DCS2_YEAST - dbPTM
DCS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCS2_YEAST
UniProt AC Q12123
Protein Name Inactive diphosphatase DCS2
Gene Name DCS2 {ECO:0000312|SGD:S000005699}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 353
Subcellular Localization Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, P-body. Predominantly cytoplasmic. Localizes close to the perinuclear space before the diauxic growth shift. Recruited to the P-body after the post-diauxic growth shift. Colocalizes with the decapp
Protein Description Plays a role in the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Stress-induced regulatory protein that modulates the m7GpppX diphosphatase activity of DCS1..
Protein Sequence MGSQDLASLIGRFKYVRVLDSNPHTKVISLLGSIDGKDAVLTAEKTHFIFDETVRRPSQSGRSTPIFFHREIDEYSFLNGITDLKELTSNDIYYWGLSVLKQHILHNPTAKVNLIWPASQFHIKGYDQQDLHVVRETPDMYRNIVVPFIQEMCTSERMKWVNNILYEGAEDDRVVYKEYSSRNKEDGFVILPDMKWDGINIDSLYLVAIVYRDDIKSLRDLNPNHRDWLIRLNKKIKTIIPQHYDYNVNPDELRVFIHYQPSYYHFHVHIVNIRHPGVGEERGSGMTILLEDVIEALGFLGPEGYMKKTLTYVIGENHDLWKKGFKEEVEKQLKHDGIATSPEKGSGFNTNLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MGSQDLASLI
-----CCHHHHHHHH		21.1528889911
8PhosphorylationMGSQDLASLIGRFKY
CCHHHHHHHHHHCEE		28.0222369663
21PhosphorylationKYVRVLDSNPHTKVI
EEEEEECCCCCCCEE		48.3722369663
25PhosphorylationVLDSNPHTKVISLLG
EECCCCCCCEEEEEE		28.4122369663
42PhosphorylationDGKDAVLTAEKTHFI
CCCCCEEEEECEEEE		26.6022369663
46PhosphorylationAVLTAEKTHFIFDET
CEEEEECEEEEEECC		17.3322369663
53PhosphorylationTHFIFDETVRRPSQS
EEEEEECCCCCCCCC		22.5822369663
58PhosphorylationDETVRRPSQSGRSTP
ECCCCCCCCCCCCCC		34.8622369663
60PhosphorylationTVRRPSQSGRSTPIF
CCCCCCCCCCCCCEE		40.2822369663
63PhosphorylationRPSQSGRSTPIFFHR
CCCCCCCCCCEEEEC		41.9022369663
64PhosphorylationPSQSGRSTPIFFHRE
CCCCCCCCCEEEECC		21.0222369663
75PhosphorylationFHREIDEYSFLNGIT
EECCCHHHHCCCCCC		10.8524961812
166PhosphorylationKWVNNILYEGAEDDR
HHHHHHHHCCCCCCC		14.4419779198
340PhosphorylationLKHDGIATSPEKGSG
HCCCCCCCCCCCCCC		42.7822369663
341PhosphorylationKHDGIATSPEKGSGF
CCCCCCCCCCCCCCC		23.2622369663
346PhosphorylationATSPEKGSGFNTNLG
CCCCCCCCCCCCCCC		51.8119779198
350PhosphorylationEKGSGFNTNLG----
CCCCCCCCCCC----		29.5629136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NET1_YEASTNET1physical
16554755
DCPS_YEASTDCS1physical
16963086
HSP78_YEASTHSP78genetic
20093466
RTF1_YEASTRTF1genetic
20093466
GET1_YEASTGET1genetic
20093466
ASK10_YEASTASK10genetic
20093466
COPE_YEASTSEC28genetic
20093466
SNX4_YEASTSNX4genetic
20093466
FEN1_YEASTRAD27genetic
20093466
BRE2_YEASTBRE2genetic
20093466
VPS9_YEASTVPS9genetic
20093466
YPT7_YEASTYPT7genetic
20093466
YAR1_YEASTYAR1genetic
20093466
BRE1_YEASTBRE1genetic
27708008
GET1_YEASTGET1genetic
27708008
ASK10_YEASTASK10genetic
27708008
ICE2_YEASTICE2genetic
27708008
SNX4_YEASTSNX4genetic
27708008
VPS24_YEASTVPS24genetic
27708008
BRE2_YEASTBRE2genetic
27708008
VIP1_YEASTVIP1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
UBX2_YEASTUBX2genetic
27708008
VPS9_YEASTVPS9genetic
27708008
VPS27_YEASTVPS27genetic
27708008
PRM3_YEASTPRM3genetic
27708008
YAR1_YEASTYAR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-63; THR-64;THR-340 AND SER-341, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-64; THR-340 AND SER-341,AND MASS SPECTROMETRY.

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