MPD2_YEAST - dbPTM
MPD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPD2_YEAST
UniProt AC Q99316
Protein Name Protein disulfide isomerase MPD2
Gene Name MPD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 277
Subcellular Localization Endoplasmic reticulum .
Protein Description Non essential disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. Able to fold proteins by being directly oxidized by ERO1..
Protein Sequence MKLHGFLFSVLSTCVVILPALAYSEAVTMVKSIEQYFDICNRNDSYTMIKYYTSWCQHCKTLAPVYEELGELYAKKANKDDTPINFLEVNCEFFGPTLCTDLPGFPIIELVKPRTKPLVLPKLDWSSMKFHERLWQRIKTWFNNPKYQLDTSRVVRFEGSRNLKSLSNFIDTVRSKDTEERFIEHIFDDSRNCNEELRSQQLLCKAGKEYYSDTLSKLYGDVNGLEKERRRLEALIKQNGDDLSKEVKEKLKIIRLQLSLLSHIEDQLEDTSSHDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationKLHGFLFSVLSTCVV
CCHHHHHHHHHHHHH		25.0519823750
12PhosphorylationGFLFSVLSTCVVILP
HHHHHHHHHHHHHHH		20.0119823750
13PhosphorylationFLFSVLSTCVVILPA
HHHHHHHHHHHHHHH		12.7319823750
23PhosphorylationVILPALAYSEAVTMV
HHHHHHHHHHHHHHH		14.1119823750
24PhosphorylationILPALAYSEAVTMVK
HHHHHHHHHHHHHHH		17.3019823750
28PhosphorylationLAYSEAVTMVKSIEQ
HHHHHHHHHHHHHHH		24.2419823750
75AcetylationELGELYAKKANKDDT
HHHHHHHHHCCCCCC		38.5724489116
129AcetylationKLDWSSMKFHERLWQ
CCCHHHCHHHHHHHH		45.5824489116
146AcetylationKTWFNNPKYQLDTSR
HHHHHCCCCCCCCCC		47.9924489116
227AcetylationGDVNGLEKERRRLEA
CCCCHHHHHHHHHHH		62.6624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPD2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYRM_YEASTMSR1physical
10688190
ATG39_YEASTYLR312Cphysical
10688190
ERO1_YEASTERO1physical
10549279
SPT16_YEASTSPT16physical
16554755
CSK21_YEASTCKA1physical
16554755
YP117_YEASTYPR117Wphysical
16554755
YG5L_YEASTYGR266Wgenetic
16269340
RGP1_YEASTRGP1genetic
16269340
LST8_YEASTLST8genetic
16269340
RER1_YEASTRER1genetic
16269340
PFD2_YEASTGIM4genetic
19547744
KIN3_YEASTKIN3physical
22875988
VPS64_YEASTVPS64physical
22875988
IVY1_YEASTIVY1physical
22875988
MAD1_YEASTMAD1physical
22875988
KEL1_YEASTKEL1physical
22875988
DAD2_YEASTDAD2physical
22875988
NKP2_YEASTNKP2physical
22875988
END3_YEASTEND3physical
22875988
NUF2_YEASTNUF2physical
22875988
TEA1_YEASTTEA1physical
22875988
CTF19_YEASTCTF19physical
22875988
YP117_YEASTYPR117Wphysical
22875988
NOT3_YEASTNOT3physical
22875988
MOB2_YEASTMOB2genetic
27708008
ASPG1_YEASTASP1genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
ACA2_YEASTCST6genetic
27708008
LGE1_YEASTLGE1genetic
27708008
SUE1_YEASTSUE1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
KRR1_YEASTKRR1genetic
27708008
ACT_YEASTACT1genetic
27708008
COPD_YEASTRET2genetic
27708008
PRS8_YEASTRPT6genetic
27708008
XPO1_YEASTCRM1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
DNA2_YEASTDNA2genetic
27708008
CTF8_YEASTCTF8genetic
27708008
MOB1_YEASTMOB1genetic
27708008
MCM10_YEASTMCM10genetic
27708008
FIP1_YEASTFIP1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
SEC39_YEASTSEC39genetic
27708008
RSC9_YEASTRSC9genetic
27708008
VTI1_YEASTVTI1genetic
27708008
GAL10_YEASTGAL10genetic
27708008
ADPP_YEASTYSA1genetic
27708008
ICS2_YEASTICS2genetic
27708008
BUD31_YEASTBUD31genetic
27708008
ATG15_YEASTATG15genetic
27708008
YD179_YEASTYDR179W-Agenetic
27708008
GGA1_YEASTGGA1genetic
27708008
DOT1_YEASTDOT1genetic
27708008
SPS2_YEASTSPS2genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MSH4_YEASTMSH4genetic
27708008
HAC1_YEASTHAC1genetic
27708008
GEP7_YEASTGEP7genetic
27708008
YGI1_YEASTYGL081Wgenetic
27708008
CUE3_YEASTCUE3genetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
ADH4_YEASTADH4genetic
27708008
RME1_YEASTRME1genetic
27708008
CCH1_YEASTCCH1genetic
27708008
INM1_YEASTINM1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
SNL1_YEASTSNL1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
LPLA_YEASTAIM22genetic
27708008
MDM35_YEASTMDM35genetic
27708008
FABG_YEASTOAR1genetic
27708008
ELF1_YEASTELF1genetic
27708008
NNK1_YEASTNNK1genetic
27708008
ENT2_YEASTENT2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
PKR1_YEASTPKR1genetic
27708008
PET8_YEASTPET8genetic
27708008
OCA2_YEASTOCA2genetic
27708008
ATG3_YEASTATG3genetic
27708008
WHI5_YEASTWHI5genetic
27708008
PUR6_YEASTADE2genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
PMT3_YEASTPMT3genetic
27708008
PDE2_YEASTPDE2genetic
27708008
HAT1_YEASTHAT1genetic
27708008
COX10_YEASTCOX10genetic
27708008
RU2A_YEASTLEA1genetic
27708008
CHMU_YEASTARO7genetic
27708008
SPEE_YEASTSPE3genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPD2_YEAST

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Related Literatures of Post-Translational Modification

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