VPS33_YEAST - dbPTM
VPS33_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS33_YEAST
UniProt AC P20795
Protein Name Vacuolar protein sorting-associated protein 33
Gene Name VPS33
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 691
Subcellular Localization Vacuole.
Protein Description Essential for vacuolar biogenesis, maturation and function. Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion..
Protein Sequence MNRFWNTKKFSLTNADGLCATLNEISQNDEVLVVQPSVLPVLNSLLTFQDLTQSTPVRKITLLDDQLSDDLPSALGSVPQMDLIFLIDVRTSLRLPPQLLDAAQKHNLSSLHIIYCRWKPSFQNTLEDTEQWQKDGFDLNSKKTHFPNVIESQLKELSNEYTLYPWDLLPFPQIDENVLLTHSLYNMENVNMYYPNLRSLQSATESILVDDMVNSLQSLIFETNSIITNVVSIGNLSKRCSHLLKKRIDEHQTENDLFIKGTLYGERTNCGLEMDLIILERNTDPITPLLTQLTYAGILDDLYEFNSGIKIKEKDMNFNYKEDKIWNDLKFLNFGSIGPQLNKLAKELQTQYDTRHKAESVHEIKEFVDSLGSLQQRQAFLKNHTTLSSDVLKVVETEEYGSFNKILELELEILMGNTLNNDIEDIILELQYQYEVDQKKILRLICLLSLCKNSLREKDYEYLRTFMIDSWGIEKCFQLESLAELGFFTSKTGKTDLHITTSKSTRLQKEYRYISQWFNTVPIEDEHAADKITNENDDFSEATFAYSGVVPLTMRLVQMLYDRSILFHNYSSQQPFILSREPRVSQTEDLIEQLYGDSHAIEESIWVPGTITKKINASIKSNNRRSIDGSNGTFHAAEDIALVVFLGGVTMGEIAIMKHLQKILGKKGINKRFIIIADGLINGTRIMNSIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
346UbiquitinationPQLNKLAKELQTQYD
HHHHHHHHHHHHHHH		70.1923749301
352PhosphorylationAKELQTQYDTRHKAE
HHHHHHHHHHHHHHH		23.7521440633
360PhosphorylationDTRHKAESVHEIKEF
HHHHHHHHHHHHHHH		33.3627717283
365UbiquitinationAESVHEIKEFVDSLG
HHHHHHHHHHHHHHH		41.9624961812
373PhosphorylationEFVDSLGSLQQRQAF
HHHHHHHHHHHHHHH		28.4428152593
618PhosphorylationITKKINASIKSNNRR
CHHHHCCCCCCCCCC		26.5121126336
620AcetylationKKINASIKSNNRRSI
HHHCCCCCCCCCCCC		44.6425381059
626PhosphorylationIKSNNRRSIDGSNGT
CCCCCCCCCCCCCCC		23.0728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS33_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS33_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS33_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS41_YEASTVPS41physical
10944212
VAM6_YEASTVAM6physical
10944212
PEP5_YEASTPEP5physical
10944212
VPS16_YEASTVPS16physical
10944212
PEP3_YEASTPEP3physical
10944212
VAM3_YEASTVAM3physical
11030345
VAM3_YEASTVAM3physical
11694574
PEP12_YEASTPEP12physical
15047864
YPT7_YEASTYPT7physical
12566429
VPS16_YEASTVPS16genetic
9362071
PEP7_YEASTPEP7genetic
15047864
PEP3_YEASTPEP3physical
16429126
PEP5_YEASTPEP5physical
16429126
VAM6_YEASTVAM6physical
16429126
VPS16_YEASTVPS16physical
16429126
VAM6_YEASTVAM6physical
15889152
PEP5_YEASTPEP5physical
15889152
PEP3_YEASTPEP3physical
15889152
VPS16_YEASTVPS16physical
15889152
VPS33_YEASTVPS33physical
15889152
VPS41_YEASTVPS41physical
15889152
VAM3_YEASTVAM3physical
15889152
VAM7_YEASTVAM7physical
15889152
NYV1_YEASTNYV1physical
15889152
VTI1_YEASTVTI1physical
15889152
YKT6_YEASTYKT6physical
15889152
VPS41_YEASTVPS41physical
16601699
VAM6_YEASTVAM6physical
16601699
PEP5_YEASTPEP5physical
16601699
PEP3_YEASTPEP3physical
16601699
VPS16_YEASTVPS16physical
16601699
PEP5_YEASTPEP5physical
18385512
VPS16_YEASTVPS16physical
18385512
PEP3_YEASTPEP3physical
18385512
VAM6_YEASTVAM6physical
18385512
VPS41_YEASTVPS41physical
18385512
YPT7_YEASTYPT7physical
19386605
DIP5_YEASTDIP5genetic
20093466
VAM6_YEASTVAM6physical
20453860
PEP3_YEASTPEP3physical
20453860
VAM3_YEASTVAM3physical
20453860
VPS16_YEASTVPS16physical
21325627
VPS8_YEASTVPS8physical
21325627
VAM6_YEASTVAM6physical
21325627
PEP5_YEASTPEP5physical
21325627
PEP3_YEASTPEP3physical
21325627
YPT52_YEASTYPT52physical
21325627
YPT1_YEASTYPT1physical
21325627
YPT53_YEASTYPT53physical
21325627
YPT6_YEASTYPT6physical
21325627
YPT7_YEASTYPT7physical
21325627
VPS16_YEASTVPS16physical
20604902
PEP5_YEASTPEP5physical
22940862
PYR1_YEASTURA2physical
22940862
VPS16_YEASTVPS16physical
22940862
VPS33_YEASTVPS33physical
22940862
VAM3_YEASTVAM3physical
23051737
VPS1_YEASTVPS1physical
23591871
VAM3_YEASTVAM3physical
23591871
SEC17_YEASTSEC17genetic
24837546
MDM34_YEASTMDM34genetic
27708008
DIP5_YEASTDIP5genetic
27708008
VPS41_YEASTVPS41physical
28925353
VAM3_YEASTVAM3physical
28925353
NYV1_YEASTNYV1physical
28925353
VTI1_YEASTVTI1physical
28925353
VAM7_YEASTVAM7physical
28925353
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS33_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373 AND SER-626, ANDMASS SPECTROMETRY.

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