| UniProt ID | TCPH_YEAST | |
|---|---|---|
| UniProt AC | P42943 | |
| Protein Name | T-complex protein 1 subunit eta | |
| Gene Name | CCT7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 550 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).. | |
| Protein Sequence | MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAGRGRGMPM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MNFGSQTPTIVV ---CCCCCCCCEEEE | 27.09 | 27214570 | |
| 7 | Phosphorylation | -MNFGSQTPTIVVLK -CCCCCCCCEEEEEE | 24.89 | 28152593 | |
| 9 | Phosphorylation | NFGSQTPTIVVLKEG CCCCCCCEEEEEECC | 29.77 | 19795423 | |
| 71 | Acetylation | NDGATILKLLDVVHP CCHHHHHHHHHHHCH | 43.06 | 24489116 | |
| 71 | Ubiquitination | NDGATILKLLDVVHP CCHHHHHHHHHHHCH | 43.06 | 24961812 | |
| 81 | Ubiquitination | DVVHPAAKTLVDISR HHHCHHHHHHHCHHH | 44.49 | 24961812 | |
| 113 | Acetylation | GELMKEAKPFLEEGI HHHHHHHHHHHHHCH | 37.08 | 24489116 | |
| 127 | Acetylation | ISSHLIMKGYRKAVS HHHHHHHHHHHHHHH | 45.88 | 24489116 | |
| 148 | Phosphorylation | NELAVDITSEKSSGR HHHHCCCCCCCCCHH | 26.77 | 19795423 | |
| 149 | Phosphorylation | ELAVDITSEKSSGRE HHHCCCCCCCCCHHH | 43.28 | 19795423 | |
| 151 | Acetylation | AVDITSEKSSGRELL HCCCCCCCCCHHHHH | 50.08 | 24489116 | |
| 169 | Acetylation | ARTAMSSKLIHNNAD HHHHHHHCHHHCCCH | 44.12 | 24489116 | |
| 226 | Phosphorylation | AFKKTFSYAGFEQQP EEEEECCCCCCCCCC | 13.42 | 19779198 | |
| 254 | Ubiquitination | ELELKAEKDNAEVRV EEEEEECCCCCEEEE | 62.23 | 23749301 | |
| 288 | Phosphorylation | KLRQVEETGANIVLS HHHCHHHHCCCEEEE | 28.26 | 22369663 | |
| 295 | Phosphorylation | TGANIVLSKLPIGDL HCCCEEEEECCCHHH | 22.66 | 22369663 | |
| 416 | Phosphorylation | IVAGGGATEMEVSKC EEECCCHHHHHHHHH | 38.86 | 27017623 | |
| 421 | Phosphorylation | GATEMEVSKCLRDYS CHHHHHHHHHHHHHH | 12.35 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCPH_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCPH_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCPH_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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