THO1_YEAST - dbPTM
THO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THO1_YEAST
UniProt AC P40040
Protein Name Protein THO1
Gene Name THO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 218
Subcellular Localization
Protein Description Unknown; suppressor of the transcriptional defect of HPR1 by overexpression..
Protein Sequence MADYSSLTVVQLKDLLTKRNLSVGGLKNELVQRLIKDDEESKGESEVSPQEQNQEQGSEPAAIEEPASQNITEKKEVSSEPKETNEPKEENKDVQKPSDGPSATASENEQAAASTAAPALSPEEIKAKALDLLNKKLHRANKFGQDQADIDSLQRQINRVEKFGVDLNSKLAEELGLVSRKNEPESGNNGKFKNRNKNANNRSRVSKNRRGNRSGYRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationLLTKRNLSVGGLKNE
HHHHCCCCCCCHHHH		23.4319823750
41PhosphorylationLIKDDEESKGESEVS
HHHCCCHHCCCCCCC		43.8629136822
45PhosphorylationDEESKGESEVSPQEQ
CCHHCCCCCCCHHHH		52.5522369663
48PhosphorylationSKGESEVSPQEQNQE
HCCCCCCCHHHHHHH		19.4722369663
58PhosphorylationEQNQEQGSEPAAIEE
HHHHHCCCCCCHHCC		39.8522369663
68PhosphorylationAAIEEPASQNITEKK
CHHCCCHHCCCCCHH		34.1822369663
72PhosphorylationEPASQNITEKKEVSS
CCHHCCCCCHHCCCC		49.6722369663
78PhosphorylationITEKKEVSSEPKETN
CCCHHCCCCCCCCCC		30.0324909858
79PhosphorylationTEKKEVSSEPKETNE
CCHHCCCCCCCCCCC		64.1924909858
98PhosphorylationNKDVQKPSDGPSATA
CCCCCCCCCCCCCCC		63.3320377248
102PhosphorylationQKPSDGPSATASENE
CCCCCCCCCCCCHHH		43.7220377248
104PhosphorylationPSDGPSATASENEQA
CCCCCCCCCCHHHHH		34.7522369663
106PhosphorylationDGPSATASENEQAAA
CCCCCCCCHHHHHHH		36.2820377248
114PhosphorylationENEQAAASTAAPALS
HHHHHHHHCCCCCCC		17.5320377248
115PhosphorylationNEQAAASTAAPALSP
HHHHHHHCCCCCCCH		23.3220377248
121PhosphorylationSTAAPALSPEEIKAK
HCCCCCCCHHHHHHH		32.1622369663
142UbiquitinationKKLHRANKFGQDQAD
HHHHHHHHHCCCHHH		50.3023749301
142AcetylationKKLHRANKFGQDQAD
HHHHHHHHHCCCHHH		50.3024489116
162AcetylationRQINRVEKFGVDLNS
HHHHHHHHHCCCHHH		44.5624489116
170AcetylationFGVDLNSKLAEELGL
HCCCHHHHHHHHHCC		51.1225381059
179PhosphorylationAEELGLVSRKNEPES
HHHHCCCCCCCCCCC		42.4530377154
191AcetylationPESGNNGKFKNRNKN
CCCCCCCCCCCCCCC		56.1225381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THO1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THO1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FBRL_YEASTNOP1physical
16554755
MAM33_YEASTMAM33physical
16554755
NAP1_YEASTNAP1physical
16554755
RRP5_YEASTRRP5physical
16554755
IMB3_YEASTPSE1physical
16554755
SUB2_YEASTSUB2physical
11283351
THO1_YEASTTHO1physical
18467557
SUB2_YEASTSUB2physical
18719252
POP7_YEASTPOP7genetic
27708008
PRP9_YEASTPRP9genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
KOG1_YEASTKOG1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
IF2A_YEASTSUI2genetic
27708008
HSP77_YEASTSSC1genetic
27708008
ARP3_YEASTARP3genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CDC25_YEASTCDC25genetic
27708008
NOP2_YEASTNOP2genetic
27708008
TRM6_YEASTGCD10genetic
27708008
NOG2_YEASTNOG2genetic
27708008
SGT1_YEASTSGT1genetic
27708008
IF6_YEASTTIF6genetic
27708008
CCL1_YEASTCCL1genetic
27708008
SRP54_YEASTSRP54genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THO1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-102, AND MASSSPECTROMETRY.

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