VATG_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATG_YEAST
• UniProt AC: P48836
• Protein Name: V-type proton ATPase subunit G
• Gene Name: VMA10
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 114
• Protein Description: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MSQKNGIATLLQAEKEAHEIVSKARKYRQDKLKQAKTDAAKEIDSYKIQKDKELKEFEQKNAGGVGELEKKAEAGVQGELAEIKKIAEKKKDDVVKILIETVIKPSAEVHINAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSQKNGIAT ------CCCHHHHHH	50.27	22814378
4	Ubiquitination	----MSQKNGIATLL ----CCCHHHHHHHH	50.24	24961812
15	Ubiquitination	ATLLQAEKEAHEIVS HHHHHHHHHHHHHHH	64.32	24961812
15	Acetylation	ATLLQAEKEAHEIVS HHHHHHHHHHHHHHH	64.32	24489116
22	Phosphorylation	KEAHEIVSKARKYRQ HHHHHHHHHHHHHHH	26.68	28889911
23	Acetylation	EAHEIVSKARKYRQD HHHHHHHHHHHHHHH	41.12	24489116
31	Acetylation	ARKYRQDKLKQAKTD HHHHHHHHHHHHCHH	49.61	24489116
41	Succinylation	QAKTDAAKEIDSYKI HHCHHHHHHHHHHHH	57.85	23954790
41	Acetylation	QAKTDAAKEIDSYKI HHCHHHHHHHHHHHH	57.85	24489116
47	Acetylation	AKEIDSYKIQKDKEL HHHHHHHHHHCCHHH	42.48	24489116
47	2-Hydroxyisobutyrylation	AKEIDSYKIQKDKEL HHHHHHHHHHCCHHH	42.48	-
55	Acetylation	IQKDKELKEFEQKNA HHCCHHHHHHHHHCC	62.54	24489116
60	Succinylation	ELKEFEQKNAGGVGE HHHHHHHHCCCCHHH	41.38	23954790
60	Acetylation	ELKEFEQKNAGGVGE HHHHHHHHCCCCHHH	41.38	24489116
60	Ubiquitination	ELKEFEQKNAGGVGE HHHHHHHHCCCCHHH	41.38	23749301
70	Acetylation	GGVGELEKKAEAGVQ CCHHHHHHHHHHHCC	70.66	24489116
70	Ubiquitination	GGVGELEKKAEAGVQ CCHHHHHHHHHHHCC	70.66	22817900
71	Ubiquitination	GVGELEKKAEAGVQG CHHHHHHHHHHHCCH	41.92	22817900
84	Acetylation	QGELAEIKKIAEKKK CHHHHHHHHHHHHCC	29.63	24489116
91	2-Hydroxyisobutyrylation	KKIAEKKKDDVVKIL HHHHHHCCCCHHHHH	70.94	-
101	Phosphorylation	VVKILIETVIKPSAE HHHHHHHHHHCCCCC	22.12	19795423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATG_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATG_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATG_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATG_YEAST	VMA10	physical	12832076
VATA_YEAST	VMA1	physical	15751969
VATB_YEAST	VMA2	physical	15751969
VATE_YEAST	VMA4	physical	15751969
VATA_YEAST	VMA1	physical	9334266
VATB_YEAST	VMA2	physical	9334266
VATE_YEAST	VMA4	physical	9334266
VATD_YEAST	VMA8	physical	9334266
VATF_YEAST	VMA7	physical	9334266
PRP3_YEAST	PRP3	physical	16554755
VATD_YEAST	VMA8	physical	16554755
CLG1_YEAST	CLG1	physical	16554755
RRP14_YEAST	RRP14	physical	16554755
CUE1_YEAST	CUE1	physical	16554755
VATH_YEAST	VMA13	physical	16554755
VATB_YEAST	VMA2	physical	12960158
VATC_YEAST	VMA5	physical	12960158
VATD_YEAST	VMA8	physical	12960158
VATE_YEAST	VMA4	physical	12960158
VATF_YEAST	VMA7	physical	12960158
VATH_YEAST	VMA13	physical	12960158
VATA_YEAST	VMA1	physical	12960158
VATA_YEAST	VMA1	physical	18955482
VATH_YEAST	VMA13	physical	18955482
VATF_YEAST	VMA7	physical	18955482
VATE_YEAST	VMA4	physical	18955482
VATD_YEAST	VMA8	physical	18955482
VATC_YEAST	VMA5	physical	18955482
VATB_YEAST	VMA2	physical	18955482
VATE_YEAST	VMA4	physical	16774922
VATG_YEAST	VMA10	physical	16774922
VATB_YEAST	VMA2	physical	16774922
VATD_YEAST	VMA8	physical	16774922
VATF_YEAST	VMA7	physical	16774922
VATA_YEAST	VMA1	physical	16774922
VATH_YEAST	VMA13	physical	16774922
VATC_YEAST	VMA5	physical	16774922
VATH_YEAST	VMA13	physical	23071676
VATB_YEAST	VMA2	physical	23071676
VATF_YEAST	VMA7	physical	23071676
VATD_YEAST	VMA8	physical	23071676
VPH1_YEAST	VPH1	physical	23071676
VATE_YEAST	VMA4	physical	23142977
VPH1_YEAST	VPH1	physical	23142977
PEP8_YEAST	PEP8	genetic	24326069

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.