KICH_YEAST - dbPTM
KICH_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KICH_YEAST
UniProt AC P20485
Protein Name Choline kinase
Gene Name CKI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 582
Subcellular Localization Cytoplasm.
Protein Description Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline..
Protein Sequence MVQESRPGSVRSYSVGYQARSRSSSQRRHSLTRQRSSQRLIRTISIESDVSNITDDDDLRAVNEGVAGVQLDVSETANKGPRRASATDVTDSLGSTSSEYIEIPFVKETLDASLPSDYLKQDILNLIQSLKISKWYNNKKIQPVAQDMNLVKISGAMTNAIFKVEYPKLPSLLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNSQRIARRMKELHVGVPLLSSERKNGSACWQKINQWLRTIEKVDQWVGDPKNIENSLLCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPSSTSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDYNNAKAPHQCHADRYPDKEQVLNFLYSYVSHLRGGAKEPIDEEVQRLYKSIIQWRPTVQLFWSLWAILQSGKLEKKEASTAITREEIGPNGKKYIIKTEPESPEEDFVENDDEPEAGVSIDTFDYMAYGRDKIAVFWGDLIGLGIITEEECKNFSSFKFLDTSYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MVQESRPGSVRS
---CCCCCCCCCCEE		27.0430377154
9PhosphorylationVQESRPGSVRSYSVG
CCCCCCCCCEEECCE		19.6228889911
12PhosphorylationSRPGSVRSYSVGYQA
CCCCCCEEECCEEEE		21.4322890988
13PhosphorylationRPGSVRSYSVGYQAR
CCCCCEEECCEEEEC		9.2322890988
14PhosphorylationPGSVRSYSVGYQARS
CCCCEEECCEEEECC		15.4322369663
17PhosphorylationVRSYSVGYQARSRSS
CEEECCEEEECCCCH		9.2422890988
25PhosphorylationQARSRSSSQRRHSLT
EECCCCHHHHHHCHH		29.0228889911
30PhosphorylationSSSQRRHSLTRQRSS
CHHHHHHCHHHHHHH		29.6228889911
37PhosphorylationSLTRQRSSQRLIRTI
CHHHHHHHHHHHHEE		22.8528889911
43PhosphorylationSSQRLIRTISIESDV
HHHHHHHEEEEECCH		16.4522890988
45PhosphorylationQRLIRTISIESDVSN
HHHHHEEEEECCHHC		21.4921082442
48PhosphorylationIRTISIESDVSNITD
HHEEEEECCHHCCCC		41.4622890988
51PhosphorylationISIESDVSNITDDDD
EEEECCHHCCCCHHH		27.7519795423
54PhosphorylationESDVSNITDDDDLRA
ECCHHCCCCHHHHHH		37.3119795423
85PhosphorylationNKGPRRASATDVTDS
CCCCCCCCCCCCCCC		29.8622369663
87PhosphorylationGPRRASATDVTDSLG
CCCCCCCCCCCCCCC		28.6222369663
90PhosphorylationRASATDVTDSLGSTS
CCCCCCCCCCCCCCC		23.7622369663
92PhosphorylationSATDVTDSLGSTSSE
CCCCCCCCCCCCCCC		25.8422369663
95PhosphorylationDVTDSLGSTSSEYIE
CCCCCCCCCCCCEEE		30.3422369663
96PhosphorylationVTDSLGSTSSEYIEI
CCCCCCCCCCCEEEC		34.1822369663
97PhosphorylationTDSLGSTSSEYIEIP
CCCCCCCCCCEEECC		23.9122369663
98PhosphorylationDSLGSTSSEYIEIPF
CCCCCCCCCEEECCC		34.2122369663
100PhosphorylationLGSTSSEYIEIPFVK
CCCCCCCEEECCCCC		13.0522369663
131AcetylationLNLIQSLKISKWYNN
HHHHHHHCCHHHHCC		50.6224489116
168UbiquitinationIFKVEYPKLPSLLLR
EEECCCCCCCHHHHH		72.6124961812
168AcetylationIFKVEYPKLPSLLLR
EEECCCCCCCHHHHH		72.6124489116
198PhosphorylationLQILARLSLKNIGPS
HHHHHHHHHCCCCHH		31.5728889911
236PhosphorylationDIRNWKNSQRIARRM
HHHHHHHHHHHHHHH		19.6728889911
273PhosphorylationKINQWLRTIEKVDQW
HHHHHHHHHHHHHHH		31.1728889911
276AcetylationQWLRTIEKVDQWVGD
HHHHHHHHHHHHHCC		47.4624489116
454UbiquitinationSHLRGGAKEPIDEEV
HHHCCCCCCCCCHHH		68.2623749301
515PhosphorylationGKKYIIKTEPESPEE
CCEEEEECCCCCCHH		46.4924961812
519PhosphorylationIIKTEPESPEEDFVE
EEECCCCCCHHHCCC		48.6124961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
30SPhosphorylationKinasePKA-FAMILY-GPS
30SPhosphorylationKinasePKA-Uniprot
85SPhosphorylationKinasePKA-FAMILY-GPS
85SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KICH_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KICH_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KC11_YEASTYCK1genetic
1627830
EKI1_YEASTEKI1genetic
10329685
KCS1_YEASTKCS1genetic
19269370
KHSE_YEASTTHR1genetic
19269370
PLMT_YEASTOPI3genetic
19269370
ADK_YEASTADO1genetic
19269370
SAC1_YEASTSAC1genetic
19269370
IES3_YEASTIES3genetic
19269370
PFD5_YEASTGIM5genetic
19269370
SPO14_YEASTSPO14genetic
19146388
SYUA_HUMANSNCAgenetic
19146388
EKI1_YEASTEKI1genetic
18408719
KAPA_YEASTTPK1physical
16751660
INO2_YEASTINO2genetic
20093466
YFF2_YEASTYFL052Wgenetic
20093466
ASK10_YEASTASK10genetic
20093466
CHO2_YEASTCHO2genetic
20093466
THIK_YEASTPOT1genetic
20093466
PLMT_YEASTOPI3genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
MSB4_YEASTMSB4genetic
20093466
DGK1_YEASTDGK1genetic
20093466
PRM4_YEASTPRM4genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
NAP1_YEASTNAP1physical
20489023
CSR1_YEASTCSR1genetic
16262726
SFH5_YEASTSFH5genetic
16262726
SPO14_YEASTSPO14genetic
15560781
POS5_YEASTPOS5genetic
21623372
COX7_YEASTCOX7genetic
21623372
ADK_YEASTADO1genetic
21623372
REI1_YEASTREI1genetic
21127252
VMS1_YEASTVMS1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
MET18_YEASTMET18genetic
21127252
PP4C_YEASTPPH3genetic
21127252
INO2_YEASTINO2genetic
21127252
XBP1_YEASTXBP1genetic
21127252
RGT1_YEASTRGT1genetic
21127252
YEW0_YEASTCOM2genetic
21127252
RAD5_YEASTRAD5genetic
21127252
ATC3_YEASTDRS2genetic
21987634
UBP4_YEASTDOA4genetic
21987634
RGP1_YEASTRGP1genetic
21987634
VPS52_YEASTVPS52genetic
21987634
GABAT_YEASTUGA1genetic
21987634
CHO2_YEASTCHO2genetic
21987634
GEP4_YEASTGEP4genetic
21987634
ICE2_YEASTICE2genetic
21987634
PLMT_YEASTOPI3genetic
21987634
VPH2_YEASTVPH2genetic
21987634
LAS1_YEASTLAS1genetic
21987634
RIC1_YEASTRIC1genetic
21987634
YPT6_YEASTYPT6genetic
21987634
INO4_YEASTINO4genetic
21987634
GEP3_YEASTGEP3genetic
21987634
DGK1_YEASTDGK1genetic
21987634
YME1_YEASTYME1genetic
21987634
YPC1_YEASTYPC1genetic
22341443
NAP1_YEASTNAP1physical
18086883
ICE2_YEASTICE2genetic
23891562
DGK1_YEASTDGK1genetic
23891562
GPR1_YEASTGPR1genetic
27708008
ASK10_YEASTASK10genetic
27708008
ALG14_YEASTALG14genetic
27708008
CDC10_YEASTCDC10genetic
27708008
RPN5_YEASTRPN5genetic
27708008
GLE1_YEASTGLE1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
ORC6_YEASTORC6genetic
27708008
RFC2_YEASTRFC2genetic
27708008
NOC3_YEASTNOC3genetic
27708008
NSE5_YEASTNSE5genetic
27708008
POB3_YEASTPOB3genetic
27708008
VTI1_YEASTVTI1genetic
27708008
THIL_YEASTERG10genetic
27708008
CET1_YEASTCET1genetic
27708008
INO2_YEASTINO2genetic
27708008
CHO2_YEASTCHO2genetic
27708008
THIK_YEASTPOT1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
MGR3_YEASTMGR3genetic
27708008
EAF7_YEASTEAF7genetic
27708008
MSB4_YEASTMSB4genetic
27708008
FABD_YEASTMCT1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KICH_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-51; THR-54;SER-85; SER-95; THR-96; SER-97 AND SER-98, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; THR-90 AND SER-92,AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-85, AND MASSSPECTROMETRY.
"Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30and Ser85 by protein kinase A regulates phosphatidylcholine synthesisby the CDP-choline pathway.";
Yu Y., Sreenivas A., Ostrander D.B., Carman G.M.;
J. Biol. Chem. 277:34978-34986(2002).
Cited for: PHOSPHORYLATION AT SER-30 AND SER-85, AND MUTAGENESIS OF SER-30 ANDSER-85.

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