VPS3_YEAST - dbPTM
VPS3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS3_YEAST
UniProt AC P23643
Protein Name Vacuolar protein sorting-associated protein 3
Gene Name VPS3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1011
Subcellular Localization Cytoplasm.
Protein Description Required for sorting and processing of soluble vacuolar proteins, integrity of vacuolar morphology, efficient segregation of vacuolar material into the bud during the cell cycle, acidification of the vacuolar lumen, and assembly of the vacuolar H(+)-ATPase..
Protein Sequence MVKKKTNNDKGKEVKENEGKLDIDSESSPHERENDKKKTEDDSLRATESEETNTHNANPNETVRADKFSQEESRPIEDSPHTDKNTAQESCQPSSAEDNVINTDITSLNEKTSTNDEQEKGLPLKISEGPFTISTLLDNVPSDLIYTCCEAYENHIFLGTTTGDLLHYFELERGNYMLVSQTKFDAESNSKIDKILLLPKVEGALILCDNELVLFILPEFAPRPNTTRLKGISDVVICNFSRSSKAYRIYAFHAEGVRLLKISADSLVLTKAFNFKLIDKACAHEETLMVSKLNSYELINLKSSQVIPLFRISETDEDLEPIITSFNEQSEFLVCSGGGSYDSGAMALVVNHHGDIIKGTIVLKNYPRNVIVEFPYIIAESAFQSVDIYSALPSEKSQLLQSITTSGSDLKISKSDNVFTNTNNSEEFKEKIFNKLRLEPLTHSDNKFRIERERAFVEESYEEKTSLIVYNNLGIHLLVPTPMVLRFTSCEESEIDNIEDQLKKLAKKDLTKFEHIEAKYLMSLLLFLMTLHYDHIEDEVMKKWCDFSDKVDIRILFYMFGWKVYSEIWCFHGLINIVERLKSLKLTNKCENILKMLLMMKNELKKKNKTGLLTNDFDDIMKTIDITLFKLRLEKKETITVDMFERESYDEIIREINLHDDKLPRIELLIEIYKEKGEYLKALNLLREAGDYISLVSFIEENLKKLPEDYIKERIADDLLLTLKQGDENTEECAIKKVLKILDMACINKNDFLNKIPAEETSLKVSFIEQLGVQNSNDSKFLFNYYLAKLREIINQSNIWSILGDFIKEYKDDFAYDKTDITNFIHIKLKHSLQCENFSKYYEKCENLKSENEKDDEFINFTFDEISKIDKEHILTLLFFPNELTNWVSSEELLKIYLSFNDFRSVEKYIGKQNLVAVMKQYLDISSLNYSVELVTNLLQRNFELLDDTDIQLKILETIPSVFPVQTISELLLKVLIKYQEKKEESNLRKCLLKNQISISDELSRNFDSQG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28PhosphorylationLDIDSESSPHEREND
CCCCCCCCCCCCCCC		26.6528889911
49PhosphorylationDSLRATESEETNTHN
HHCCCCCCCCCCCCC		36.0628889911
73PhosphorylationDKFSQEESRPIEDSP
CCCCCCCCCCCCCCC		42.4724961812
79PhosphorylationESRPIEDSPHTDKNT
CCCCCCCCCCCCCCC		13.0420377248
82PhosphorylationPIEDSPHTDKNTAQE
CCCCCCCCCCCCCHH		52.6424961812
106PhosphorylationNVINTDITSLNEKTS
CCCCCCCHHCCCCCC		29.9419779198
107PhosphorylationVINTDITSLNEKTST
CCCCCCHHCCCCCCC		29.5421440633
112PhosphorylationITSLNEKTSTNDEQE
CHHCCCCCCCCCHHH		34.3119779198
113PhosphorylationTSLNEKTSTNDEQEK
HHCCCCCCCCCHHHC		35.9619779198
610PhosphorylationELKKKNKTGLLTNDF
HHHHCCCCCCCCCCH		42.3227017623
662AcetylationEINLHDDKLPRIELL
HCCCCCCCCCHHHHH		67.4624489116
822PhosphorylationAYDKTDITNFIHIKL
CCCCCCCCCEEEEEE		27.2128889911
922PhosphorylationLVAVMKQYLDISSLN
HHHHHHHHCCHHHCC		10.7928889911
930PhosphorylationLDISSLNYSVELVTN
CCHHHCCHHHHHHHH		21.2728889911
931PhosphorylationDISSLNYSVELVTNL
CHHHCCHHHHHHHHH		14.1928889911
998PhosphorylationCLLKNQISISDELSR
HHHHCCCCCCHHHHH		13.2828889911
1004PhosphorylationISISDELSRNFDSQG
CCCCHHHHHHCCCCC		24.1128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS8_YEASTVPS8physical
17488625
PEP5_YEASTPEP5physical
17488625
PEP3_YEASTPEP3physical
17488625
VPS16_YEASTVPS16physical
17488625
VPS33_YEASTVPS33physical
17488625
VPS41_YEASTVPS41physical
17488625
HSP71_YEASTSSA1physical
19536198
VPS8_YEASTVPS8physical
19828734
PEP5_YEASTPEP5physical
19828734
MTC4_YEASTMTC4genetic
20093466
NBP2_YEASTNBP2genetic
20093466
SUR2_YEASTSUR2genetic
20093466
VAM7_YEASTVAM7genetic
20093466
MON1_YEASTMON1genetic
20093466
ERV14_YEASTERV14genetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
GPI7_YEASTLAS21genetic
20093466
CBF1_YEASTCBF1genetic
20093466
CSF1_YEASTCSF1genetic
20093466
CHS5_YEASTCHS5genetic
20093466
VAC14_YEASTVAC14genetic
20093466
GAS1_YEASTGAS1genetic
20093466
DFG16_YEASTDFG16genetic
20093466
HAL5_YEASTHAL5genetic
20206679
PIF1_YEASTPIF1genetic
19704012
ALG6_YEASTALG6genetic
19325107
ALG8_YEASTALG8genetic
19325107
GET1_YEASTGET1genetic
19325107
GET2_YEASTGET2genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
MSC1_YEASTMSC1genetic
19325107
UBX2_YEASTUBX2genetic
19325107
VPS1_YEASTVPS1genetic
19325107
VPS9_YEASTVPS9genetic
19325107
GET3_YEASTGET3genetic
19325107
TRS85_YEASTTRS85genetic
19325107
HRD3_YEASTHRD3genetic
19325107
ISW1_YEASTISW1genetic
19325107
KEX2_YEASTKEX2genetic
19325107
RER1_YEASTRER1genetic
19325107
GLU2A_YEASTROT2genetic
19325107
RUD3_YEASTRUD3genetic
19325107
SWC5_YEASTSWC5genetic
19325107
TLG2_YEASTTLG2genetic
19325107
UBC7_YEASTUBC7genetic
19325107
USA1_YEASTUSA1genetic
19325107
OS9_YEASTYOS9genetic
19325107
VPS8_YEASTVPS8physical
21325627
VPS21_YEASTVPS21physical
21325627
PEP5_YEASTPEP5physical
21325627
PEP3_YEASTPEP3physical
21325627
VPS16_YEASTVPS16physical
21325627
YPT52_YEASTYPT52physical
21325627
VPS41_YEASTVPS41physical
20604902
PEP5_YEASTPEP5physical
20604902
PEP3_YEASTPEP3physical
20604902
VPS16_YEASTVPS16physical
20604902
VPS33_YEASTVPS33physical
20604902
VAM6_YEASTVAM6genetic
24514902
VPS41_YEASTVPS41genetic
24514902
URE2_YEASTURE2genetic
24644271
PEP5_YEASTPEP5physical
23840658
VPS8_YEASTVPS8physical
23840658
PEP3_YEASTPEP3physical
23840658
VPS16_YEASTVPS16physical
23840658
VPS33_YEASTVPS33physical
23840658
MON1_YEASTMON1genetic
27708008
VPS35_YEASTVPS35genetic
27708008
VPS13_YEASTVPS13genetic
27708008
STU1_YEASTSTU1genetic
27708008
CDS1_YEASTCDS1genetic
27708008
MCM7_YEASTMCM7genetic
27708008
COPA_YEASTCOP1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
RIFK_YEASTFMN1genetic
27708008
COPB_YEASTSEC26genetic
27708008
TRS23_YEASTTRS23genetic
27708008
RSP5_YEASTRSP5genetic
27708008
YPT1_YEASTYPT1genetic
27708008
ACT_YEASTACT1genetic
27708008
COPD_YEASTRET2genetic
27708008
STT3_YEASTSTT3genetic
27708008
DUO1_YEASTDUO1genetic
27708008
NBP35_YEASTNBP35genetic
27708008
COPB2_YEASTSEC27genetic
27708008
GPI10_YEASTGPI10genetic
27708008
DAM1_YEASTDAM1genetic
27708008
XPO1_YEASTCRM1genetic
27708008
GPI16_YEASTGPI16genetic
27708008
CTF8_YEASTCTF8genetic
27708008
PAN1_YEASTPAN1genetic
27708008
OST1_YEASTOST1genetic
27708008
GWT1_YEASTGWT1genetic
27708008
HSP77_YEASTSSC1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
YKT6_YEASTYKT6genetic
27708008
SED5_YEASTSED5genetic
27708008
CDC91_YEASTGAB1genetic
27708008
NSE5_YEASTNSE5genetic
27708008
VTI1_YEASTVTI1genetic
27708008
TAF7_YEASTTAF7genetic
27708008
LCB1_YEASTLCB1genetic
27708008
CH10_YEASTHSP10genetic
27708008
SEC63_YEASTSEC63genetic
27708008
COPZ_YEASTRET3genetic
27708008
DPM1_YEASTDPM1genetic
27708008
MTC4_YEASTMTC4genetic
27708008
OST4_YEASTOST4genetic
27708008
ERV14_YEASTERV14genetic
27708008
GPI7_YEASTLAS21genetic
27708008
CSF1_YEASTCSF1genetic
27708008
CHS5_YEASTCHS5genetic
27708008
RIM13_YEASTRIM13genetic
27708008
GAS1_YEASTGAS1genetic
27708008
PEP7_YEASTPEP7genetic
23264632
VPS8_YEASTVPS8physical
23417307
PEP5_YEASTPEP5physical
23417307
PEP3_YEASTPEP3physical
23417307
VPS16_YEASTVPS16physical
23417307
VPS33_YEASTVPS33physical
23417307
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS3_YEAST

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Related Literatures of Post-Translational Modification

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