PPS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPS1_YEAST
• UniProt AC: P38148
• Protein Name: Dual specificity protein phosphatase PPS1
• Gene Name: PPS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 807
• Protein Description: Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle..
• Protein Sequence: MVLEVPSITPGELHDLMRLHQDAEWPECKKMFPWAHDISFGQPPDFPHSLAIVKSQSDANNSALLRNSLEVNDIFQSWKVRTSFHREGDTCETGNDSNGFQYPNNTKELLNLLKFQIRQLELQVDDVALENAATYCHNHSILPFLKVDPRGLSLELKRYSRNKVGSNTTLKRSGQDVWGRRGLFRRFDLQCAKMIEMVDNIVIYCSRTGGSTDMQTESAPACSHEGNCPNCTTLALLLQICLMFVQKGYVGSGGSLYKTNLFICTYQNFNTDIPQTLIGTPLLDNEFFKNNTPLNLCSSPSEIVCFNNVDKNMVLCEKLELNKLTSATRLEETGLICGNTTDWHNYQIIKKNNISLTHRFEENTSIVNLKSLNYDTDNPTTSISQLYNIPNTKEVWKLIIKCTSNSQMPSLTKIRTYLDLLLDDDASKSQEHLHLTFPASGSIGLGNLNIQSVEILLNVCYLIFQVSQVQELLTFMYCEDGYTETSLLLTAYIIFHFNIPLQDALLRIHPRPFFLFPSDLQILGHLQPVLREFSPQNGSNLKLYANALKFRDKSFQLHISSELFSSIFFMKIPLESNFVNLKGPLPSRILRHLYLGSLDHAQNPALLKSLGITHIVSVGEVVSWTLNKDKIAHPVRPHRAITMTNTNEVAGNTTCNKSRNRADTVVSDKQENGSNVVISENSGFQICQIENLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNVIIQPNLFFVYELFKWWKKHYNREKDKTMDWHIICRGIAEVNMKYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
364	Phosphorylation	THRFEENTSIVNLKS EEECCCCCEEEEEEC	24.10	21126336
365	Phosphorylation	HRFEENTSIVNLKSL EECCCCCEEEEEECC	35.80	30377154
576	Phosphorylation	FMKIPLESNFVNLKG EEECCCCCCCCCCCC	43.16	27017623
642	Phosphorylation	VRPHRAITMTNTNEV CCCCCEEEECCCCCC	19.56	23749301
646	Phosphorylation	RAITMTNTNEVAGNT CEEEECCCCCCCCCC	24.48	28889911
664	Phosphorylation	KSRNRADTVVSDKQE CCCCCCCEEEEECCH	23.09	17287358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPS1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR8_YEAST	ADE13	physical	11805837
RAS2_YEAST	RAS2	genetic	9083070
SERA_YEAST	SER3	physical	18719252
PP2C1_YEAST	PTC1	genetic	19269370
PKH3_YEAST	PKH3	genetic	19269370
CTK2_YEAST	CTK2	genetic	19269370
MNN11_YEAST	MNN11	genetic	19269370
ADK_YEAST	ADO1	genetic	19269370
CTK1_YEAST	CTK1	genetic	19269370
ETR1_YEAST	ETR1	genetic	20093466
RSC2_YEAST	RSC2	genetic	20093466
ETR1_YEAST	ETR1	genetic	27708008
IMG2_YEAST	IMG2	genetic	27708008
HOOK2_HUMAN	HOOK2	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-664, AND MASSSPECTROMETRY.
PubMed: 17287358