PDR1_YEAST - dbPTM
PDR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDR1_YEAST
UniProt AC P12383
Protein Name Transcription factor PDR1
Gene Name PDR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1068
Subcellular Localization Nucleus.
Protein Description Positive regulator of proteins involved in permeability. PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5..
Protein Sequence MRGLTPKNGVHIETGPDTESSADSSNFSTGFSGKIRKPRSKVSKACDNCRKRKIKCNGKFPCASCEIYSCECTFSTRQGGARIKNLHKTSLEGTTVQVKEETDSSSTSFSNPQRCTDGPCAVEQPTKFFENFKLGGRSSGDNSGSDGKNDDDVNRNGFYEDDSESQATLTSLQTTLKNLKEMAHLGTHVTSAIESIELQISDLLKRWEPKVRTKELATTKFYPNKSIETQLMKNKYCDVVHLTRYAAWSNNKKDQDTSSQPLIDEIFGLYSPFQFLSLQGIGKCFQNYRSKSKCEIFPRTAKETIYIMLRFFDVCFHHINQGCVSIANPLENYLQKMNLLPSTPSSISSAGSPNTAHTKSHVALVINHLPQPFVRNITGISNSELLSEMNNDISMFGILLKMLDMHKNSYQNFLMEITSNPSVAKNTQSIDVLQEFIHYCQAGEALIALCYSYYNSTLYNYVDFTCDITHLEQLLYFLDLLFWLSEIYGFEKVLNVAVHFVSRVGLSRWEFYVGLDENFAERRRNLWWKAFYFEKTLASKLGYPSNIDDSKINCLLPKNFRDVGFLDNRDFIENVHLVRRSEAFDNMCISDLKYYGELAVLQIVSHFSSSVLFNEKFTSIRNTSKPSVVREKLLFEVLEIFNETEMKYDAIKEQTGKLFDIAFSKDSTELKVSREDKIMASKFVLFYEHHFCRMVNESDNIVARLCVHRRPSILIENLKIYLHKIYKSWTDMNKILLDFDNDYSVYRSFAHYSISCIILVSQAFSVAEFIKVNDVVNMIRVFKRFLDIKIFSENETNEHVFNSQSFKDYTRAFSFLTIVTRIMLLAYGESSSTNLDVISKYIDENAPDLKGIIELVLDTNSCAYRFLLEPVQKSGFHLTVSQMLKNRKFQEPLMSNEDNKQMKHNSGKNLNPDLPSLKTGTSCLLNGIESPQLPFNGRSAPSPVRNNSLPEFAQLPSFRSLSVSDMINPDYAQPTNGQNNTQVQSNKPINAQQQIPTSVQVPFMNTNEINNNNNNNNNNKNNINNINNNNSNNFSATSFNLGTLDEFVNNGDLEDLYSILWSDVYPDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MRGLTPKNGVHI
---CCCCCCCCCCCC		34.7321440633
20PhosphorylationETGPDTESSADSSNF
CCCCCCCCCCCCCCC		32.6819779198
21PhosphorylationTGPDTESSADSSNFS
CCCCCCCCCCCCCCC		29.8428889911
34AcetylationFSTGFSGKIRKPRSK
CCCCCCCCCCCCHHH		37.8325381059
89PhosphorylationRIKNLHKTSLEGTTV
EEEEEEECCCCCCEE		28.0021551504
90PhosphorylationIKNLHKTSLEGTTVQ
EEEEEECCCCCCEEE		29.2719779198
102PhosphorylationTVQVKEETDSSSTSF
EEEEEECCCCCCCCC		42.1230377154
104PhosphorylationQVKEETDSSSTSFSN
EEEECCCCCCCCCCC		33.3430377154
105PhosphorylationVKEETDSSSTSFSNP
EEECCCCCCCCCCCC		40.2130377154
106PhosphorylationKEETDSSSTSFSNPQ
EECCCCCCCCCCCCC		31.8330377154
108PhosphorylationETDSSSTSFSNPQRC
CCCCCCCCCCCCCCC		28.7325752575
110PhosphorylationDSSSTSFSNPQRCTD
CCCCCCCCCCCCCCC		47.5728889911
138PhosphorylationNFKLGGRSSGDNSGS
CCCCCCCCCCCCCCC		41.7817563356
145PhosphorylationSSGDNSGSDGKNDDD
CCCCCCCCCCCCCCC		42.9028889911
342PhosphorylationQKMNLLPSTPSSISS
HHCCCCCCCCCCCCC		53.5822369663
343PhosphorylationKMNLLPSTPSSISSA
HCCCCCCCCCCCCCC		25.8322369663
345PhosphorylationNLLPSTPSSISSAGS
CCCCCCCCCCCCCCC		40.1522369663
346PhosphorylationLLPSTPSSISSAGSP
CCCCCCCCCCCCCCC		27.9122369663
348PhosphorylationPSTPSSISSAGSPNT
CCCCCCCCCCCCCCC		18.9822369663
349PhosphorylationSTPSSISSAGSPNTA
CCCCCCCCCCCCCCC		34.6722369663
352PhosphorylationSSISSAGSPNTAHTK
CCCCCCCCCCCCCCC		18.0722369663
355PhosphorylationSSAGSPNTAHTKSHV
CCCCCCCCCCCCHHH		24.1722369663
358PhosphorylationGSPNTAHTKSHVALV
CCCCCCCCCHHHHHH		31.6022369663
881PhosphorylationSGFHLTVSQMLKNRK
CCCEEEHHHHHHCCC		12.4930377154
919PhosphorylationPDLPSLKTGTSCLLN
CCCCCCCCCCCHHHC		51.4930377154
930PhosphorylationCLLNGIESPQLPFNG
HHHCCCCCCCCCCCC		18.9428152593
939PhosphorylationQLPFNGRSAPSPVRN
CCCCCCCCCCCCCCC		46.0222369663
942PhosphorylationFNGRSAPSPVRNNSL
CCCCCCCCCCCCCCC		35.4322369663
948PhosphorylationPSPVRNNSLPEFAQL
CCCCCCCCCHHHHCC		49.1822369663
957PhosphorylationPEFAQLPSFRSLSVS
HHHHCCCCCCCCCHH		41.7129136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NGG1_YEASTNGG1physical
8663102
STB5_YEASTSTB5physical
15123673
IMB3_YEASTPSE1physical
11136452
PDR3_YEASTPDR3physical
12453227
ERG3_YEASTERG3genetic
10933641
FZO1_YEASTFZO1genetic
10980204
PDR3_YEASTPDR3genetic
10980204
SNQ2_YEASTSNQ2genetic
7629127
PDR3_YEASTPDR3genetic
8078477
PDR3_YEASTPDR3genetic
15632430
ELM1_YEASTELM1genetic
16751665
CLA4_YEASTCLA4genetic
16751665
GIN4_YEASTGIN4genetic
16751665
NAP1_YEASTNAP1genetic
16751665
PDR3_YEASTPDR3genetic
17881724
PDR3_YEASTPDR3genetic
17993571
KSS1_YEASTKSS1genetic
19269370
PFKA1_YEASTPFK1genetic
19269370
PDR1_YEASTPDR1physical
19345193
DEP1_YEASTDEP1genetic
20093466
SWD3_YEASTSWD3genetic
20093466
RS6A_YEASTRPS6Bgenetic
20093466
RS6B_YEASTRPS6Bgenetic
20093466
NGR1_YEASTNGR1genetic
20093466
STE50_YEASTSTE50genetic
20093466
RS14A_YEASTRPS14Agenetic
20093466
MTU1_YEASTSLM3genetic
20093466
NHP10_YEASTNHP10genetic
20093466
TPS2_YEASTTPS2genetic
20093466
EAF1_YEASTEAF1genetic
20093466
SDC1_YEASTSDC1genetic
20093466
RS26B_YEASTRPS26Bgenetic
20093466
YFD4_YEASTYFL034Wgenetic
20093466
WWM1_YEASTWWM1genetic
20093466
SA155_YEASTSAP155genetic
20093466
DUG1_YEASTDUG1genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
RSSA1_YEASTRPS0Agenetic
20093466
SMI1_YEASTSMI1genetic
20093466
YG51_YEASTYGR237Cgenetic
20093466
YOR1_YEASTYOR1genetic
20093466
IGO2_YEASTIGO2genetic
20093466
PTPA1_YEASTRRD1genetic
20093466
DAL4_YEASTDAL4genetic
20093466
RS21B_YEASTRPS21Bgenetic
20093466
YJH0_YEASTYJL070Cgenetic
20093466
DOHH_YEASTLIA1genetic
20093466
YJ9J_YEASTYJR142Wgenetic
20093466
CBT1_YEASTCBT1genetic
20093466
KKQ8_YEASTKKQ8genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
IXR1_YEASTIXR1genetic
20093466
DBP7_YEASTDBP7genetic
20093466
FPS1_YEASTFPS1genetic
20093466
BPT1_YEASTBPT1genetic
20093466
RL31B_YEASTRPL31Bgenetic
20093466
GTR1_YEASTGTR1genetic
20093466
TCB3_YEASTTCB3genetic
20093466
HFA1_YEASTHFA1genetic
20093466
ADE_YEASTAAH1genetic
20093466
ATG3_YEASTATG3genetic
20093466
MSN1_YEASTMSN1genetic
20093466
AIM39_YEASTAIM39genetic
20093466
ROD1_YEASTROD1genetic
20093466
BUB3_YEASTBUB3genetic
20093466
DFG16_YEASTDFG16genetic
20093466
LIPA_YEASTLIP5genetic
20093466
SYH1_YEASTSYH1genetic
20093466
RLM1_YEASTRLM1genetic
20093466
CHL1_YEASTCHL1genetic
20093466
ROX1_YEASTROX1genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
RPD3_YEASTRPD3genetic
18205807
PP11_YEASTSIT4genetic
20608983
PDR3_YEASTPDR3genetic
20851956
SWI4_YEASTSWI4genetic
20831804
HIR1_YEASTHIR1genetic
21127252
PPS1_YEASTPPS1genetic
21127252
RPN4_YEASTRPN4genetic
21127252
KCC4_YEASTKCC4genetic
21127252
PPZ2_YEASTPPZ2genetic
21127252
ZUO1_YEASTZUO1physical
22203981
SSZ1_YEASTSSZ1physical
22203981
MED16_YEASTSIN4genetic
22137896
PDR3_YEASTPDR3genetic
19884123
BEM2_YEASTBEM2genetic
24201294
BMH1_YEASTBMH1genetic
24201294
CWH43_YEASTCWH43genetic
24201294
SGPL_YEASTDPL1genetic
24201294
FMC1_YEASTFMC1genetic
24201294
GCN5_YEASTGCN5genetic
24201294
GTR2_YEASTGTR2genetic
24201294
IMB4_YEASTKAP123genetic
24201294
GET1_YEASTGET1genetic
24201294
PLMT_YEASTOPI3genetic
24201294
PIB2_YEASTPIB2genetic
24201294
AAKG_YEASTSNF4genetic
24201294
RPN10_YEASTRPN10genetic
24201294
SPT7_YEASTSPT7genetic
24201294
SRB8_YEASTSRB8genetic
24201294
SSZ1_YEASTSSZ1genetic
24201294
SWI4_YEASTSWI4genetic
24201294
UME6_YEASTUME6genetic
24201294
YME1_YEASTYME1genetic
24201294
MED19_YEASTROX3genetic
24201294
RCY1_YEASTRCY1genetic
24201294
PDR3_YEASTPDR3genetic
24201294
DEP1_YEASTDEP1genetic
24201294
SLX5_YEASTSLX5genetic
24201294
MNN10_YEASTMNN10genetic
24201294
SPT8_YEASTSPT8genetic
24201294
HEK2_YEASTHEK2genetic
24201294
PDR3_YEASTPDR3genetic
24610064
PDR3_YEASTPDR3genetic
25724885
PDR5_YEASTPDR5genetic
27245696
SEA4_YEASTSEA4genetic
27708008
MRC1_YEASTMRC1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
LPLA_YEASTAIM22genetic
27708008
IXR1_YEASTIXR1genetic
27708008
FABG_YEASTOAR1genetic
27708008
VIP1_YEASTVIP1genetic
27708008
GTR1_YEASTGTR1genetic
27708008
HFA1_YEASTHFA1genetic
27708008
YHM2_YEASTYHM2genetic
27708008
LIPA_YEASTLIP5genetic
27708008
SWD1_YEASTSWD1genetic
27708008
SLA1_YEASTSLA1genetic
27708008
AVT5_YEASTAVT5genetic
27708008
TPS1_YEASTTPS1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
NGR1_YEASTNGR1genetic
27708008
RV161_YEASTRVS161genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
NHP10_YEASTNHP10genetic
27708008
MTU1_YEASTSLM3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
BDF2_YEASTBDF2genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
TPS2_YEASTTPS2genetic
27708008
RS17B_YEASTRPS17Bgenetic
27708008
SDC1_YEASTSDC1genetic
27708008
RL27B_YEASTRPL27Bgenetic
27708008
YD514_YEASTYDR514Cgenetic
27708008
STL1_YEASTSTL1genetic
27708008
IES5_YEASTIES5genetic
27708008
SCS2_YEASTSCS2genetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
BEM2_YEASTBEM2genetic
27708008
BMH1_YEASTBMH1genetic
27708008
YFD4_YEASTYFL034Wgenetic
27708008
RL29_YEASTRPL29genetic
27708008
SA155_YEASTSAP155genetic
27708008
DUG1_YEASTDUG1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
RTF1_YEASTRTF1genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
SMI1_YEASTSMI1genetic
27708008
YG51_YEASTYGR237Cgenetic
27708008
LRP1_YEASTLRP1genetic
27708008
PTPA1_YEASTRRD1genetic
27708008
DAL4_YEASTDAL4genetic
27708008
MHP1_YEASTMHP1genetic
27708008
YJH0_YEASTYJL070Cgenetic
27708008
GSH1_YEASTGSH1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
RPA34_YEASTRPA34genetic
27708008
DOHH_YEASTLIA1genetic
27708008
YJ9J_YEASTYJR142Wgenetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
DBR1_YEASTDBR1genetic
27708008
KAPC_YEASTTPK3genetic
27708008
DPH2_YEASTDPH2genetic
27708008
DBP7_YEASTDBP7genetic
27708008
SRP40_YEASTSRP40genetic
27708008
BPT1_YEASTBPT1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
BRE2_YEASTBRE2genetic
27708008
RAD5_YEASTRAD5genetic
27708008
COA4_YEASTCOA4genetic
27708008
TCB3_YEASTTCB3genetic
27708008
RCO1_YEASTRCO1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
ASI3_YEASTASI3genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
ADE_YEASTAAH1genetic
27708008
ATG3_YEASTATG3genetic
27708008
RRP6_YEASTRRP6genetic
27708008
PALA_YEASTRIM20genetic
27708008
CHL1_YEASTCHL1genetic
27708008
YP068_YEASTYPL068Cgenetic
27708008
RLM1_YEASTRLM1genetic
27708008
COX10_YEASTCOX10genetic
27708008
ROX1_YEASTROX1genetic
27708008
MED1_YEASTMED1genetic
27708008
YP078_YEASTYPR078Cgenetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
SUE1_YEASTSUE1genetic
27708008
NGG1_YEASTNGG1physical
28122947
PDR3_YEASTPDR3genetic
28361556
STB5_YEASTSTB5genetic
28361556
PDR5_YEASTPDR5genetic
28361556
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; SER-110; SER-348;SER-948 AND SER-957, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138 AND SER-942, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-948, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-942, AND MASSSPECTROMETRY.

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