PSO2_YEAST - dbPTM
PSO2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSO2_YEAST
UniProt AC P30620
Protein Name DNA cross-link repair protein PSO2/SNM1
Gene Name PSO2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 661
Subcellular Localization Nucleus .
Protein Description Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein has 5' exonuclease activity on single-stranded and double-stranded DNA, which appears to be necessary for the processing of DNA double strand breaks prior to ligation..
Protein Sequence MSRKSIVQIRRSEVKRKRSSTASSTSEGKTLHKNTHTSSKRQRTLTEFNIPTSSNLPVRSSSYSFSRFSCSTSNKNTEPVIINDDDHNSICLEDTAKVEITIDTDEEELVSLHDNEVSAIENRTEDRIVTELEEQVNVKVSTEVIQCPICLENLSHLELYERETHCDTCIGSDPSNMGTPKKNIRSFISNPSSPAKTKRDIATSKKPTRVKLVLPSFKIIKFNNGHEIVVDGFNYKASETISQYFLSHFHSDHYIGLKKSWNNPDENPIKKTLYCSKITAILVNLKFKIPMDEIQILPMNKRFWITDTISVVTLDANHCPGAIIMLFQEFLANSYDKPIRQILHTGDFRSNAKMIETIQKWLAETANETIDQVYLDTTYMTMGYNFPSQHSVCETVADFTLRLIKHGKNKTFGDSQRNLFHFQRKKTLTTHRYRVLFLVGTYTIGKEKLAIKICEFLKTKLFVMPNSVKFSMMLTVLQNNENQNDMWDESLLTSNLHESSVHLVPIRVLKSQETIEAYLKSLKELETDYVKDIEDVVGFIPTGWSHNFGLKYQKKNDDDENEMSGNTEYCLELMKNDRDNDDENGFEISSILRQYKKYNKFQVFNVPYSEHSSFNDLVKFGCKLKCSEVIPTVNLNNLWKVRYMTNWFQCWENVRKTRAAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
172PhosphorylationHCDTCIGSDPSNMGT
CCCCCCCCCHHHCCC		26.8323749301
175PhosphorylationTCIGSDPSNMGTPKK
CCCCCCHHHCCCCCH		44.4323749301
179PhosphorylationSDPSNMGTPKKNIRS
CCHHHCCCCCHHHHH		22.5923749301
186PhosphorylationTPKKNIRSFISNPSS
CCCHHHHHHHHCCCC		24.1224961812
189PhosphorylationKNIRSFISNPSSPAK
HHHHHHHHCCCCCCC		40.4522369663
192PhosphorylationRSFISNPSSPAKTKR
HHHHHCCCCCCCCHH		53.8820377248
193PhosphorylationSFISNPSSPAKTKRD
HHHHCCCCCCCCHHH		30.0822369663
204PhosphorylationTKRDIATSKKPTRVK
CHHHHCCCCCCCEEE		29.6527017623
260PhosphorylationHYIGLKKSWNNPDEN
CEECCCCCCCCCCCC		33.1925704821
433PhosphorylationKTLTTHRYRVLFLVG
CCCCCCCEEEEEEEE		9.4728889911
442PhosphorylationVLFLVGTYTIGKEKL
EEEEEEEEECCHHHH		7.1628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSO2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSO2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSO2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MG101_YEASTMGM101physical
11805837
PP2C7_YEASTPTC7physical
11805837
FEN1_YEASTRAD27genetic
15743825
MRE11_YEASTMRE11genetic
15743825
EXO1_YEASTEXO1genetic
15743825
MSH2_YEASTMSH2genetic
15743825
MSH6_YEASTMSH6genetic
15743825
MLH1_YEASTMLH1genetic
15743825
KU80_YEASTYKU80genetic
17314980
NUP84_YEASTNUP84genetic
17314980
SWD3_YEASTSWD3genetic
17314980
DPOZ_YEASTREV3genetic
11738934
RAD51_YEASTRAD51genetic
11738934
COX11_YEASTCOX11genetic
14963816
MSH2_YEASTMSH2genetic
18006388
EXO1_YEASTEXO1genetic
18295552
MRE11_YEASTMRE11genetic
18295552
RAD5_YEASTRAD5genetic
18295552
RAD3_YEASTRAD3genetic
7026532
RAD52_YEASTRAD52genetic
7026532
UBC2_YEASTRAD6genetic
7026532
MPH1_YEASTMPH1genetic
22912599
MG101_YEASTMGM101genetic
22912599
MSH6_YEASTMSH6genetic
22912599
MSH2_YEASTMSH2genetic
22912599
KU70_YEASTYKU70genetic
22912599
EXO1_YEASTEXO1genetic
22912599
CHL1_YEASTCHL1genetic
22912599
SLX4_YEASTSLX4genetic
22912599
SAK1_YEASTSAK1physical
24362320
KRR1_YEASTKRR1genetic
27708008
ARP2_YEASTARP2genetic
27708008
CDC13_YEASTCDC13genetic
27708008
SEC7_YEASTSEC7genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC23_YEASTCDC23genetic
27708008
PSF2_YEASTPSF2genetic
27708008
NCA3_YEASTNCA3genetic
27708008
DHOM_YEASTHOM6genetic
27708008
TAF5_YEASTTAF5genetic
27708008
LCB2_YEASTLCB2genetic
27708008
TAF12_YEASTTAF12genetic
27708008
RPB7_YEASTRPB7genetic
27708008
SAD1_YEASTSAD1genetic
27708008
TAF6_YEASTTAF6genetic
27708008
SLD3_YEASTSLD3genetic
27708008
GPI10_YEASTGPI10genetic
27708008
PGTB1_YEASTCDC43genetic
27708008
RPC9_YEASTRPC17genetic
27708008
ARP4_YEASTARP4genetic
27708008
DPB11_YEASTDPB11genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC3_YEASTCDC3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
DBP6_YEASTDBP6genetic
27708008
MVD1_YEASTMVD1genetic
27708008
BRX1_YEASTBRX1genetic
27708008
DPM1_YEASTDPM1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
ECM33_YEASTECM33genetic
27708008
ICS2_YEASTICS2genetic
27708008
FAT2_YEASTPCS60genetic
27708008
SWC5_YEASTSWC5genetic
27708008
GPX2_YEASTGPX2genetic
27708008
SHG1_YEASTSHG1genetic
27708008
RIM1_YEASTRIM1genetic
27708008
SOL2_YEASTSOL2genetic
27708008
LHP1_YEASTLHP1genetic
27708008
CG23_YEASTCLB3genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RM01_YEASTMRPL1genetic
27708008
NACB2_YEASTBTT1genetic
27708008
PMP3_YEASTPMP3genetic
27708008
LCMT1_YEASTPPM1genetic
27708008
PAC11_YEASTPAC11genetic
27708008
RAD4_YEASTRAD4genetic
27708008
IES1_YEASTIES1genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
ECL1_YEASTECL1genetic
27708008
PHB2_YEASTPHB2genetic
27708008
TNA1_YEASTTNA1genetic
27708008
ARP1_YEASTARP1genetic
27708008
STB5_YEASTSTB5genetic
27708008
ASF1_YEASTASF1genetic
27708008
RAV1_YEASTRAV1genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
UBL1_YEASTYUH1genetic
27708008
ILM1_YEASTILM1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
MRT4_YEASTMRT4genetic
27708008
ELM1_YEASTELM1genetic
27708008
HSL1_YEASTHSL1genetic
27708008
RM49_YEASTMRP49genetic
27708008
PTK1_YEASTPTK1genetic
27708008
MIC60_YEASTMIC60genetic
27708008
NU133_YEASTNUP133genetic
27708008
TPO1_YEASTTPO1genetic
27708008
LDB18_YEASTLDB18genetic
27708008
BRE2_YEASTBRE2genetic
27708008
YL046_YEASTYLR046Cgenetic
27708008
ACE2_YEASTACE2genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
ROM2_YEASTROM2genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
PET8_YEASTPET8genetic
27708008
COG5_YEASTCOG5genetic
27708008
NST1_YEASTNST1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
SIN3_YEASTSIN3genetic
27708008
2A5D_YEASTRTS1genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
LIS1_YEASTPAC1genetic
27708008
VTS1_YEASTVTS1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
RNY1_YEASTRNY1genetic
27708008
COX10_YEASTCOX10genetic
27708008
CG22_YEASTCLB2genetic
27708008
FEN1_YEASTRAD27genetic
28628639
MSH2_YEASTMSH2genetic
28628639
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSO2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND SER-193, ANDMASS SPECTROMETRY.

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