SDS22_YEAST - dbPTM
SDS22_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SDS22_YEAST
UniProt AC P36047
Protein Name Protein phosphatase 1 regulatory subunit SDS22
Gene Name SDS22
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 338
Subcellular Localization Nucleus.
Protein Description Regulator of the mitotic function of yeast type 1 protein phosphatase..
Protein Sequence MDKNSVNKDSEEKDERHKIEVVDDTNPDFITADSELTQDLPDDVEVIDLVHLKIKSLEDLNLYRFKNLKQLCLRQNLIESISEVEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLINLHPLKNLKILSIQSNKLKKIENLEELTNLEELYLSHNFITKIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQSFESLGENLSALSRLETIYLEGNPIQLENKTSYRRKLTMNLPPSLQKIDATYIRG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MDKNSVNKDSEE
---CCCCCCCCCCHH		32.5722369663
8AcetylationMDKNSVNKDSEEKDE
CCCCCCCCCCHHHHH		61.5525381059
10PhosphorylationKNSVNKDSEEKDERH
CCCCCCCCHHHHHHH		49.6322369663
55AcetylationDLVHLKIKSLEDLNL
EEEEEEECCHHHCCC		47.6124489116
56PhosphorylationLVHLKIKSLEDLNLY
EEEEEECCHHHCCCH		40.2322369663
63PhosphorylationSLEDLNLYRFKNLKQ
CHHHCCCHHCCCHHH		16.9624930733
80PhosphorylationLRQNLIESISEVEVL
HHHHHHHHHHEEECC		25.1528889911
107PhosphorylationNKIKHISSNVNKLTK
CHHHHHHHCHHHHHH		44.1627017623
113PhosphorylationSSNVNKLTKLTSLDL
HHCHHHHHHHHHCCC		26.1427017623
116PhosphorylationVNKLTKLTSLDLSFN
HHHHHHHHHCCCCHH		28.8827017623
124AcetylationSLDLSFNKIKHIKNL
HCCCCHHHHHHCCCC		51.6324489116
126AcetylationDLSFNKIKHIKNLEN
CCCHHHHHHCCCCCC		40.6724489116
129AcetylationFNKIKHIKNLENLTD
HHHHHHCCCCCCCCC		56.0224489116
158PhosphorylationENLSTLKSLKNLELG
CCHHHHHHHCCCEEC		47.9229688323
214AcetylationILSIQSNKLKKIENL
EEEECCCCCHHCCCH		67.9224489116
2482-HydroxyisobutyrylationEGLEKNLKLTTLDVT
HHHHHCCCEEEEECC		53.86-
293PhosphorylationESLGENLSALSRLET
HHHHHHHHHHHHHEE		38.4527017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SDS22_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SDS22_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SDS22_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PP12_YEASTGLC7physical
11805826
PP12_YEASTGLC7physical
11805837
REG1_YEASTREG1physical
11805837
NOP6_YEASTNOP6physical
11805837
PMA1_YEASTPMA1physical
11805837
NSR1_YEASTNSR1physical
11805837
NET1_YEASTNET1physical
11805837
KOG1_YEASTKOG1physical
11805837
YG3A_YEASTYGR130Cphysical
11805837
HXT6_YEASTHXT6physical
11805837
RSE1_YEASTRSE1physical
11805837
AAKG_YEASTSNF4physical
11805837
PPZ2_YEASTPPZ2physical
11805837
RUVB1_YEASTRVB1physical
11805837
PMA2_YEASTPMA2physical
11805837
PP12_YEASTGLC7physical
7791784
PP12_YEASTGLC7physical
11801737
PP12_YEASTGLC7genetic
11801737
PP12_YEASTGLC7genetic
7791784
PP12_YEASTGLC7physical
16429126
SET1_YEASTSET1genetic
16143104
NIP80_YEASTNIP100physical
14660704
PPZ1_YEASTPPZ1physical
14660704
SNF1_YEASTSNF1physical
14660704
STU1_YEASTSTU1physical
14660704
YBB0_YEASTYBL010Cphysical
14660704
VPS8_YEASTVPS8physical
14660704
YPI1_YEASTYPI1physical
17142459
PP12_YEASTGLC7physical
17142459
SIC1_YEASTSIC1physical
18467557
SNT1_YEASTSNT1genetic
20093466
CSM1_YEASTCSM1genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
AIM11_YEASTAIM11genetic
20093466
BLM10_YEASTBLM10genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
IMB5_YEASTKAP114genetic
20093466
VAM7_YEASTVAM7genetic
20093466
HUR1_YEASTHUR1genetic
20093466
AROC_YEASTARO2genetic
20093466
CSK2B_YEASTCKB1genetic
20093466
VPS29_YEASTVPS29genetic
20093466
YHU0_YEASTYHR140Wgenetic
20093466
STB5_YEASTSTB5genetic
20093466
ACA2_YEASTCST6genetic
20093466
MNN11_YEASTMNN11genetic
20093466
RL17B_YEASTRPL17Bgenetic
20093466
HAL5_YEASTHAL5genetic
20093466
RPA34_YEASTRPA34genetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
AP3S_YEASTAPS3genetic
20093466
RL43A_YEASTRPL43Bgenetic
20093466
RL43B_YEASTRPL43Bgenetic
20093466
MDM35_YEASTMDM35genetic
20093466
BRE2_YEASTBRE2genetic
20093466
ALAM_YEASTALT1genetic
20093466
RL37A_YEASTRPL37Agenetic
20093466
YPT6_YEASTYPT6genetic
20093466
RS30A_YEASTRPS30Agenetic
20093466
RS30B_YEASTRPS30Agenetic
20093466
RL6B_YEASTRPL6Bgenetic
20093466
SST2_YEASTSST2genetic
20093466
SMA2_YEASTSMA2genetic
20093466
BCH1_YEASTBCH1genetic
20093466
YHM2_YEASTYHM2genetic
20093466
SCS7_YEASTSCS7genetic
20093466
FAR11_YEASTFAR11genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
ATO2_YEASTATO2genetic
20093466
DUS2_YEASTSMM1genetic
20093466
YO159_YEASTYOL159Cgenetic
20093466
RTG1_YEASTRTG1genetic
20093466
NTH2_YEASTNTG2genetic
20093466
NOP12_YEASTNOP12genetic
20093466
MDM12_YEASTMDM12genetic
20093466
STI1_YEASTSTI1genetic
20093466
CY1_YEASTCYT1genetic
20093466
VAM3_YEASTVAM3genetic
20093466
LEO1_YEASTLEO1genetic
20093466
MDL2_YEASTMDL2genetic
20093466
AP1M1_YEASTAPM1genetic
20093466
FLC1_YEASTFLC1genetic
20093466
NCBP2_YEASTCBC2genetic
20093466
ARL3_YEASTARL3genetic
20093466
THP3_YEASTTHP3genetic
20093466
PPAL_YEASTLTP1genetic
20093466
MDM36_YEASTMDM36genetic
20093466
QCR2_YEASTQCR2genetic
20093466
PP12_YEASTGLC7physical
23418575
BUB3_YEASTBUB3physical
23894419
HAL5_YEASTHAL5genetic
22282571
STU1_YEASTSTU1genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
CDC48_YEASTCDC48genetic
27708008
CDC53_YEASTCDC53genetic
27708008
ERF3_YEASTSUP35genetic
27708008
PP12_YEASTGLC7genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SP105_YEASTSPC105genetic
27708008
DAM1_YEASTDAM1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
BET3_YEASTBET3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
SPC24_YEASTSPC24genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DPOA_YEASTPOL1genetic
27708008
CAP_YEASTSRV2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
SGT1_YEASTSGT1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
NIP7_YEASTNIP7genetic
27708008
SEC23_YEASTSEC23genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
HUR1_YEASTHUR1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
SST2_YEASTSST2genetic
27708008
HDA1_YEASTHDA1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
STI1_YEASTSTI1genetic
27708008
MAS5_YEASTYDJ1genetic
29674565
STU1_YEASTSTU1genetic
29674565
KPC1_YEASTPKC1genetic
29674565
CCZ1_YEASTCCZ1genetic
29674565
CKS1_YEASTCKS1genetic
29674565
UME6_YEASTUME6genetic
29674565
GPI19_YEASTGPI19genetic
29674565
ATC1_YEASTPMR1genetic
29674565
SSF1_YEASTSSF1genetic
29674565
ARP1_YEASTARP1genetic
29674565
DYHC_YEASTDYN1genetic
29674565
LDB18_YEASTLDB18genetic
29674565
RIC1_YEASTRIC1genetic
29674565
SCS7_YEASTSCS7genetic
29674565
DYN3_YEASTDYN3genetic
29674565
TPT1_YEASTTPT1genetic
29674565
STI1_YEASTSTI1genetic
29674565
EXO1_YEASTEXO1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SDS22_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND MASSSPECTROMETRY.

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