MTD1_YEAST - dbPTM
MTD1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTD1_YEAST
UniProt AC Q02046
Protein Name Methylenetetrahydrofolate dehydrogenase [NAD(+)]
Gene Name MTD1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 320
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis..
Protein Sequence MSKPGRTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMGFRYDLRVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEGLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIVINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKKCSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFSDDVKEKASLYVPMTGKVTIAMLLRNMLRLVRNVELSKEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
118AcetylationQQVVCKEKDVEGLNH
HHHHHCCCCCCCCCH		53.2024489116
145AcetylationLDKENRLKSILPCTP
ECHHCCHHHHCCCCH		32.0124489116
178UbiquitinationEGNRLYGKKCIVINR
CCCCCCCCEEEEECH		30.8022817900
179UbiquitinationGNRLYGKKCIVINRS
CCCCCCCEEEEECHH		25.4922817900
214UbiquitinationVDVNNIQKFTRGESL
EECCCCEEECCCCCC		44.9322817900
240AcetylationEYSEDLLKKCSLDSD
HCCHHHHHHCCCCCC		60.0624489116
295PhosphorylationASLYVPMTGKVTIAM
HEEECCCCCHHHHHH		27.9927017623
299PhosphorylationVPMTGKVTIAMLLRN
CCCCCHHHHHHHHHH		13.4022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTD1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTD1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTD1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTD1_YEASTMTD1physical
18467557
MTD1_YEASTMTD1physical
10933503
HPRT_YEASTHPT1genetic
21623372
KICH_YEASTCKI1genetic
21623372
ATF2_YEASTATF2genetic
21623372
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SMC3_YEASTSMC3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
SEC65_YEASTSEC65genetic
27708008
SYA_YEASTALA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTD1_YEAST

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Related Literatures of Post-Translational Modification

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