ADH6_YEAST - dbPTM
ADH6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADH6_YEAST
UniProt AC Q04894
Protein Name NADP-dependent alcohol dehydrogenase 6
Gene Name ADH6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 360
Subcellular Localization
Protein Description NADP-dependent alcohol dehydrogenase with a broad substrate specificity..
Protein Sequence MSYPEKFEGIAIQSHEDWKNPKKTKYDPKPFYDHDIDIKIEACGVCGSDIHCAAGHWGNMKMPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGVGAQVFSCLECDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFVVPIPENIPSHLAAPLLCGGLTVYSPLVRNGCGPGKKVGIVGLGGIGSMGTLISKAMGAETYVISRSSRKREDAMKMGADHYIATLEEGDWGEKYFDTFDLIVVCASSLTDIDFNIMPKAMKVGGRIVSISIPEQHEMLSLKPYGLKAVSISYSALGSIKELNQLLKLVSEKDIKIWVETLPVGEAGVHEAFERMEKGDVRYRFTLVGYDKEFSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSYPEKFEG
------CCCCCCCCC		49.7728889911
25AcetylationWKNPKKTKYDPKPFY
CCCCCCCCCCCCCCC		57.4422865919
99PhosphorylationGVGAQVFSCLECDRC
CCCCEEEEHHCCCCC		20.9525704821
119PhosphorylationPYCTKFVTTYSQPYE
CEEEEEEEEECCCCC		24.1327017623
122PhosphorylationTKFVTTYSQPYEDGY
EEEEEEECCCCCCCC		23.6828889911
131PhosphorylationPYEDGYVSQGGYANY
CCCCCCCCCCCCCCE		18.0228889911
182UbiquitinationNGCGPGKKVGIVGLG
CCCCCCCEEEEEECC		52.1623749301
200UbiquitinationSMGTLISKAMGAETY
HHHHHHHHHHCCCEE		35.0823749301
210PhosphorylationGAETYVISRSSRKRE
CCCEEEEECCHHCHH		18.9628889911
287AcetylationQHEMLSLKPYGLKAV
HHHHHCCCCCCCEEE		32.5824489116
312AcetylationKELNQLLKLVSEKDI
HHHHHHHHHHHHHCC		56.2724489116
315PhosphorylationNQLLKLVSEKDIKIW
HHHHHHHHHHCCEEE		49.73-
3172-HydroxyisobutyrylationLLKLVSEKDIKIWVE
HHHHHHHHCCEEEEE		58.19-
317SuccinylationLLKLVSEKDIKIWVE
HHHHHHHHCCEEEEE		58.1923954790
350PhosphorylationGDVRYRFTLVGYDKE
CCCEEEEEEEEECCC		16.1321126336
356UbiquitinationFTLVGYDKEFSD---
EEEEEECCCCCC---		52.7723749301
359PhosphorylationVGYDKEFSD------
EEECCCCCC------		43.4321082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADH6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADH6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADH6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADH6_YEASTADH6physical
15289102
SSB1_YEASTSSB1physical
19536198
STE50_YEASTSTE50genetic
20093466
RV167_YEASTRVS167genetic
20093466
IES5_YEASTIES5genetic
20093466
UBP3_YEASTUBP3genetic
20093466
GCN20_YEASTGCN20genetic
20093466
YG51_YEASTYGR237Cgenetic
20093466
RL40A_YEASTRPL40Bgenetic
20093466
RL40B_YEASTRPL40Bgenetic
20093466
COA4_YEASTCOA4genetic
20093466
FKBP_YEASTFPR1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
ATP23_YEASTATP23genetic
20093466
PP2A4_YEASTPPG1genetic
20093466
BRE5_YEASTBRE5genetic
20093466
MDM12_YEASTMDM12genetic
20093466
GLO4_YEASTGLO4genetic
20093466
MNE1_YEASTMNE1genetic
20093466
HAP5_YEASTHAP5genetic
20093466
GPP2_YEASTGPP2genetic
21623372
ACON2_YEASTACO2genetic
21623372
SGF29_YEASTSGF29genetic
27708008
OMS1_YEASTOMS1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
MNE1_YEASTMNE1genetic
27708008
RV161_YEASTRVS161genetic
27708008
IMG2_YEASTIMG2genetic
27708008
TPS2_YEASTTPS2genetic
27708008
PLP1_YEASTPLP1genetic
27708008
UME6_YEASTUME6genetic
27708008
RV167_YEASTRVS167genetic
27708008
IES5_YEASTIES5genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
YG2G_YEASTYGR079Wgenetic
27708008
ASF1_YEASTASF1genetic
27708008
RL40A_YEASTRPL40Bgenetic
27708008
RL40B_YEASTRPL40Bgenetic
27708008
SIC1_YEASTSIC1genetic
27708008
COA4_YEASTCOA4genetic
27708008
SWS2_YEASTSWS2genetic
27708008
ATP23_YEASTATP23genetic
27708008
PP2A4_YEASTPPG1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
MTHR1_YEASTMET12genetic
27708008
LGE1_YEASTLGE1genetic
27708008
COX10_YEASTCOX10genetic
27708008
YME1_YEASTYME1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADH6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122; SER-131; SER-210AND SER-359, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, AND MASSSPECTROMETRY.

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