SMK1_YEAST - dbPTM
SMK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SMK1_YEAST
UniProt AC P41808
Protein Name Sporulation-specific mitogen-activated protein kinase SMK1
Gene Name SMK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 388
Subcellular Localization
Protein Description Required for spore wall assembly. Required for proper deposition of the two outer layers of the spore wall, the chitosan and dityrosine layers. Negatively regulates GSC2, an alternate catalytic subunit of the 1,3-beta-glucan synthase (GS). Participates in a developmentally regulated signal transduction pathway that coordinates cytodifferentiation events with the transcriptional program..
Protein Sequence MNCTLTDNTRAINVASNLGAPQQRTIFAKERISIPGYYEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYDGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPFLNEVRKPDDEPVCLQGPFDFTYESELNSMSKLRDYLVEEVKNFKTDLSSSSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster

Oops, there are no PTM records of SMK1_YEAST !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SMK1_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
207TPhosphorylation

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Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SMK1_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAOM_YEASTMAE1physical
11805837
QCR1_YEASTCOR1physical
11805837
BUD7_YEASTBUD7physical
11805837
SLT2_YEASTSLT2physical
11805837
GAL7_YEASTGAL7physical
11805837
STI1_YEASTSTI1physical
11805837
PSB1_YEASTPRE3physical
11805837
QCR2_YEASTQCR2physical
11805837
RIR2_YEASTRNR2physical
11805837
CAK1_YEASTCAK1physical
10688190
CAK1_YEASTCAK1genetic
9135146
RSC1_YEASTRSC1genetic
15302824
RSC2_YEASTRSC2genetic
15302824
FKS2_YEASTGSC2physical
16116083
WWM1_YEASTWWM1physical
11283351
KCS1_YEASTKCS1genetic
19269370
CAK1_YEASTCAK1genetic
19269370
ADK_YEASTADO1genetic
19269370
MSG5_YEASTMSG5genetic
19269370
IME2_YEASTIME2genetic
19087957
CDC25_YEASTCDC25genetic
19087957
CYAA_YEASTCYR1genetic
19087957
MDS3_YEASTMDS3genetic
19087957
PMD1_YEASTPMD1genetic
19087957
NDH2_YEASTNDE2physical
20489023
SA185_YEASTSAP185physical
20489023
3HAO_YEASTBNA1physical
21460040
HSV2_YEASTHSV2physical
21460040
TR112_YEASTTRM112physical
21460040
UBA1_YEASTUBA1physical
21460040
PP4C_YEASTPPH3genetic
21127252
RAD52_YEASTRAD52genetic
21127252
CTK3_YEASTCTK3genetic
21127252
CG11_YEASTCLN1genetic
21127252
SMK1_YEASTSMK1physical
23207907
PAU21_YEASTPAU21genetic
22282571
PAU22_YEASTPAU21genetic
22282571
FKH2_YEASTFKH2genetic
22282571
MED3_YEASTPGD1genetic
22282571
PP2C4_YEASTPTC4genetic
22282571
RL19A_YEASTRPL19Bgenetic
22282571
RL19B_YEASTRPL19Bgenetic
22282571
AMN1_YEASTAMN1genetic
22282571
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
AMN1_YEASTAMN1genetic
27708008

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SMK1_YEAST

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Related Literatures of Post-Translational Modification

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