dbPTM

VPS73_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VPS73_YEAST
UniProt AC	P53142
Protein Name	Vacuolar protein sorting-associated protein 73
Gene Name	VPS73
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	486
Subcellular Localization	Mitochondrion membrane Multi-pass membrane protein .
Protein Description	May be involved in vacuolar protein sorting..
Protein Sequence	MNRILSSASLLSNVSMPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEGYPYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVGSLIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVLLTQGIALPLTDSYRWRWILFGSFLIAVLNFFMWFIVDESPKWLLAHGRVTDAKLSLCKLRGVTFDEAAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNVKSRHVITVLLFGQQFCGINSIVLYGTKIISQLYPQHAIRINFFISMVNVLVTILVSLLIHSLPRKPLLMTSTVLVSVTAFIMGIAMNHNKMNLLIVFSFIYMGVFTMGLNPLPFIIMREVSKPQDMVLAQRYGTICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIACSISAFIWKKVPETKRSG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNRILSSASLLSN --CCCCCCHHHHHHC	22.83	22369663
7	Phosphorylation	-MNRILSSASLLSNV -CCCCCCHHHHHHCC	20.59	22369663
9	Phosphorylation	NRILSSASLLSNVSM CCCCCHHHHHHCCCC	31.61	22369663
12	Phosphorylation	LSSASLLSNVSMPRQ CCHHHHHHCCCCCCC	40.24	23749301
15	Phosphorylation	ASLLSNVSMPRQNKH HHHHHCCCCCCCCHH	27.59	23749301
231	Phosphorylation	MWFIVDESPKWLLAH HHHHHCCCCCHHHHC	27.58	27717283
245	Ubiquitination	HGRVTDAKLSLCKLR CCCCCHHHHHHHHHC	41.22	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VPS73_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VPS73_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VPS73_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GST1_YEAST	GTT1	physical	18719252
UIP3_YEAST	UIP3	physical	18719252
PEX29_YEAST	PEX29	physical	18719252
MDL2_YEAST	MDL2	physical	16093310
YAJ8_YEAST	YAR028W	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
GPI8_YEAST	GPI8	physical	16093310
GMT1_YEAST	VRG4	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
MRS3_YEAST	MRS3	physical	16093310
STE24_YEAST	STE24	physical	16093310
YET1_YEAST	YET1	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
GSF2_YEAST	GSF2	physical	16093310
HMDH1_YEAST	HMG1	physical	16093310
CUE1_YEAST	CUE1	physical	16093310
VAC7_YEAST	VAC7	physical	16093310
ERP4_YEAST	ERP4	physical	16093310
GPI2_YEAST	GPI2	physical	16093310
GPI3_YEAST	SPT14	physical	16093310
YOP1_YEAST	YOP1	physical	16093310
SNF5_YEAST	SNF5	genetic	27708008
MCM7_YEAST	MCM7	genetic	27708008
SAD1_YEAST	SAD1	genetic	27708008
FDFT_YEAST	ERG9	genetic	27708008
ARP3_YEAST	ARP3	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
CWC16_YEAST	YJU2	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
SWD1_YEAST	SWD1	genetic	27708008
SGF29_YEAST	SGF29	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
RRP8_YEAST	RRP8	genetic	27708008
OPI1_YEAST	OPI1	genetic	27708008
HTD2_YEAST	HTD2	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
FABG_YEAST	OAR1	genetic	27708008
KASH5_HUMAN	CCDC155	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VPS73_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.	18407956 [Abstract]