| UniProt ID | ALK2_YEAST | |
|---|---|---|
| UniProt AC | P32789 | |
| Protein Name | Serine/threonine-protein kinase Haspin homolog ALK2 | |
| Gene Name | ALK2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 676 | |
| Subcellular Localization | ||
| Protein Description | Serine/threonine haspin-like protein kinase involved in cell cycle regulation.. | |
| Protein Sequence | MNFDAVADQQMTDRRYFALEVAESDDADSSLNSSSMGSPAVDVGRKVYKITSHKGSAEDESQSFFTSSDSPTSKTRPVGKTIENDDYYGKRSSTGSSLKQLFNKININDTAHSSNKENVSQSVLSENKLLSPSKRLSKQGLTKVTNSKFRTPLRPISNQSTLSRDEPVKDFRSLKFRSGSDFKCWGDEKTSSHVHSSSVNSVNSFTSTTSSSKWKFWKNDNLLSRSLSSRSVNDQDPNFVQPKPTNSLQKKSSISSFHNSIFGGGKHTEKKRNSGFIMPDHQSTKELNHKHSSSNLSFRSLKHKTSHSSLNKLKVRRKGNTQELNHPIKKTCQISLPVPDQVSKDKIQLKLKNSTSLASLSSEVTPINTLDYNDSILQQILQLCDVKYILHDLREAQSLGLFTLNTRSVQLSHNFWQTYHSDMQTSLICKKVCLGALSDLTTSNLISLHELKSLRLIQGTSGVANLLQAYVVPSNQCENDQNLILYLFFKYQGTPLSRCSNIDYSQALSIFWQCSSILYVAESKFQLEHRNLTLDHILIDSKGNVTLIDMKCCRFLNIDNNKASYTRLDHHYFFQGRGTLQFEIYELMRSMLPQPISWATFEPRTNLLWLYHLSSSLLKMAKKAVVSGALNREENILIELTHLLDPARKHSKTIFKKELVIRTCGDLLSLKGEIMQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | AVADQQMTDRRYFAL HHCCHHHCCCCEEEE | 23.24 | 30377154 | |
| 24 | Phosphorylation | FALEVAESDDADSSL EEEEECCCCCCCCCC | 30.93 | 28889911 | |
| 51 | Phosphorylation | GRKVYKITSHKGSAE CCEEEEEECCCCCCC | 22.19 | 29688323 | |
| 52 | Phosphorylation | RKVYKITSHKGSAED CEEEEEECCCCCCCC | 27.03 | 27017623 | |
| 56 | Phosphorylation | KITSHKGSAEDESQS EEECCCCCCCCCCCC | 33.03 | 27017623 | |
| 61 | Phosphorylation | KGSAEDESQSFFTSS CCCCCCCCCCCCCCC | 43.37 | 29688323 | |
| 63 | Phosphorylation | SAEDESQSFFTSSDS CCCCCCCCCCCCCCC | 31.44 | 27017623 | |
| 66 | Phosphorylation | DESQSFFTSSDSPTS CCCCCCCCCCCCCCC | 25.88 | 19823750 | |
| 67 | Phosphorylation | ESQSFFTSSDSPTSK CCCCCCCCCCCCCCC | 27.30 | 19823750 | |
| 68 | Phosphorylation | SQSFFTSSDSPTSKT CCCCCCCCCCCCCCC | 38.76 | 19823750 | |
| 70 | Phosphorylation | SFFTSSDSPTSKTRP CCCCCCCCCCCCCCC | 31.83 | 23749301 | |
| 72 | Phosphorylation | FTSSDSPTSKTRPVG CCCCCCCCCCCCCCC | 46.97 | 19823750 | |
| 73 | Phosphorylation | TSSDSPTSKTRPVGK CCCCCCCCCCCCCCE | 35.10 | 19823750 | |
| 131 | Phosphorylation | LSENKLLSPSKRLSK HCCCCCCCHHHHHHH | 37.25 | 21551504 | |
| 173 | Phosphorylation | EPVKDFRSLKFRSGS CCCCCHHHCCCCCCC | 35.59 | 27017623 | |
| 198 | Phosphorylation | SSHVHSSSVNSVNSF CCCCCCCCCCCCCCC | 28.47 | 21551504 | |
| 201 | Phosphorylation | VHSSSVNSVNSFTST CCCCCCCCCCCCCCC | 22.11 | 21551504 | |
| 224 | Phosphorylation | WKNDNLLSRSLSSRS ECCCCHHHHHHCCCC | 24.00 | 28889911 | |
| 226 | Phosphorylation | NDNLLSRSLSSRSVN CCCHHHHHHCCCCCC | 29.27 | 21551504 | |
| 228 | Phosphorylation | NLLSRSLSSRSVNDQ CHHHHHHCCCCCCCC | 25.59 | 21440633 | |
| 229 | Phosphorylation | LLSRSLSSRSVNDQD HHHHHHCCCCCCCCC | 33.59 | 27017623 | |
| 231 | Phosphorylation | SRSLSSRSVNDQDPN HHHHCCCCCCCCCCC | 27.50 | 23749301 | |
| 252 | Phosphorylation | TNSLQKKSSISSFHN CCCCCCCHHHHHHCH | 39.68 | 19823750 | |
| 253 | Phosphorylation | NSLQKKSSISSFHNS CCCCCCHHHHHHCHH | 35.06 | 20377248 | |
| 255 | Phosphorylation | LQKKSSISSFHNSIF CCCCHHHHHHCHHHC | 28.97 | 24961812 | |
| 256 | Phosphorylation | QKKSSISSFHNSIFG CCCHHHHHHCHHHCC | 28.93 | 21440633 | |
| 260 | Phosphorylation | SISSFHNSIFGGGKH HHHHHCHHHCCCCCC | 15.66 | 19823750 | |
| 292 | Phosphorylation | KELNHKHSSSNLSFR HHCCCCCCCCCCCHH | 40.02 | 28889911 | |
| 297 | Phosphorylation | KHSSSNLSFRSLKHK CCCCCCCCHHHHCCC | 23.90 | 28889911 | |
| 305 | Phosphorylation | FRSLKHKTSHSSLNK HHHHCCCCCCHHHHH | 31.24 | 28889911 | |
| 306 | Phosphorylation | RSLKHKTSHSSLNKL HHHCCCCCCHHHHHC | 26.61 | 28889911 | |
| 308 | Phosphorylation | LKHKTSHSSLNKLKV HCCCCCCHHHHHCCC | 35.97 | 30377154 | |
| 309 | Phosphorylation | KHKTSHSSLNKLKVR CCCCCCHHHHHCCCE | 30.45 | 28889911 | |
| 331 | Phosphorylation | LNHPIKKTCQISLPV CCCCCCCCEEEECCC | 12.49 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ALK2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ALK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ALK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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