YD239_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YD239_YEAST
• UniProt AC: Q03780
• Protein Name: Uncharacterized protein YDR239C
• Gene Name: YDR239C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 787
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MFDGFSNNKGKRRSFFRFGSESKNNDSEKSVRKPSVPSTIKKSTNIARTSTAETSAPDIPPRSPNRNAHSRSHSIQAPLQKETLKNTNPFLNAEDTLGDSLELTQSKEASGNDHKGIEYLQENNIIGQRTNPFTTSANSNAHFSKIKRSRPPPPPMDMKSITTSISNNTTKEEIESNNDSERDSIAISSTHNQHRRQRSEAEKLVDDIENYINEHKVSSGSSLSLDTSENSDTKASQDKLPVDVMEAPILRNVSAESSLSYVKPLIVDNEEVNKASNGNLVQSDHLKEFSSNLDDGDDKFSFSTSASGKSTKSLQQVSKDESSGFKAAHFDFAYKSNEHLGSDGSIASARKPLRITNEIDSGSSNEDDDDGLQEKGFVDSESKAFINYASDQGSSIKNDVSTQEPELPSHRRIFRVVNEDRPSFYLNSVNDTGSLTDKHSFDTASSGEYDAKSNFSSQSGLSISKGSKSTVLAALDSNGNTKSSNKTSELNSLNSISESLVPAAHSFNEHTVTIPATVDLPNPVHDAPSERSVKCSPLTSVVSNKSEKSVPLVSSYVEELRLKYYKTSNFLQAPPNLPVALKQKNNLIQPKNIKVKLRTSSKQIGIKHGKVKQKLLALETRNEESDGTATGLKNKINVDHTKEFHKLLGKENETGSISKKEGTDAEQAEDYLKDIPGDEAYNSDDIMAPLREKRGQNGSVDSVSRSNTVVSYYTRSQNRMRSGTLDNDYVNRQKLPTHISLQDYRDANARSNISRQDSVSTTNSDVVDLSYSLGHGLRVANPDSDPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFDGFSNN -------CCCCCCCC	6.61	22814378
6	Phosphorylation	--MFDGFSNNKGKRR --CCCCCCCCCCCCC	45.05	30377154
20	Phosphorylation	RSFFRFGSESKNNDS CCEEECCCCCCCCCC	35.66	23749301
27	Phosphorylation	SESKNNDSEKSVRKP CCCCCCCCCCCCCCC	49.39	28889911
33	Ubiquitination	DSEKSVRKPSVPSTI CCCCCCCCCCCCCHH	39.22	23749301
35	Phosphorylation	EKSVRKPSVPSTIKK CCCCCCCCCCCHHHH	50.09	21440633
38	Phosphorylation	VRKPSVPSTIKKSTN CCCCCCCCHHHHCCC	40.38	23749301
49	Phosphorylation	KSTNIARTSTAETSA HCCCCCCCCCCCCCC	22.77	24961812
50	Phosphorylation	STNIARTSTAETSAP CCCCCCCCCCCCCCC	21.77	24961812
51	Phosphorylation	TNIARTSTAETSAPD CCCCCCCCCCCCCCC	28.09	23749301
54	Phosphorylation	ARTSTAETSAPDIPP CCCCCCCCCCCCCCC	27.94	24961812
55	Phosphorylation	RTSTAETSAPDIPPR CCCCCCCCCCCCCCC	29.34	28132839
63	Phosphorylation	APDIPPRSPNRNAHS CCCCCCCCCCCCCCC	32.09	21082442
70	Phosphorylation	SPNRNAHSRSHSIQA CCCCCCCCCCCCCCC	32.82	19684113
72	Phosphorylation	NRNAHSRSHSIQAPL CCCCCCCCCCCCCCC	25.30	22369663
74	Phosphorylation	NAHSRSHSIQAPLQK CCCCCCCCCCCCCCH	20.03	22369663
104	Phosphorylation	LGDSLELTQSKEASG CCCCEEHHCCCCCCC	22.78	28152593
106	Phosphorylation	DSLELTQSKEASGND CCEEHHCCCCCCCCC	27.51	28132839
110	Phosphorylation	LTQSKEASGNDHKGI HHCCCCCCCCCCCCH	38.94	21551504
130	Phosphorylation	NNIIGQRTNPFTTSA CCCCCCCCCCCCCCC	39.08	21551504
134	Phosphorylation	GQRTNPFTTSANSNA CCCCCCCCCCCCCCC	22.54	21551504
135	Phosphorylation	QRTNPFTTSANSNAH CCCCCCCCCCCCCCC	26.65	21551504
145	Acetylation	NSNAHFSKIKRSRPP CCCCCHHHCCCCCCC	51.83	24489116
149	Phosphorylation	HFSKIKRSRPPPPPM CHHHCCCCCCCCCCC	44.10	19779198
160	Phosphorylation	PPPMDMKSITTSISN CCCCCHHHHEEECCC	20.66	22369663
162	Phosphorylation	PMDMKSITTSISNNT CCCHHHHEEECCCCC	22.91	22369663
163	Phosphorylation	MDMKSITTSISNNTT CCHHHHEEECCCCCC	23.53	22369663
164	Phosphorylation	DMKSITTSISNNTTK CHHHHEEECCCCCCH	18.50	22369663
166	Phosphorylation	KSITTSISNNTTKEE HHHEEECCCCCCHHH	24.64	22369663
169	Phosphorylation	TTSISNNTTKEEIES EEECCCCCCHHHHHH	43.42	22369663
170	Phosphorylation	TSISNNTTKEEIESN EECCCCCCHHHHHHC	38.28	22369663
176	Phosphorylation	TTKEEIESNNDSERD CCHHHHHHCCCCCCC	46.74	28889911
180	Phosphorylation	EIESNNDSERDSIAI HHHHCCCCCCCEEEE	36.33	29136822
184	Phosphorylation	NNDSERDSIAISSTH CCCCCCCEEEEHHHH	21.82	29136822
188	Phosphorylation	ERDSIAISSTHNQHR CCCEEEEHHHHHHHH	21.84	24961812
189	Phosphorylation	RDSIAISSTHNQHRR CCEEEEHHHHHHHHH	27.80	24961812
190	Phosphorylation	DSIAISSTHNQHRRQ CEEEEHHHHHHHHHH	20.32	24961812
199	Phosphorylation	NQHRRQRSEAEKLVD HHHHHHHHHHHHHHH	32.59	24961812
218	Phosphorylation	YINEHKVSSGSSLSL HHHHCCCCCCCCCEE	33.51	20377248
219	Phosphorylation	INEHKVSSGSSLSLD HHHCCCCCCCCCEEE	45.76	22369663
221	Phosphorylation	EHKVSSGSSLSLDTS HCCCCCCCCCEEECC	30.01	22369663
222	Phosphorylation	HKVSSGSSLSLDTSE CCCCCCCCCEEECCC	26.04	20377248
224	Phosphorylation	VSSGSSLSLDTSENS CCCCCCCEEECCCCC	26.58	22369663
227	Phosphorylation	GSSLSLDTSENSDTK CCCCEEECCCCCCCC	43.14	19795423
228	Phosphorylation	SSLSLDTSENSDTKA CCCEEECCCCCCCCC	34.15	19795423
231	Phosphorylation	SLDTSENSDTKASQD EEECCCCCCCCCCCC	42.48	19795423
233	Phosphorylation	DTSENSDTKASQDKL ECCCCCCCCCCCCCC	28.47	19795423
236	Phosphorylation	ENSDTKASQDKLPVD CCCCCCCCCCCCCCC	40.23	22369663
254	Phosphorylation	APILRNVSAESSLSY CCCCCCCCCCCCHHC	29.84	22369663
257	Phosphorylation	LRNVSAESSLSYVKP CCCCCCCCCHHCCCE	35.97	22369663
258	Phosphorylation	RNVSAESSLSYVKPL CCCCCCCCHHCCCEE	16.91	22369663
260	Phosphorylation	VSAESSLSYVKPLIV CCCCCCHHCCCEEEE	29.81	22369663
261	Phosphorylation	SAESSLSYVKPLIVD CCCCCHHCCCEEEEC	20.13	22369663
276	Phosphorylation	NEEVNKASNGNLVQS HHHHHHHCCCCCCCC	47.05	20377248
283	Phosphorylation	SNGNLVQSDHLKEFS CCCCCCCCHHHHHHH	21.37	21440633
301	Phosphorylation	DDGDDKFSFSTSASG CCCCCCCEEECCCCC	24.83	22369663
303	Phosphorylation	GDDKFSFSTSASGKS CCCCCEEECCCCCCC	21.91	22369663
304	Phosphorylation	DDKFSFSTSASGKST CCCCEEECCCCCCCC	26.71	19795423
305	Phosphorylation	DKFSFSTSASGKSTK CCCEEECCCCCCCCC	21.17	22369663
307	Phosphorylation	FSFSTSASGKSTKSL CEEECCCCCCCCCCH	46.66	22369663
310	Phosphorylation	STSASGKSTKSLQQV ECCCCCCCCCCHHHH	44.59	19823750
311	Phosphorylation	TSASGKSTKSLQQVS CCCCCCCCCCHHHHC	28.30	19823750
313	Phosphorylation	ASGKSTKSLQQVSKD CCCCCCCCHHHHCCC	31.34	22369663
318	Phosphorylation	TKSLQQVSKDESSGF CCCHHHHCCCCCCCC	30.01	28889911
322	Phosphorylation	QQVSKDESSGFKAAH HHHCCCCCCCCEEEE	45.99	28889911
323	Phosphorylation	QVSKDESSGFKAAHF HHCCCCCCCCEEEEE	46.32	21551504
336	Phosphorylation	HFDFAYKSNEHLGSD EEEEEECCCCCCCCC	34.47	22369663
342	Phosphorylation	KSNEHLGSDGSIASA CCCCCCCCCCCCCCC	45.20	22369663
345	Phosphorylation	EHLGSDGSIASARKP CCCCCCCCCCCCCCC	21.70	22369663
348	Phosphorylation	GSDGSIASARKPLRI CCCCCCCCCCCCCEE	27.26	22369663
356	Phosphorylation	ARKPLRITNEIDSGS CCCCCEEECCCCCCC	21.99	23749301
361	Phosphorylation	RITNEIDSGSSNEDD EEECCCCCCCCCCCC	46.35	22369663
363	Phosphorylation	TNEIDSGSSNEDDDD ECCCCCCCCCCCCCC	33.66	22369663
364	Phosphorylation	NEIDSGSSNEDDDDG CCCCCCCCCCCCCCC	48.00	22369663
380	Phosphorylation	QEKGFVDSESKAFIN HHCCCCCCCHHHEEE	38.17	24961812
382	Phosphorylation	KGFVDSESKAFINYA CCCCCCCHHHEEEHH	32.98	24961812
388	Phosphorylation	ESKAFINYASDQGSS CHHHEEEHHHHCCCC	11.58	19779198
390	Phosphorylation	KAFINYASDQGSSIK HHEEEHHHHCCCCCC	21.80	22369663
394	Phosphorylation	NYASDQGSSIKNDVS EHHHHCCCCCCCCCC	24.21	22369663
395	Phosphorylation	YASDQGSSIKNDVST HHHHCCCCCCCCCCC	44.39	22369663
401	Phosphorylation	SSIKNDVSTQEPELP CCCCCCCCCCCCCCC	27.51	19779198
432	Phosphorylation	YLNSVNDTGSLTDKH EECCCCCCCCCCCCC	24.38	22369663
434	Phosphorylation	NSVNDTGSLTDKHSF CCCCCCCCCCCCCCC	30.13	22369663
436	Phosphorylation	VNDTGSLTDKHSFDT CCCCCCCCCCCCCCC	44.70	29734811
440	Phosphorylation	GSLTDKHSFDTASSG CCCCCCCCCCCCCCC	30.47	19795423
443	Phosphorylation	TDKHSFDTASSGEYD CCCCCCCCCCCCCCC	26.82	22369663
445	Phosphorylation	KHSFDTASSGEYDAK CCCCCCCCCCCCCCC	40.75	22369663
446	Phosphorylation	HSFDTASSGEYDAKS CCCCCCCCCCCCCCC	32.93	22369663
449	Phosphorylation	DTASSGEYDAKSNFS CCCCCCCCCCCCCCC	25.40	20377248
453	Phosphorylation	SGEYDAKSNFSSQSG CCCCCCCCCCCCCCC	44.84	22369663
456	Phosphorylation	YDAKSNFSSQSGLSI CCCCCCCCCCCCCEE	31.55	22369663
457	Phosphorylation	DAKSNFSSQSGLSIS CCCCCCCCCCCCEEC	24.99	20377248
459	Phosphorylation	KSNFSSQSGLSISKG CCCCCCCCCCEECCC	43.58	22369663
462	Phosphorylation	FSSQSGLSISKGSKS CCCCCCCEECCCCCC	28.48	20377248
464	Phosphorylation	SQSGLSISKGSKSTV CCCCCEECCCCCCEE	27.82	22369663
469	Phosphorylation	SISKGSKSTVLAALD EECCCCCCEEEEEEC	25.99	19823750
470	Phosphorylation	ISKGSKSTVLAALDS ECCCCCCEEEEEECC	24.23	19823750
477	Phosphorylation	TVLAALDSNGNTKSS EEEEEECCCCCCCCC	47.70	22369663
481	Phosphorylation	ALDSNGNTKSSNKTS EECCCCCCCCCCCCH	33.43	22369663
483	Phosphorylation	DSNGNTKSSNKTSEL CCCCCCCCCCCCHHH	36.78	22369663
484	Phosphorylation	SNGNTKSSNKTSELN CCCCCCCCCCCHHHH	43.85	22369663
488	Phosphorylation	TKSSNKTSELNSLNS CCCCCCCHHHHHHHH	41.52	19779198
492	Phosphorylation	NKTSELNSLNSISES CCCHHHHHHHHHCHH	41.37	28889911
536	Phosphorylation	SERSVKCSPLTSVVS CCCCCCCCCCCHHCC	19.75	23749301
540	Phosphorylation	VKCSPLTSVVSNKSE CCCCCCCHHCCCCCC	28.36	21551504
543	Phosphorylation	SPLTSVVSNKSEKSV CCCCHHCCCCCCCCC	36.06	28152593
546	Phosphorylation	TSVVSNKSEKSVPLV CHHCCCCCCCCCCCC	55.28	28152593
555	Phosphorylation	KSVPLVSSYVEELRL CCCCCCHHHHHHHHH	26.22	28889911
654	Phosphorylation	LLGKENETGSISKKE HHCCCCCCCCCCCCC	48.05	21440633
656	Phosphorylation	GKENETGSISKKEGT CCCCCCCCCCCCCCC	30.98	17330950
663	Phosphorylation	SISKKEGTDAEQAED CCCCCCCCCHHHHHH	32.88	28889911
671	Phosphorylation	DAEQAEDYLKDIPGD CHHHHHHHHHCCCCC	13.73	19779198
681	Phosphorylation	DIPGDEAYNSDDIMA CCCCCCCCCCCCCCH	17.10	22369663
683	Phosphorylation	PGDEAYNSDDIMAPL CCCCCCCCCCCCHHH	24.80	22369663
699	Phosphorylation	EKRGQNGSVDSVSRS HHCCCCCCCCCCCCC	30.24	25752575
702	Phosphorylation	GQNGSVDSVSRSNTV CCCCCCCCCCCCCCE	21.60	30377154
704	Phosphorylation	NGSVDSVSRSNTVVS CCCCCCCCCCCCEEE	33.66	30377154
708	Phosphorylation	DSVSRSNTVVSYYTR CCCCCCCCEEEEEEC	24.43	28889911
711	Phosphorylation	SRSNTVVSYYTRSQN CCCCCEEEEEECCCC	14.21	28889911
714	Phosphorylation	NTVVSYYTRSQNRMR CCEEEEEECCCCCCC	18.66	28889911
722	Phosphorylation	RSQNRMRSGTLDNDY CCCCCCCCCCCCCCC	27.13	22369663
724	Phosphorylation	QNRMRSGTLDNDYVN CCCCCCCCCCCCCCC	31.98	22369663
740	Phosphorylation	QKLPTHISLQDYRDA CCCCCCCCHHHHHCH	16.63	28889911
760	Phosphorylation	ISRQDSVSTTNSDVV CCCCCCCCCCCCCEE	33.20	22369663
761	Phosphorylation	SRQDSVSTTNSDVVD CCCCCCCCCCCCEEE	28.04	22369663
762	Phosphorylation	RQDSVSTTNSDVVDL CCCCCCCCCCCEEEE	25.81	22369663
764	Phosphorylation	DSVSTTNSDVVDLSY CCCCCCCCCEEEEHH	29.68	22369663
784	Phosphorylation	LRVANPDSDPE---- CEECCCCCCCC----	57.21	22890988

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YD239_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YD239_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YD239_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGD1_YEAST	RGD1	physical	18719252
SYIC_YEAST	ILS1	genetic	27708008
MAK5_YEAST	MAK5	genetic	27708008
UBC3_YEAST	CDC34	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
SWC4_YEAST	SWC4	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
FAL1_YEAST	FAL1	genetic	27708008
PDC2_YEAST	PDC2	genetic	27708008
RPB7_YEAST	RPB7	genetic	27708008
GPI19_YEAST	GPI19	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
RSC58_YEAST	RSC58	genetic	27708008
CH10_YEAST	HSP10	genetic	27708008
MED4_YEAST	MED4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-74; SER-164;SER-254; SER-276; SER-283; SER-313; SER-318; SER-342; SER-345;SER-390; SER-395; SER-492; SER-555; TYR-681; SER-683 AND SER-699, ANDMASS SPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-394; SER-395 ANDSER-683, AND MASS SPECTROMETRY.
PubMed: 17563356

"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477, AND MASSSPECTROMETRY.
PubMed: 17330950