FOX2_YEAST - dbPTM
FOX2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOX2_YEAST
UniProt AC Q02207
Protein Name Peroxisomal hydratase-dehydrogenase-epimerase
Gene Name FOX2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 900
Subcellular Localization Peroxisome.
Protein Description Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA..
Protein Sequence MPGNLSFKDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIKKAGGIAVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFASVVDVHLTGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAKYNINVNSIAPLARSRMTENVLPPHILKQLGPEKIVPLVLYLTHESTKVSNSIFELAAGFFGQLRWERSSGQIFNPDPKTYTPEAILNKWKEITDYRDKPFNKTQHPYQLSDYNDLITKAKKLPPNEQGSVKIKSLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSHDVVTEAPLIIQTAISKFQRVDILVNNAGILRDKSFLKMKDEEWFAVLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAKRGIIVNVIAPHAETAMTKTIFSEKELSNHFDASQVSPLVVLLASEELQKYSGRRVIGQLFEVGGGWCGQTRWQRSSGYVSIKETIEPEEIKENWNHITDFSRNTINPSSTEESSMATLQAVQKAHSSKELDDGLFKYTTKDCILYNLGLGCTSKELKYTYENDPDFQVLPTFAVIPFMQATATLAMDNLVDNFNYAMLLHGEQYFKLCTPTMPSNGTLKTLAKPLQVLDKNGKAALVVGGFETYDIKTKKLIAYNEGSFFIRGAHVPPEKEVRDGKRAKFAVQNFEVPHGKVPDFEAEISTNKDQAALYRLSGDFNPLHIDPTLAKAVKFPTPILHGLCTLGISAKALFEHYGPYEELKVRFTNVVFPGDTLKVKAWKQGSVVVFQTIDTTRNVIVLDNAAVKLSQAKSKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48PhosphorylationLGGTLGGSGHNSKAA
CCCCCCCCCCCHHHH		34.7727214570
52PhosphorylationLGGSGHNSKAADLVV
CCCCCCCHHHHHHHH		20.2827214570
152PhosphorylationGRIINTASPAGLFGN
CCHHCCCCCCCCCCC		17.1627214570
266PhosphorylationNPDPKTYTPEAILNK
CCCCCCCCHHHHHHH		21.6427214570
288PhosphorylationRDKPFNKTQHPYQLS
CCCCCCCCCCCCCCC		32.9619823750
295PhosphorylationTQHPYQLSDYNDLIT
CCCCCCCCCHHHHHH		23.6419823750
297PhosphorylationHPYQLSDYNDLITKA
CCCCCCCHHHHHHHH		13.7519823750
302PhosphorylationSDYNDLITKAKKLPP
CCHHHHHHHHHCCCC		32.0419823750
319PhosphorylationQGSVKIKSLCNKVVV
CCCHHHHHHCCCEEE		41.4428889911
565PhosphorylationQTRWQRSSGYVSIKE
CCCCCCCCCEEEEEE		36.0127214570
698PhosphorylationEQYFKLCTPTMPSNG
CEEEEECCCCCCCCC		32.0327214570
706PhosphorylationPTMPSNGTLKTLAKP
CCCCCCCCCHHHCHH		29.3627214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOX2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOX2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOX2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TTL_YEASTPBY1physical
16554755
CYK3_YEASTCYK3physical
16554755
RGA2_YEASTRGA2physical
16554755
PXA1_YEASTPXA1genetic
18757502
PXA2_YEASTPXA2genetic
18757502
THDH_YEASTILV1genetic
21623372
NU192_YEASTNUP192genetic
27708008
CDK1_YEASTCDC28genetic
27708008
TRS20_YEASTTRS20genetic
27708008
CDC10_YEASTCDC10genetic
27708008
DPOD_YEASTPOL3genetic
27708008
RPB1_YEASTRPO21genetic
27708008
TFB1_YEASTTFB1genetic
27708008
SEC20_YEASTSEC20genetic
27708008
COPD_YEASTRET2genetic
27708008
MED6_YEASTMED6genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CDC3_YEASTCDC3genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
LST8_YEASTLST8genetic
27708008
SMC5_YEASTSMC5genetic
27708008
RPB2_YEASTRPB2genetic
27708008
APC5_YEASTAPC5genetic
27708008
GPN2_YEASTGPN2genetic
27708008
SYA_YEASTALA1genetic
27708008
SEC62_YEASTSEC62genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOX2_YEAST

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Related Literatures of Post-Translational Modification

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