ERFB_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERFB_YEAST
• UniProt AC: Q06551
• Protein Name: Palmitoyltransferase ERF2
• Gene Name: ERF2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 359
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization..
• Protein Sequence: MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYIFFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGHLMLEPRGPSFVSARKPHEAGDWRFMDLSPAHSFEKIQKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
203	S-palmitoylation	VMVHDHHCIWVNNCI EEECCCCEEEEECCC	2.05	20851885
313	Phosphorylation	ENIYNKGSFLKNMGH HCCCCCCHHHHHHCE	29.08	27017623
329	Phosphorylation	MLEPRGPSFVSARKP EECCCCCCCCCCCCC	40.90	27017623
332	Phosphorylation	PRGPSFVSARKPHEA CCCCCCCCCCCCCCC	21.98	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERFB_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERFB_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERFB_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERFD_YEAST	SHR5	physical	12379641
CTR2_YEAST	CTR2	genetic	16269340
GPT2_YEAST	GPT2	genetic	16269340
STE14_YEAST	STE14	genetic	16269340
PLMT_YEAST	OPI3	genetic	16269340
COPB2_YEAST	SEC27	genetic	16269340
COPE_YEAST	SEC28	genetic	16269340
VAC8_YEAST	VAC8	physical	19416974
YGK8_YEAST	YGL108C	physical	19416974
YBF9_YEAST	YBL059W	genetic	20093466
AGP1_YEAST	AGP1	genetic	20093466
SGF29_YEAST	SGF29	genetic	20093466
SLX5_YEAST	SLX5	genetic	20093466
RLA4_YEAST	RPP2B	genetic	20093466
STP1_YEAST	STP1	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
ATG1_YEAST	ATG1	genetic	20093466
VMA21_YEAST	VMA21	genetic	20093466
IRE1_YEAST	IRE1	genetic	20093466
THIK_YEAST	POT1	genetic	20093466
DCOR_YEAST	SPE1	genetic	20093466
YM79_YEAST	YMR244W	genetic	20093466
SNAPN_YEAST	SNN1	genetic	20093466
YN8H_YEAST	YNR029C	genetic	20093466
IRA2_YEAST	IRA2	genetic	20093466
RAS2_YEAST	RAS2	physical	22904317
ATG1_YEAST	ATG1	genetic	22282571
ERFB_YEAST	ERF2	physical	27009891
ASND1_YEAST	YML096W	genetic	27708008
PLB2_YEAST	PLB2	genetic	27708008
MBA1_YEAST	MBA1	genetic	27708008
SGF29_YEAST	SGF29	genetic	27708008
AGP1_YEAST	AGP1	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
PP2C1_YEAST	PTC1	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
SWF1_YEAST	SWF1	genetic	27708008
RLA4_YEAST	RPP2B	genetic	27708008
STP1_YEAST	STP1	genetic	27708008
ATG1_YEAST	ATG1	genetic	27708008
LRP1_YEAST	LRP1	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
UBI4P_YEAST	UBI4	genetic	27708008
RS3A1_YEAST	RPS1A	genetic	27708008
OGG1_YEAST	OGG1	genetic	27708008
DAK1_YEAST	DAK1	genetic	27708008
ATP18_YEAST	ATP18	genetic	27708008
PALI_YEAST	RIM9	genetic	27708008
YMY9_YEAST	YMR099C	genetic	27708008
MLH1_YEAST	MLH1	genetic	27708008
RAD14_YEAST	RAD14	genetic	27708008
PFKA2_YEAST	PFK2	genetic	27708008
YM79_YEAST	YMR244W	genetic	27708008
YN8H_YEAST	YNR029C	genetic	27708008
MSB4_YEAST	MSB4	genetic	27708008
VPS17_YEAST	VPS17	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.