ASI1_YEAST - dbPTM
ASI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASI1_YEAST
UniProt AC P54074
Protein Name Protein ASI1
Gene Name ASI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 624
Subcellular Localization Nucleus inner membrane
Multi-pass membrane protein .
Protein Description Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals..
Protein Sequence MNSSTSSENVFINSFSYLNQTSQAVISGNSTFANVINFPYRLGLSFIGAVNLQYEQTVKSEEIPPTLRSVFDTIGFFFSPYAIFCFVIAIVLNRFVVFYAVLNNGSRRTLPLWLSNVFHVSAVVVLAMVSLGPLTLGKDFKILGDPAFAQEKFLLNIFYAFAYSYCVETIFTIMRNSSPLEGTDYSLFELSIQFYTMTNNNTKFLDSPDYIIDCSMAILSRILIHLVEIFRLRNYRLLFSTIMNLCHICYLGIRVKQGGWKSLPFSVKFRHFPKLFSVSIICLSLLIFKLSCLIRWDPFGKSRNSCELLQFYPLSRNWKKYLNYTGEEDFSAMATKFALLLCSGTELMEKGIRREFPAINIPDNVNEKFFISGYLNELSKPYKENTSISFPKKNSSILKQRFFLMFPKSIIWIMKKLVGQVFFGFRDNKDEDIPDNDPSKMLKITKTNSLNNSAGHKEDIELELLNTSDDEYSEDYEPSEVESLGDSDEENLEEDSLIFNETRDALLDLFSSEDNEVHTDYNWIMSTSRILQQKLLSDKTLTRASILDTKLSEVDETFGTESDFDLSCAVCKVNERNTVLWPCRCFAICEDCRISLGLRGFSTCVCCRSKVHGYCKVHPVSDSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2N-linked_Glycosylation------MNSSTSSEN
------CCCCCCCCC		44.6716735580
19N-linked_GlycosylationINSFSYLNQTSQAVI
ECEEHHHCCCCCEEC		34.5516735580
29N-linked_GlycosylationSQAVISGNSTFANVI
CCEECCCCCHHHHHC		30.9616735580
447PhosphorylationKMLKITKTNSLNNSA
HHHHEEECCCCCCCC		22.7628889911
449PhosphorylationLKITKTNSLNNSAGH
HHEEECCCCCCCCCC		37.3928889911
562PhosphorylationDETFGTESDFDLSCA
CHHHCCCCCCCEEEE		43.3327214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ASI3_YEASTASI3physical
17085444
YIM1_YEASTYIM1genetic
16269340
KAR5_YEASTKAR5genetic
16269340
STE50_YEASTSTE50genetic
20093466
YCA2_YEASTYCL002Cgenetic
20093466
VAM7_YEASTVAM7genetic
20093466
ASK10_YEASTASK10genetic
20093466
ATG32_YEASTATG32genetic
20093466
GSH1_YEASTGSH1genetic
20093466
MDM12_YEASTMDM12genetic
20093466
PHO80_YEASTPHO80genetic
20093466
YP260_YEASTYPL260Wgenetic
20093466
GGPPS_YEASTBTS1genetic
20093466
SMA1_YEASTSMA1genetic
20093466
CHL1_YEASTCHL1genetic
20093466
YP096_YEASTYPR096Cgenetic
20093466
DAL81_YEASTDAL81genetic
17603098
CP51_YEASTERG11physical
25236469
ASI2_YEASTASI2physical
25236469
ASI3_YEASTASI3physical
25236469
HRD1_YEASTHRD1genetic
25236469
IRE1_YEASTIRE1genetic
25236469
CP51_YEASTERG11genetic
25236469
MCES_YEASTABD1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
COPD_YEASTRET2genetic
27708008
ALG2_YEASTALG2genetic
27708008
IF2A_YEASTSUI2genetic
27708008
OST2_YEASTOST2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
KRR1_YEASTKRR1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
NSE4_YEASTNSE4genetic
27708008
SC61G_YEASTSSS1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
TRS23_YEASTTRS23genetic
27708008
SMT3_YEASTSMT3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
KTHY_YEASTCDC8genetic
27708008
GFA1_YEASTGFA1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
ORC1_YEASTORC1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
RRP44_YEASTDIS3genetic
27708008
RPB2_YEASTRPB2genetic
27708008
ETR1_YEASTETR1genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
RV161_YEASTRVS161genetic
27708008
CSN9_YEASTCSN9genetic
27708008
SNF6_YEASTSNF6genetic
27708008
ATG32_YEASTATG32genetic
27708008
VPS53_YEASTVPS53genetic
27708008
GSH1_YEASTGSH1genetic
27708008
IXR1_YEASTIXR1genetic
27708008
ELM1_YEASTELM1genetic
27708008
RL1D1_YEASTUTP30genetic
27708008
RL38_YEASTRPL38genetic
27708008
HDA1_YEASTHDA1genetic
27708008
ATP23_YEASTATP23genetic
27708008
PHO80_YEASTPHO80genetic
27708008
SIN3_YEASTSIN3genetic
27708008
SMA1_YEASTSMA1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
YP096_YEASTYPR096Cgenetic
27708008
UBC7_YEASTUBC7physical
25519137
UBC6_YEASTUBC6physical
25519137
FATE1_HUMANFATE1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASI1_YEAST

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Inner nuclear membrane proteins Asi1, Asi2, and Asi3 function inconcert to maintain the latent properties of transcription factorsStp1 and Stp2.";
Zargari A., Boban M., Heessen S., Andreasson C., Thyberg J.,Ljungdahl P.O.;
J. Biol. Chem. 282:594-605(2007).
Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-2; ASN-19 ANDASN-29, AND INTERACTION WITH ASI3.
"Asi1 is an inner nuclear membrane protein that restricts promoteraccess of two latent transcription factors.";
Boban M., Zargari A., Andreasson C., Heessen S., Thyberg J.,Ljungdahl P.O.;
J. Cell Biol. 173:695-707(2006).
Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-2; ASN-19 ANDASN-29, TOPOLOGY, AND MUTAGENESIS OF CYS-583 AND CYS-585.

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