ASPG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASPG1_YEAST
• UniProt AC: P38986
• Protein Name: L-asparaginase 1
• Gene Name: ASP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MKSDSVEITTICPDVENSQFVVQSNCPETIPEILKSQNAAVNGSGIACQQRSLPRIKILGTGGTIASKAIDSSQTAGYHVDLTIQDLLDAIPDISKVCDIEYEQLCNVDSKDINEDILYKIYKGVSESLQAFDGIVITHGTDTLSETAFFIESTIDAGDVPIVFVGSMRPSTSVSADGPMNLYQAICIASNPKSRGRGVLVSLNDQISSGYYITKTNANSLDSFNVRQGYLGNFVNNEIHYYYPPVKPQGCHKFKLRVDGKHFKLPEVCILYAHQAFPPAIVNLVADKYDGIVLATMGAGSLPEEVNETCMKLSLPIVYSKRSMDGMVPIANVPKKGSKEDNLIASGYLSPEKSRILLQLCLAGNYTLEEIKHVFTGVYGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKSDSVEIT ------CCCCCEEEE	64.07	23749301
5	Phosphorylation	---MKSDSVEITTIC ---CCCCCEEEEEEC	28.83	21440633
36	Phosphorylation	TIPEILKSQNAAVNG CHHHHHHHCCCCCCC	25.81	21440633
61	Phosphorylation	PRIKILGTGGTIASK CCEEEEECCCCHHHH	29.06	21126336
111	Ubiquitination	QLCNVDSKDINEDIL HHCCCCCCCCCHHHH	59.15	23749301
120	Acetylation	INEDILYKIYKGVSE CCHHHHHHHHHCHHH	35.79	24489116
220	Phosphorylation	ITKTNANSLDSFNVR EEECCCCCCCCCCCC	31.01	22369663
223	Phosphorylation	TNANSLDSFNVRQGY CCCCCCCCCCCCCCE	24.82	22369663
230	Phosphorylation	SFNVRQGYLGNFVNN CCCCCCCEEHHHHCC	11.78	21551504
241	Phosphorylation	FVNNEIHYYYPPVKP HHCCEEEEECCCCCC	15.45	21551504
243	Phosphorylation	NNEIHYYYPPVKPQG CCEEEEECCCCCCCC	8.22	21551504
320	Phosphorylation	LSLPIVYSKRSMDGM HCCCEEEECCCCCCC	15.65	21440633
321	Ubiquitination	SLPIVYSKRSMDGMV CCCEEEECCCCCCCE	30.70	23749301
336	Acetylation	PIANVPKKGSKEDNL EEECCCCCCCCCCCE	63.45	24489116
346	Phosphorylation	KEDNLIASGYLSPEK CCCCEEECCCCCHHH	22.45	19823750
348	Phosphorylation	DNLIASGYLSPEKSR CCEEECCCCCHHHHH	11.08	19823750
350	Phosphorylation	LIASGYLSPEKSRIL EEECCCCCHHHHHHH	23.64	19795423
353	Ubiquitination	SGYLSPEKSRILLQL CCCCCHHHHHHHHHH	48.71	23749301
354	Phosphorylation	GYLSPEKSRILLQLC CCCCHHHHHHHHHHH	23.92	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASPG1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASPG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASPG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASPG1_YEAST	ASP1	physical	11283351
ASPG1_YEAST	ASP1	physical	18467557
ASPG1_YEAST	ASP1	physical	22615397
UBC9_HUMAN	UBE2I	physical	27107014
GMCL1_HUMAN	GMCL1	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND SER-350, ANDMASS SPECTROMETRY.
PubMed: 18407956