| UniProt ID | SPT21_YEAST | |
|---|---|---|
| UniProt AC | P35209 | |
| Protein Name | Protein SPT21 | |
| Gene Name | SPT21 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 758 | |
| Subcellular Localization | ||
| Protein Description | Required for normal transcription at a number of loci in yeast.. | |
| Protein Sequence | MSELSQMTLKILYTLDNGSNGSYLARSRAPKQVRVANIPSPFPTDSNEQTELRIGAIHLKTILHEIYLNSPEVLDHDTLKDGYDYNLYYRDICEVDEPLVSLGLLSGLRKKFHKNSPYQYTENNIGEEESEERDEVTEEEYEDESFIVTGRVCSNVSALLRRSYSNISNKKGRVVNNQIPEETLEVKLRFTKVITNLRTSGNNTTNSRISCLQMPSSLPSATLPFTPKSQSLFKTNQIKNSRNARTTITINNTNSGTVGRRQTNPMPAPKAVRTQSLPIWNLKPNIANTGFPRNSIAHKIYLADRKTEANQQNNQHQNIAYEINTLQNDNTIQRTKIDDSVSKRFDFMLNKRKSTKKVSPGIATIAKKPASININPKQPPKTSGEKKANDKQTIVKVKNSNSKNSAKSTQAGCRRSSVIEHLNDHDDSILSDILSEPGIEGQKLQQKQKGRKISLTSENDKENIPPQSITSKENKLEGDLDFNAEFPMSDFSDVVFKDEMGWFSNFNCNFFESPTSASASQLNQQNLKPSITLNDPNTCNTIALENEDVSELETAQNNKISLPSDVDKTSPIDSLSIPLIELTHSSSTTNMQRISIKEGSTLNITDSNNATPCDNDIKDRKASVIDSDNTKPQAGLINFSTPADQPASDNNVTASKKLTSMLETQQSKRSHEEVLDEEEEEEALKKQKAIPSSPCGMFNYHQPMELSEDIVEEEQGHNIGDDNESDKTNDLFSTFIHSGIRVSQVVTSPIGEFQSIKH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 165 | Phosphorylation | ALLRRSYSNISNKKG HHHHHHHHCCCCCCC | 29.00 | 23749301 | |
| 274 | Phosphorylation | PAPKAVRTQSLPIWN CCCCCCCCCCCCEEE | 18.86 | 21440633 | |
| 276 | Phosphorylation | PKAVRTQSLPIWNLK CCCCCCCCCCEEECC | 35.18 | 25752575 | |
| 359 | Phosphorylation | RKSTKKVSPGIATIA CCCCCCCCCCCCHHC | 26.70 | 21440633 | |
| 371 | Phosphorylation | TIAKKPASININPKQ HHCCCCCCCCCCCCC | 25.37 | 25704821 | |
| 402 | Phosphorylation | VKVKNSNSKNSAKST EEEECCCCCCCCHHH | 32.79 | 19779198 | |
| 454 | Phosphorylation | KQKGRKISLTSENDK HHCCCCCCCCCCCCC | 28.73 | 17287358 | |
| 570 | Phosphorylation | PSDVDKTSPIDSLSI CCCCCCCCCCCCCCC | 26.12 | 21440633 | |
| 595 | Phosphorylation | TTNMQRISIKEGSTL CCCCEEEEEECCCEE | 29.78 | 21440633 | |
| 600 | Phosphorylation | RISIKEGSTLNITDS EEEEECCCEEEECCC | 30.71 | 28889911 | |
| 601 | Phosphorylation | ISIKEGSTLNITDSN EEEECCCEEEECCCC | 34.38 | 27017623 | |
| 605 | Phosphorylation | EGSTLNITDSNNATP CCCEEEECCCCCCCC | 32.09 | 27017623 | |
| 607 | Phosphorylation | STLNITDSNNATPCD CEEEECCCCCCCCCC | 24.27 | 23749301 | |
| 611 | Phosphorylation | ITDSNNATPCDNDIK ECCCCCCCCCCCCCC | 26.94 | 23749301 | |
| 623 | Phosphorylation | DIKDRKASVIDSDNT CCCCCCCCEECCCCC | 23.73 | 23749301 | |
| 627 | Phosphorylation | RKASVIDSDNTKPQA CCCCEECCCCCCCCC | 22.95 | 28889911 | |
| 630 | Phosphorylation | SVIDSDNTKPQAGLI CEECCCCCCCCCCEE | 49.44 | 27717283 | |
| 693 | Phosphorylation | KQKAIPSSPCGMFNY HCCCCCCCCCCCCCC | 20.89 | 28889911 | |
| 743 | Phosphorylation | IHSGIRVSQVVTSPI HHHCCCCEEEEECCC | 13.86 | 28889911 | |
| 747 | Phosphorylation | IRVSQVVTSPIGEFQ CCCEEEEECCCCCCC | 29.90 | 19684113 | |
| 748 | Phosphorylation | RVSQVVTSPIGEFQS CCEEEEECCCCCCCC | 11.69 | 25752575 | |
| 755 | Phosphorylation | SPIGEFQSIKH---- CCCCCCCCCCC---- | 38.64 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPT21_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPT21_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPT21_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276 AND SER-693, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, AND MASSSPECTROMETRY. | |
