ISF1_YEAST - dbPTM
ISF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ISF1_YEAST
UniProt AC P32488
Protein Name Increasing suppression factor 1
Gene Name ISF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 338
Subcellular Localization
Protein Description Could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover. Participates in mitochondrial biogenesis..
Protein Sequence MIASEIFERGVQDPFCQDCDYEDETDVQSFLGSNDLNDFVNSKLASFSFQNSSKSNNSHHSSSTNAGNTSRHIGNHTIGHHLRKIKTAPHHLYGFVPANSTNNSNEPIRPSPRRIRANSSTLIHQLSRQSTRQSSLGDAADSCFDHKCIKPRSRHSSCYGIPTHLYGLEKYVSSELDSLAVANDQSNDLTSPLTSVSTPASNSNSYLNLNSSSAAYPSSYLSNEKNNRLKLISHGKISSNNVPGHSGNLNHYHRERTPSNLRRESFSLLSNGSSSSPLQTRNNSYSNSLVKSPSNSSLNTSVASSNEESSPHTSNCLEERNPRRKSFIKLSLASSFSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationFVNSKLASFSFQNSS
HHHHHHHHHCCCCCC		31.6822369663
48PhosphorylationNSKLASFSFQNSSKS
HHHHHHHCCCCCCCC		24.3522369663
52PhosphorylationASFSFQNSSKSNNSH
HHHCCCCCCCCCCCC		28.4922369663
53PhosphorylationSFSFQNSSKSNNSHH
HHCCCCCCCCCCCCC		47.8822369663
111PhosphorylationSNEPIRPSPRRIRAN
CCCCCCCCCCCCCCC		22.6130377154
119PhosphorylationPRRIRANSSTLIHQL
CCCCCCCHHHHHHHH		24.5822369663
120PhosphorylationRRIRANSSTLIHQLS
CCCCCCHHHHHHHHH		27.3422369663
121PhosphorylationRIRANSSTLIHQLSR
CCCCCHHHHHHHHHH		29.5622369663
127PhosphorylationSTLIHQLSRQSTRQS
HHHHHHHHHHCCCHH		23.0022369663
130PhosphorylationIHQLSRQSTRQSSLG
HHHHHHHCCCHHCHH		25.1728889911
134PhosphorylationSRQSTRQSSLGDAAD
HHHCCCHHCHHHHHH		25.0022369663
135PhosphorylationRQSTRQSSLGDAADS
HHCCCHHCHHHHHHH		28.2122369663
142PhosphorylationSLGDAADSCFDHKCI
CHHHHHHHHHCCCCC		16.3827017623
153PhosphorylationHKCIKPRSRHSSCYG
CCCCCCCCCCCCCCC		42.7622369663
156PhosphorylationIKPRSRHSSCYGIPT
CCCCCCCCCCCCCCH		22.4622369663
157PhosphorylationKPRSRHSSCYGIPTH
CCCCCCCCCCCCCHH		12.7722369663
159PhosphorylationRSRHSSCYGIPTHLY
CCCCCCCCCCCHHHH		21.7522369663
163PhosphorylationSSCYGIPTHLYGLEK
CCCCCCCHHHHCHHH		23.6919779198
233PhosphorylationNNRLKLISHGKISSN
CCCEEEEECCCCCCC		36.3028889911
265PhosphorylationPSNLRRESFSLLSNG
CCHHHHHHEEECCCC		20.5122369663
267PhosphorylationNLRRESFSLLSNGSS
HHHHHHEEECCCCCC		37.3722369663
270PhosphorylationRESFSLLSNGSSSSP
HHHEEECCCCCCCCC		44.4222369663
273PhosphorylationFSLLSNGSSSSPLQT
EEECCCCCCCCCCCC		31.1522369663
274PhosphorylationSLLSNGSSSSPLQTR
EECCCCCCCCCCCCC		35.9122369663
275PhosphorylationLLSNGSSSSPLQTRN
ECCCCCCCCCCCCCC		37.3622369663
276PhosphorylationLSNGSSSSPLQTRNN
CCCCCCCCCCCCCCC		31.4222369663
280PhosphorylationSSSSPLQTRNNSYSN
CCCCCCCCCCCCCCC		42.9422369663
284PhosphorylationPLQTRNNSYSNSLVK
CCCCCCCCCCCCCCC		33.2222369663
285PhosphorylationLQTRNNSYSNSLVKS
CCCCCCCCCCCCCCC		17.6222369663
286PhosphorylationQTRNNSYSNSLVKSP
CCCCCCCCCCCCCCC		21.5522369663
288PhosphorylationRNNSYSNSLVKSPSN
CCCCCCCCCCCCCCC		28.7122369663
292PhosphorylationYSNSLVKSPSNSSLN
CCCCCCCCCCCCCCC		26.5319779198
294PhosphorylationNSLVKSPSNSSLNTS
CCCCCCCCCCCCCCC		57.3319779198
296PhosphorylationLVKSPSNSSLNTSVA
CCCCCCCCCCCCCCC		40.3130377154
297PhosphorylationVKSPSNSSLNTSVAS
CCCCCCCCCCCCCCC		29.8628889911
301PhosphorylationSNSSLNTSVASSNEE
CCCCCCCCCCCCCCC		18.0219779198
304PhosphorylationSLNTSVASSNEESSP
CCCCCCCCCCCCCCC		31.3819779198
309PhosphorylationVASSNEESSPHTSNC
CCCCCCCCCCCHHCH		42.8830377154
334PhosphorylationFIKLSLASSFSN---
HHHHHHHHHCCC---		36.8930377154
335PhosphorylationIKLSLASSFSN----
HHHHHHHHCCC----		27.3828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ISF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ISF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ISF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG1_YEASTATG1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
APC11_YEASTAPC11genetic
27708008
RPB1_YEASTRPO21genetic
27708008
CDC20_YEASTCDC20genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MET30_YEASTMET30genetic
27708008
MCM10_YEASTMCM10genetic
27708008
ARP4_YEASTARP4genetic
27708008
KTHY_YEASTCDC8genetic
27708008
SMC4_YEASTSMC4genetic
27708008
NEP1_YEASTEMG1genetic
27708008
HRP1_YEASTHRP1genetic
27708008
MOT1_YEASTMOT1genetic
27708008
AVT5_YEASTAVT5genetic
27708008
RV161_YEASTRVS161genetic
27708008
MDM34_YEASTMDM34genetic
27708008
RTG2_YEASTRTG2genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
TOP1_YEASTTOP1genetic
27708008
DCAM_YEASTSPE2genetic
27708008
DIA2_YEASTDIA2genetic
27708008
HAT1_YEASTHAT1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ISF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119 AND SER-284, ANDMASS SPECTROMETRY.

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