ARO9_YEAST - dbPTM
ARO9_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARO9_YEAST
UniProt AC P38840
Protein Name Aromatic amino acid aminotransferase 2
Gene Name ARO9
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 513
Subcellular Localization Cytoplasm .
Protein Description General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Mainly involved in tryptophan degradation. Active with phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate and pyruvate as amino acceptors. Does not accept glutamate or 2-oxoglutarate as substrates. Also active with methionine, leucine, glutamine and kynurenine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) with pyruvate as amino acceptor..
Protein Sequence MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTAGSAPPV
------CCCCCCCCC		39.4622369663
5Phosphorylation---MTAGSAPPVDYT
---CCCCCCCCCCHH		34.8322369663
15SuccinylationPVDYTSLKKNFQPFL
CCCHHHHHHHCHHHH		45.5023954790
41PhosphorylationFWDASDISDDVIELA
HHCHHHCCHHHHHHC		32.5230377154
80PhosphorylationDNPKWHNSFTTAHLD
CCCCCCCCCEEEEEC		15.8722369663
82PhosphorylationPKWHNSFTTAHLDLG
CCCCCCCEEEEECCC		23.9322369663
83PhosphorylationKWHNSFTTAHLDLGS
CCCCCCEEEEECCCC		15.2922369663
90PhosphorylationTAHLDLGSPSELPIA
EEEECCCCCCCCCCC		32.3322369663
92PhosphorylationHLDLGSPSELPIARS
EECCCCCCCCCCCHH		54.1622369663
299PhosphorylationLNDFLMKSFLTLDTD
HHHHHHHHHCCCCCC		16.1230377154
317AcetylationIRLETFSKIFAPGLR
EEHHHHHHHCCCCHH		37.3422865919
502PhosphorylationEASKRIGSGIKEFFD
HHHHHHCCHHHHHHH		34.6724909858
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARO9_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARO9_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARO9_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
6PGD1_YEASTGND1physical
16554755
YL278_YEASTYLR278Cphysical
16554755
ARO9_YEASTARO9physical
18719252
NHP10_YEASTNHP10genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
YB75_YEASTYBR225Wgenetic
27708008
SLX5_YEASTSLX5genetic
27708008
RXT3_YEASTRXT3genetic
27708008
VAM6_YEASTVAM6genetic
27708008
SWI6_YEASTSWI6genetic
27708008
RS3A1_YEASTRPS1Agenetic
27708008
BUL2_YEASTBUL2genetic
27708008
RE114_YEASTREC114genetic
27708008
YM24_YEASTYMR147Wgenetic
27708008
PFKA2_YEASTPFK2genetic
27708008
LSM7_YEASTLSM7genetic
27708008
THP3_YEASTTHP3genetic
27708008
CHMU_YEASTARO7genetic
27708008
UBA3_YEASTUBA3genetic
27708008
KAR3_YEASTKAR3genetic
27708008
VPS4_YEASTVPS4genetic
27708008
ARO8_YEASTARO8genetic
28939805
YEY2_YEASTYER152Cgenetic
28939805
ICE2_YEASTICE2genetic
29674565
SIN3_YEASTSIN3genetic
29674565
HAS1_YEASTHAS1genetic
29674565
YAR1_YEASTYAR1genetic
29674565
CKS1_YEASTCKS1genetic
29674565
SYS1_YEASTSYS1genetic
29674565
CSF1_YEASTCSF1genetic
29674565
PKR1_YEASTPKR1genetic
29674565
DFG5_YEASTDFG5genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARO9_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-90 AND SER-92,AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory