNKVTSEERMLKN HHHCCCCCHHHHHHH | 40.21 | 21440633 | |
| 145 | Ubiquitination | TSEERMLKNLVWEYE CCHHHHHHHHHHHHH | 38.60 | 23749301 | |
| 229 | Acetylation | STAFRLFKPFLDPVT CHHHHHHHCCCCCEE | 39.18 | 24489116 | |
| 236 | Phosphorylation | KPFLDPVTVSKIFIL HCCCCCEEEEEEEEE | 25.17 | 19823750 | |
| 238 | Phosphorylation | FLDPVTVSKIFILGS CCCCEEEEEEEEECH | 15.63 | 19795423 | |
| 245 | Phosphorylation | SKIFILGSSYQKELL EEEEEECHHHHHHHH | 23.56 | 22369663 | |
| 246 | Phosphorylation | KIFILGSSYQKELLK EEEEECHHHHHHHHH | 29.77 | 22369663 | |
| 247 | Phosphorylation | IFILGSSYQKELLKQ EEEECHHHHHHHHHC | 25.87 | 22369663 | |
| 249 | Ubiquitination | ILGSSYQKELLKQIP EECHHHHHHHHHCCC | 41.94 | 24961812 | |
| 249 | Acetylation | ILGSSYQKELLKQIP EECHHHHHHHHHCCC | 41.94 | 24489116 | |
| 253 | Acetylation | SYQKELLKQIPAENL HHHHHHHHCCCHHHC | 59.82 | 24489116 | |
| 263 | Acetylation | PAENLPVKFGGKSEV CHHHCCCEECCCCCC | 36.03 | 24489116 | |
| 267 | Acetylation | LPVKFGGKSEVDESK CCCEECCCCCCCCCC | 43.77 | 22865919 | |
| 274 | Acetylation | KSEVDESKGGLYLSD CCCCCCCCCCEEECC | 55.75 | 24489116 | |
| 280 | Phosphorylation | SKGGLYLSDIGPWRD CCCCEEECCCCCCCC | 17.39 | 21440633 | |
| 289 | Acetylation | IGPWRDPKYIGPEGE CCCCCCCCCCCCCCC | 54.51 | 24489116 | |
| 302 | Phosphorylation | GEAPEAFSMK----- CCCCCHHCCC----- | 32.48 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEC14_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEC14_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEC14_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302, AND MASSSPECTROMETRY. | |
