| UniProt ID | CCL1_YEAST | |
|---|---|---|
| UniProt AC | P37366 | |
| Protein Name | Cyclin CCL1 | |
| Gene Name | CCL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 393 | |
| Subcellular Localization | ||
| Protein Description | Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.. | |
| Protein Sequence | MTDIQLNGKSTLDTPSATMSAKEKEAKLKSADENNKPPNYKRISDDDLYRHSSQYRMWSYTKDQLQEKRVDTNARAIAYIEENLLKFREAHNLTEEEIKVLEAKAIPLTMEEELDLVNFYAKKVQVIAQHLNLPTEVVATAISFFRRFFLENSVMQIDPKSIVHTTIFLACKSENYFISVDSFAQKAKSTRDSVLKFEFKLLESLKFSLLNHHPYKPLHGFFLDIQNVLYGKVDLNYMGQIYDRCKKRITAALLTDVVYFYTPPQITLATLLIEDEALVTRYLETKFPSREGSQESVPGNEKEEPQNDASTTEKNKEKSTESEEYSIDSAKLLTIIRECKSIIEDCKPPSTEEAKKIAAKNYYCQNPSTLIQKLKRKLNGEDTSSTVEKKQKT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | TLDTPSATMSAKEKE CCCCCCCCCCHHHHH | 18.92 | 27017623 | |
| 44 | Phosphorylation | PPNYKRISDDDLYRH CCCCCCCCHHHHHHH | 38.73 | 27017623 | |
| 99 | Acetylation | NLTEEEIKVLEAKAI CCCHHHHHHHHHHCC | 44.01 | 24489116 | |
| 193 | Phosphorylation | KAKSTRDSVLKFEFK HHHHCHHHHHHHHHH | 26.51 | 28889911 | |
| 293 | Phosphorylation | KFPSREGSQESVPGN CCCCCCCCCCCCCCC | 26.48 | 23749301 | |
| 296 | Phosphorylation | SREGSQESVPGNEKE CCCCCCCCCCCCCCC | 26.44 | 23749301 | |
| 319 | Phosphorylation | TEKNKEKSTESEEYS CHHHHHHCCCCCCCC | 38.20 | 28889911 | |
| 389 | Acetylation | DTSSTVEKKQKT--- CCCCHHHHHHCC--- | 57.05 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCL1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCL1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCL1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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