dbPTM

VPS16_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VPS16_YEAST
UniProt AC	Q03308
Protein Name	Vacuolar protein sorting-associated protein 16
Gene Name	VPS16
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	798
Subcellular Localization	Cytoplasm. Vacuole.
Protein Description	Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. Required for growth at elevated temperatures. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion..
Protein Sequence	MKNPSFDWERLKDVFYRSRAIGELKWPTQYEEFKCALSLTVIAVEIQDFIQVYNYFGQLLGKINLQRIHEDIIKFEFDKDEKLILVTKSSIKIVKGWSPLTIESVPLQDPTIDTIWDYHNGIMLLAKSRDIYKLNGNEWELLYENKDKKYNLLTKNHWSCNDDSIILLDVDHVYQVSTSNGALLKLITDSSWHKVTISSRGFICLYNMKDNKLQIFRDPARILMEHNLDSTPDDICWCGNDTVACSFEDEIKLYGPDGLYVTFWYPFTVTNLRAEVDGLKVITTEKIYFLSRVQPQTSNIFRIGSTEPGAMLVDSFSLLEDHAPKAIEILKNFVLEKGVLDCIAAAIDEFEPKLQKMLLNAASYGKASLQYKSFDASIFVNACNTIKLLNCFRSFGIFLTVEEYRCISLKGVIDRLLKYHRYYECIQICKLANERFLLGYVFTEWAKDKIKGSPDMEDDELLDKIKSRLSVIDMTDTLQMVAVAKVAYLEGRFQLSRNLALLEKNEEARIEQLYNLDDDSIALKECIKVQNYSLTISLLIALSKKLTNSQLTKLLIIDMFNNPLYLYYMRMDKAYLYDFYRQTDRFIDLAHVLLQQGKEQQSLHSFLPQIKDLYSQVQNSEVVNNTIEQLQRQEKLWIYQESLGKRFAISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKISEKKLYHLKCKTLVEAKKFDELLQFAQSRKSPIGYMPFYTYLKSRGHMDKASPYVNMIPGLSYQEKKKLYVECRGFRDAIQLAGKEKDIPGLKEIYNIIPPNEPELKALANETMSRI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of VPS16_YEAST !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VPS16_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VPS16_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VPS16_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS41_YEAST	VPS41	physical	10944212
VAM6_YEAST	VAM6	physical	10944212
PEP5_YEAST	PEP5	physical	10944212
PEP3_YEAST	PEP3	physical	10944212
VPS33_YEAST	VPS33	physical	10944212
VPS33_YEAST	VPS33	physical	14662743
VAM6_YEAST	VAM6	physical	14662743
PEP7_YEAST	PEP7	genetic	11422941
VPS21_YEAST	VPS21	genetic	11422941
VPS45_YEAST	VPS45	genetic	11422941
PEP3_YEAST	PEP3	physical	16429126
PEP5_YEAST	PEP5	physical	16429126
VAM6_YEAST	VAM6	physical	16429126
VPS33_YEAST	VPS33	physical	16429126
VPS41_YEAST	VPS41	physical	16429126
VPS8_YEAST	VPS8	physical	16429126
SSB1_YEAST	SSB1	physical	19536198
YPT7_YEAST	YPT7	physical	19386605
ATPA_YEAST	ATP1	genetic	17322879
VPS33_YEAST	VPS33	physical	21325627
VAM6_YEAST	VAM6	physical	21325627
PEP5_YEAST	PEP5	physical	21325627
YPT52_YEAST	YPT52	physical	21325627
SEC4_YEAST	SEC4	physical	21325627
YPT52_YEAST	YPT52	genetic	20526336
YPT35_YEAST	YPT35	genetic	20526336
AIM3_YEAST	AIM3	genetic	20526336
VAM3_YEAST	VAM3	physical	22754631
NYV1_YEAST	NYV1	physical	22754631
VAM7_YEAST	VAM7	physical	22754631
TOR1_YEAST	TOR1	genetic	24514902

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VPS16_YEAST

Related Literatures of Post-Translational Modification