dbPTM

YMZ2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YMZ2_YEAST
UniProt AC	Q03177
Protein Name	WD repeat-containing protein YMR102C
Gene Name	YMR102C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	834
Subcellular Localization
Protein Description
Protein Sequence	MTNMAEDKTSISKVHSEFSNSSNTTGSEEESRSHQESFDGESSSGESKSKSKLNLEYSADIEPLKFRMTKTNNTNDKLKYSNNGNATDSFMRLKEHLQRGNTLNSNLRVNEFYPFNSIDTEQFENYLREPKYIKMLKRRKNLKQFRRLFLAQELMAYEGETVTSTSKSSEPTSKAIWSTKFSRDGKFMATGSKDGKIRIWKVIGSPVERAELDSSAESNKEARAKSMRIKQQVSSLNNPKEKQFLDSATEKYEEKEKLLNLYAPVFHPTPLRLYKEHVQDVLDINWSKNNFILSASMDKTVKLWHPDRKNSLKTFIHPDFVTCVEFHPTDDRFFISGCLDHKCRLWSILDDEVSFEYDCQDLITSVTLSPEEGKYTIIGTFNGYVHILMTRGLTPVSSFHVADRQTQEQNAHVMVTETDSKIRHGPRVTGLQAFRSQLDNSFRLVVTSNDSRIRIFDLEQRKLLEVLKGFHSGSSQHKAQLSIWHGQPIVVNSSDDHWVYGWRLKSSDRENDQDEPKRKPKGLARSGSLRSIFSKSMSRSSSQNNEEKPHHHLKLTNLLPLPHHSNDHYIKNTDYISFHAHNAPVTCVSIAPPETSKTLSLSNDVICELSLEFFQTSDSFDVLSRSNDDGIMSDVESSLGYNSKPGSISNASATSAIPDVVDAIGTILISTDNVGTIRVFRADMPSVIRKRVLLKLEEYNREVRRRFNSSDSLHSLSRSFNSRAKSNLAGQPAAAYTNTGKGYATGRGYSNICPKSSTSLKTLGSNAQPRTPRESMSSIFSNAHGPTTPTSAMNLPIRCNVCNGSRFEAFSGANDQQDRNYYCVDCGTVVNNFR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTNMAEDKT ------CCCCCCCCC	33.43	22369663
9	Phosphorylation	TNMAEDKTSISKVHS CCCCCCCCCHHHHHH	43.55	22369663
10	Phosphorylation	NMAEDKTSISKVHSE CCCCCCCCHHHHHHH	30.52	22369663
12	Phosphorylation	AEDKTSISKVHSEFS CCCCCCHHHHHHHHC	28.52	22369663
22	Phosphorylation	HSEFSNSSNTTGSEE HHHHCCCCCCCCCHH	42.31	22369663
24	Phosphorylation	EFSNSSNTTGSEEES HHCCCCCCCCCHHHH	34.19	22369663
25	Phosphorylation	FSNSSNTTGSEEESR HCCCCCCCCCHHHHH	42.85	22369663
27	Phosphorylation	NSSNTTGSEEESRSH CCCCCCCCHHHHHHC	39.48	22369663
31	Phosphorylation	TTGSEEESRSHQESF CCCCHHHHHHCCHHC	42.22	22369663
37	Phosphorylation	ESRSHQESFDGESSS HHHHCCHHCCCCCCC	23.28	28889911
42	Phosphorylation	QESFDGESSSGESKS CHHCCCCCCCCCCCC	35.02	17563356
43	Phosphorylation	ESFDGESSSGESKSK HHCCCCCCCCCCCCC	37.75	17563356
44	Phosphorylation	SFDGESSSGESKSKS HCCCCCCCCCCCCCC	56.72	29734811
69	Phosphorylation	EPLKFRMTKTNNTND CCEEEEEEECCCCCC	30.38	28889911
71	Phosphorylation	LKFRMTKTNNTNDKL EEEEEEECCCCCCCC	25.24	28889911
74	Phosphorylation	RMTKTNNTNDKLKYS EEEECCCCCCCCEEC	47.03	28889911
87	Phosphorylation	YSNNGNATDSFMRLK ECCCCCCCHHHHHHH	35.85	22369663
89	Phosphorylation	NNGNATDSFMRLKEH CCCCCCHHHHHHHHH	19.31	22369663
102	Phosphorylation	EHLQRGNTLNSNLRV HHHHCCCCCCCCCCC	30.09	30377154
105	Phosphorylation	QRGNTLNSNLRVNEF HCCCCCCCCCCCCEE	40.11	30377154
168	Phosphorylation	TVTSTSKSSEPTSKA CCEECCCCCCCCCCE	39.44	19779198
173	Phosphorylation	SKSSEPTSKAIWSTK CCCCCCCCCEEEEEE	30.70	19779198
178	Phosphorylation	PTSKAIWSTKFSRDG CCCCEEEEEEECCCC	18.66	19779198
182	Phosphorylation	AIWSTKFSRDGKFMA EEEEEEECCCCCEEE	30.90	19823750
190	Phosphorylation	RDGKFMATGSKDGKI CCCCEEEECCCCCCE	30.15	19823750
192	Phosphorylation	GKFMATGSKDGKIRI CCEEEECCCCCCEEE	24.18	19823750
205	Phosphorylation	RIWKVIGSPVERAEL EEEEEECCCCHHHHC	18.04	28889911
215	Phosphorylation	ERAELDSSAESNKEA HHHHCCCCCCCCHHH	35.40	30377154
218	Phosphorylation	ELDSSAESNKEARAK HCCCCCCCCHHHHHH	53.57	23749301
234	Phosphorylation	MRIKQQVSSLNNPKE HHHHHHHHCCCCHHH	25.44	30377154
235	Phosphorylation	RIKQQVSSLNNPKEK HHHHHHHCCCCHHHH	35.94	23749301
420	Phosphorylation	VMVTETDSKIRHGPR EEEECCCCCCCCCCC	37.08	27017623
447	Phosphorylation	NSFRLVVTSNDSRIR CCEEEEEECCCCCEE	17.84	22369663
448	Phosphorylation	SFRLVVTSNDSRIRI CEEEEEECCCCCEEE	27.34	22369663
451	Phosphorylation	LVVTSNDSRIRIFDL EEEECCCCCEEEEEH	33.58	22369663
526	Phosphorylation	KPKGLARSGSLRSIF CCCHHHCCCCHHHHH	27.42	20377248
528	Phosphorylation	KGLARSGSLRSIFSK CHHHCCCCHHHHHHH	23.12	22369663
531	Phosphorylation	ARSGSLRSIFSKSMS HCCCCHHHHHHHHCC	33.02	22369663
534	Phosphorylation	GSLRSIFSKSMSRSS CCHHHHHHHHCCCCC	23.35	21440633
536	Phosphorylation	LRSIFSKSMSRSSSQ HHHHHHHHCCCCCCC	22.31	27717283
538	Phosphorylation	SIFSKSMSRSSSQNN HHHHHHCCCCCCCCC	35.78	27717283
540	Phosphorylation	FSKSMSRSSSQNNEE HHHHCCCCCCCCCCC	27.34	28889911
541	Phosphorylation	SKSMSRSSSQNNEEK HHHCCCCCCCCCCCC	34.53	17287358
542	Phosphorylation	KSMSRSSSQNNEEKP HHCCCCCCCCCCCCC	37.87	17287358
633	Phosphorylation	SNDDGIMSDVESSLG CCCCCHHCHHHHHCC	36.26	27017623
638	Phosphorylation	IMSDVESSLGYNSKP HHCHHHHHCCCCCCC	16.59	28889911
699	Phosphorylation	VLLKLEEYNREVRRR HHHHHHHHCHHHHHH	15.33	24961812
709	Phosphorylation	EVRRRFNSSDSLHSL HHHHHCCCCHHHHHH	32.58	22369663
710	Phosphorylation	VRRRFNSSDSLHSLS HHHHCCCCHHHHHHH	32.12	22369663
712	Phosphorylation	RRFNSSDSLHSLSRS HHCCCCHHHHHHHHH	29.90	22369663
715	Phosphorylation	NSSDSLHSLSRSFNS CCCHHHHHHHHHHHH	33.08	22369663
717	Phosphorylation	SDSLHSLSRSFNSRA CHHHHHHHHHHHHHH	28.97	22369663
719	Phosphorylation	SLHSLSRSFNSRAKS HHHHHHHHHHHHHHH	25.96	24961812
722	Phosphorylation	SLSRSFNSRAKSNLA HHHHHHHHHHHHCCC	31.44	24961812
725	Ubiquitination	RSFNSRAKSNLAGQP HHHHHHHHHCCCCCC	38.47	23749301
726	Phosphorylation	SFNSRAKSNLAGQPA HHHHHHHHCCCCCCC	35.77	22369663
741	Ubiquitination	AAYTNTGKGYATGRG EEECCCCCCCCCCCC	46.86	23749301
756	Phosphorylation	YSNICPKSSTSLKTL CCCCCCCCCCCCCCC	24.80	21440633
757	Phosphorylation	SNICPKSSTSLKTLG CCCCCCCCCCCCCCC	28.30	21440633
758	Phosphorylation	NICPKSSTSLKTLGS CCCCCCCCCCCCCCC	45.21	21440633
759	Phosphorylation	ICPKSSTSLKTLGSN CCCCCCCCCCCCCCC	29.80	28152593
761	Acetylation	PKSSTSLKTLGSNAQ CCCCCCCCCCCCCCC	41.28	25381059
762	Phosphorylation	KSSTSLKTLGSNAQP CCCCCCCCCCCCCCC	41.46	22369663
765	Phosphorylation	TSLKTLGSNAQPRTP CCCCCCCCCCCCCCC	31.91	22369663
771	Phosphorylation	GSNAQPRTPRESMSS CCCCCCCCCHHHHHH	33.12	22369663
775	Phosphorylation	QPRTPRESMSSIFSN CCCCCHHHHHHHHCC	25.83	22369663
777	Phosphorylation	RTPRESMSSIFSNAH CCCHHHHHHHHCCCC	29.57	22369663
778	Phosphorylation	TPRESMSSIFSNAHG CCHHHHHHHHCCCCC	21.00	22369663
781	Phosphorylation	ESMSSIFSNAHGPTT HHHHHHHCCCCCCCC	31.28	22369663
787	Phosphorylation	FSNAHGPTTPTSAMN HCCCCCCCCCCCCCC	50.42	22369663
788	Phosphorylation	SNAHGPTTPTSAMNL CCCCCCCCCCCCCCC	27.92	22369663
790	Phosphorylation	AHGPTTPTSAMNLPI CCCCCCCCCCCCCCE	27.33	22369663
791	Phosphorylation	HGPTTPTSAMNLPIR CCCCCCCCCCCCCEE	27.07	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YMZ2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YMZ2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YMZ2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WRIP1_YEAST	MGS1	physical	10688190
SEC22_YEAST	SEC22	genetic	27708008
PRP6_YEAST	PRP6	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
DPOD_YEAST	POL3	genetic	27708008
GNA1_YEAST	GNA1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
CDC20_YEAST	CDC20	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
UTP13_YEAST	UTP13	genetic	27708008
HRP1_YEAST	HRP1	genetic	27708008
DYR_YEAST	DFR1	genetic	27708008
APC5_YEAST	APC5	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
YPK1_YEAST	YPK1	genetic	28774891

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YMZ2_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-43; SER-205;SER-709; THR-771 AND THR-788, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-43; SER-709;SER-712 AND THR-788, AND MASS SPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-528; SER-541 ANDSER-542, AND MASS SPECTROMETRY.	17287358 [Abstract]