dbPTM

SFM1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SFM1_YEAST
UniProt AC	Q12314
Protein Name	Protein arginine N-methyltransferase SFM1 {ECO:0000305\|PubMed:22650761}
Gene Name	SFM1 {ECO:0000303\|PubMed:22650761}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	213
Subcellular Localization	Cytoplasm .
Protein Description	S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that monomethylates ribosomal protein S3 (RPS3) at 'Arg-146'..
Protein Sequence	MKYIIEHMEEGFSEWVILEYSQILREVGAENLILSSLPESTTEKDIPQRLLKLGLRWTTKDLKGINEDFKDLELLKDGRVCLLDPRATIDLQPEDATKFDYFVFGGILGDHPPRDRTKELKTAYPNLLISRRLGDKQMTTDTAIRTTQLIIKDRIAFEDIKFIDYPEFRFNKNEATEMPFRYVLDKEGKPILPEGMLDLIKKDSAQSLDDLLM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
20	Phosphorylation	SEWVILEYSQILREV CHHHHHHHHHHHHHH	28132839
44	Acetylation	LPESTTEKDIPQRLL CCCCCCCCCHHHHHH	24489116
52	Acetylation	DIPQRLLKLGLRWTT CHHHHHHHHCCCCCH	24489116
70	Acetylation	KGINEDFKDLELLKD CCCCCCCCCHHHHCC	24489116
76	Acetylation	FKDLELLKDGRVCLL CCCHHHHCCCCEEEE	24489116
136	Acetylation	ISRRLGDKQMTTDTA HEECCCCCCCCCCHH	24489116
139	Phosphorylation	RLGDKQMTTDTAIRT CCCCCCCCCCHHHHH	22369663
140	Phosphorylation	LGDKQMTTDTAIRTT CCCCCCCCCHHHHHH	22369663
142	Phosphorylation	DKQMTTDTAIRTTQL CCCCCCCHHHHHHHH	22369663
161	Ubiquitination	RIAFEDIKFIDYPEF CCCCCCCCCCCCCCC	23749301
172	Acetylation	YPEFRFNKNEATEMP CCCCCCCCCCCCCCC	24489116
202	Ubiquitination	GMLDLIKKDSAQSLD CHHHHHHHHCCCCHH	23749301
204	Phosphorylation	LDLIKKDSAQSLDDL HHHHHHHCCCCHHHH	22369663
207	Phosphorylation	IKKDSAQSLDDLLM- HHHHCCCCHHHHHC-	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SFM1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SFM1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SFM1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP71_YEAST	SSA1	physical	22940862
SFM1_YEAST	SFM1	physical	22940862
VPS8_YEAST	VPS8	genetic	27708008
YAJ9_YEAST	YAR029W	genetic	27708008
GID4_YEAST	VID24	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
RS10A_YEAST	RPS10A	genetic	27708008
YAJ8_YEAST	YAR028W	genetic	27708008
YBC9_YEAST	YBL029W	genetic	27708008
SHE1_YEAST	SHE1	genetic	27708008
YEL1_YEAST	YEL1	genetic	27708008
CHK1_YEAST	CHK1	genetic	27708008
STE50_YEAST	STE50	genetic	27708008
SAC3_YEAST	SAC3	genetic	27708008
MDM34_YEAST	MDM34	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
RL17B_YEAST	RPL17B	genetic	27708008
SWE1_YEAST	SWE1	genetic	27708008
ESL2_YEAST	ESL2	genetic	27708008
MMS22_YEAST	MMS22	genetic	27708008
VAC14_YEAST	VAC14	genetic	27708008
YO214_YEAST	SPR2	genetic	27708008
ELP3_YEAST	ELP3	genetic	27708008
CHMU_YEAST	ARO7	genetic	27708008
CSG2_YEAST	CSG2	genetic	29674565
TAF12_YEAST	TAF12	genetic	29674565
PUF6_YEAST	PUF6	genetic	29674565
SIC1_YEAST	SIC1	genetic	29674565
ELP1_YEAST	IKI3	genetic	29674565
ELP4_YEAST	ELP4	genetic	29674565
TGS1_YEAST	TGS1	genetic	29674565
CAK1_YEAST	CAK1	genetic	29674565

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SFM1_YEAST

Related Literatures of Post-Translational Modification