PUR8_YEAST - dbPTM
PUR8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUR8_YEAST
UniProt AC Q05911
Protein Name Adenylosuccinate lyase
Gene Name ADE13
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 482
Subcellular Localization
Protein Description
Protein Sequence MPDYDNYTTPLSSRYASKEMSATFSLRNRFSTWRKLWLNLAIAEKELGLTVVTDEAIEQMRKHVEITDDEIAKASAQEAIVRHDVMAHVHTFGETCPAAAGIIHLGATSCFVTDNADLIFIRDAYDIIIPKLVNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARNDIGLRGVKGTTGTQASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKMATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENIIMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLEPSTFVGRAPQQVEKFVQKDVNNALQPFQKYLNDEQVKLNV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPDYDNYTTPL
----CCCCCCCCCCC		10.5422369663
7Phosphorylation-MPDYDNYTTPLSSR
-CCCCCCCCCCCHHH		14.7522369663
8PhosphorylationMPDYDNYTTPLSSRY
CCCCCCCCCCCHHHH		28.3522369663
9PhosphorylationPDYDNYTTPLSSRYA
CCCCCCCCCCHHHHC		16.3322369663
12PhosphorylationDNYTTPLSSRYASKE
CCCCCCCHHHHCCCC		17.6122369663
13PhosphorylationNYTTPLSSRYASKEM
CCCCCCHHHHCCCCC		36.6722369663
21PhosphorylationRYASKEMSATFSLRN
HHCCCCCCCCEEHHH		25.8327017623
67PhosphorylationMRKHVEITDDEIAKA
HHHHCCCCHHHHHHH		24.7221126336
73AcetylationITDDEIAKASAQEAI
CCHHHHHHHHHHHHH		48.8424489116
131AcetylationAYDIIIPKLVNVINR
HHHHHHHHHHHHHHH		55.4424489116
141AcetylationNVINRLAKFAMEYKD
HHHHHHHHHHHHCCC		37.9424489116
196UbiquitinationDIGLRGVKGTTGTQA
CCCCCCCCCCCCCHH		54.0512872131
215AcetylationLFHGNHDKVEALDER
HHCCCHHHHHHHHHH		34.1324489116
231AcetylationTELLGFDKVYPVTGQ
HHHHCCCEEEECCCC		41.2124489116
231UbiquitinationTELLGFDKVYPVTGQ
HHHHCCCEEEECCCC		41.2122817900
273UbiquitinationIRLLANLKEVEEPFE
HHHHHHHHHCCCCHH		60.5723749301
273SuccinylationIRLLANLKEVEEPFE
HHHHHHHHHCCCCHH		60.5723954790
281AcetylationEVEEPFEKSQIGSSA
HCCCCHHHCCCCCCH		48.3024489116
282PhosphorylationVEEPFEKSQIGSSAM
CCCCHHHCCCCCCHH		21.6022369663
286PhosphorylationFEKSQIGSSAMAYKR
HHHCCCCCCHHHHHC		19.2928889911
287PhosphorylationEKSQIGSSAMAYKRN
HHCCCCCCHHHHHCC		19.4919779198
292AcetylationGSSAMAYKRNPMRCE
CCCHHHHHCCHHHHH		35.8422865919
404PhosphorylationHERIRVLSHQAAAVV
HHHHHHHHHHHHHHH		15.6528889911
456AcetylationRAPQQVEKFVQKDVN
CCHHHHHHHHHHHHH		52.5622865919
471AcetylationNALQPFQKYLNDEQV
HHHHHHHHHHCHHHC		52.6824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUR8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUR8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUR8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EIF3B_YEASTPRT1physical
11805826
PUR6_YEASTADE2genetic
10822807
PUR1_YEASTADE4genetic
15744050
PUR8_YEASTADE13physical
18719252
APT1_YEASTAPT1genetic
16941010
APT2_YEASTAPT2genetic
16941010
ADK_YEASTADO1genetic
16941010
GSH1_YEASTGSH1genetic
21623372
HXKB_YEASTHXK2genetic
21623372
ADH6_YEASTADH6genetic
21623372
MDHP_YEASTMDH3genetic
21623372
FUMH_YEASTFUM1genetic
21623372
PLB2_YEASTPLB2genetic
21623372
PUR1_YEASTADE4genetic
21623372
TPS3_YEASTTPS3genetic
21623372
ADH2_YEASTADH2genetic
21623372
QCR9_YEASTQCR9genetic
21623372
ODPA_YEASTPDA1genetic
21623372
TPS2_YEASTTPS2genetic
21623372
CSG2_YEASTCSG2genetic
21623372
ERG2_YEASTERG2genetic
21623372
TPS1_YEASTTPS1genetic
21623372
PFKA1_YEASTPFK1genetic
21623372
HPRT_YEASTHPT1genetic
21623372
METX_YEASTYML082Wgenetic
21623372
CHO2_YEASTCHO2genetic
21623372
ATPO_YEASTATP5genetic
21623372
SGPL_YEASTDPL1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
DCE_YEASTGAD1genetic
21623372
QCR7_YEASTQCR7genetic
21623372
KPR4_YEASTPRS4genetic
21623372
CBS_YEASTCYS4genetic
21623372
ECT1_YEASTECT1genetic
21623372
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUR8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4 AND THR-9, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-196, AND MASSSPECTROMETRY.

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