| UniProt ID | CHS2_YEAST | |
|---|---|---|
| UniProt AC | P14180 | |
| Protein Name | Chitin synthase 2 | |
| Gene Name | CHS2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 963 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Essential for septum formation and cell division. CHS2 is required for maintaining normal cell morphology.. | |
| Protein Sequence | MTRNPFMVEPSNGSPNRRGASNLSKFYANANSNSRWANPSEESLEDSYDQSNVFQGLPASPSRAALRYSPDRRHRTQFYRDSAHNSPVAPNRYAANLQESPKRAGEAVIHLSEGSNLYPRDNADLPVDPYHLSPQQQPSNNLFGSGRLYSQSSKYTMSTTSTTAPSLAEADDEKEKYLTSTTSYDDQSTIFSADTFNETKFELNHPTRQQYVRRANSESKRRMVSDLPPPSKKKALLKLDNPIPKGLLDTLPRRNSPEFTEMRYTACTVEPDDFLREGYTLRFAEMNRECQIAICITMYNEDKYSLARTIHSIMKNVAHLCKREKSHVWGPNGWKKVSVILISDGRAKVNQGSLDYLAALGVYQEDMAKASVNGDPVKAHIFELTTQVSINADLDYVSKDIVPVQLVFCLKEENKKKINSHRWLFNAFCPVLQPTVVTLVDVGTRLNNTAIYRLWKVFDMDSNVAGAAGQIKTMKGKWGLKLFNPLVASQNFEYKISNILDKPLESVFGYISVLPGALSAYRYRALKNHEDGTGPLRSYFLGETQEGRDHDVFTANMYLAEDRILCWELVAKRDAKWVLKYVKEATGETDVPEDVSEFISQRRRWLNGAMFAAIYAQLHFYQIWKTKHSVVRKFFLHVEFLYQFIQMLFSWFSIANFVLTFYYLAGSMNLVIKHGEALFIFFKYLIFCDLASLFIISMGNRPQGAKHLFITSMVILSICATYSLICGFVFAFKSLASGTESHKIFVDIVISLLSTYGLYFFSSLMYLDPWHMFTSSIQYFLTLPAFTCTLQIFAFCNTHDVSWGTKGSTQESKQLSKAIVVQGPDGKQIVETDWPQEVDKKFLEIKSRLKEPEFEESSGNEKQSKNDYYRDIRTRIVMIWMLSNLILIMSIIQVFTPQDTDNGYLIFILWSVAALAAFRVVGSMAFLFMKYLRIIVSYRNKVEGSGSWEVSKLDLPNVFHKKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | NPFMVEPSNGSPNRR CCCCCCCCCCCCCCC | 40.07 | 21082442 | |
| 14 | Phosphorylation | MVEPSNGSPNRRGAS CCCCCCCCCCCCCCC | 24.21 | 21082442 | |
| 22 | N-linked_Glycosylation | PNRRGASNLSKFYAN CCCCCCCCHHHHHHC | 48.04 | - | |
| 32 | Phosphorylation | KFYANANSNSRWANP HHHHCCCCCCCCCCC | 33.50 | 23749301 | |
| 40 | Phosphorylation | NSRWANPSEESLEDS CCCCCCCCHHHHHHC | 54.53 | 19684113 | |
| 43 | Phosphorylation | WANPSEESLEDSYDQ CCCCCHHHHHHCCCC | 32.76 | 19684113 | |
| 47 | Phosphorylation | SEESLEDSYDQSNVF CHHHHHHCCCCCCCC | 22.64 | 23749301 | |
| 48 | Phosphorylation | EESLEDSYDQSNVFQ HHHHHHCCCCCCCCC | 30.26 | 23749301 | |
| 51 | Phosphorylation | LEDSYDQSNVFQGLP HHHCCCCCCCCCCCC | 31.87 | 28889911 | |
| 60 | Phosphorylation | VFQGLPASPSRAALR CCCCCCCCCCHHHHH | 22.82 | 19684113 | |
| 62 | Phosphorylation | QGLPASPSRAALRYS CCCCCCCCHHHHHCC | 31.86 | 19779198 | |
| 69 | Phosphorylation | SRAALRYSPDRRHRT CHHHHHCCCCCCCCC | 17.56 | 17563356 | |
| 76 | Phosphorylation | SPDRRHRTQFYRDSA CCCCCCCCCCHHCCC | 19.53 | 28889911 | |
| 79 | Phosphorylation | RRHRTQFYRDSAHNS CCCCCCCHHCCCCCC | 12.05 | 23749301 | |
| 82 | Phosphorylation | RTQFYRDSAHNSPVA CCCCHHCCCCCCCCC | 23.56 | 11875433 | |
| 86 | Phosphorylation | YRDSAHNSPVAPNRY HHCCCCCCCCCCCHH | 15.75 | 11875433 | |
| 100 | Phosphorylation | YAANLQESPKRAGEA HHHCCCCCCCHHCCE | 23.82 | 22369663 | |
| 102 | Ubiquitination | ANLQESPKRAGEAVI HCCCCCCCHHCCEEE | 65.25 | 23749301 | |
| 130 | Phosphorylation | ADLPVDPYHLSPQQQ CCCCCCCCCCCCCCC | 15.78 | 22369663 | |
| 133 | Phosphorylation | PVDPYHLSPQQQPSN CCCCCCCCCCCCCCC | 13.83 | 22369663 | |
| 145 | Phosphorylation | PSNNLFGSGRLYSQS CCCCCCCCCCCEECC | 17.26 | 23749301 | |
| 158 | Phosphorylation | QSSKYTMSTTSTTAP CCCCEEECCCCCCCC | 22.27 | 23749301 | |
| 159 | Phosphorylation | SSKYTMSTTSTTAPS CCCEEECCCCCCCCC | 17.59 | 23749301 | |
| 160 | Phosphorylation | SKYTMSTTSTTAPSL CCEEECCCCCCCCCH | 19.44 | 23749301 | |
| 161 | Phosphorylation | KYTMSTTSTTAPSLA CEEECCCCCCCCCHH | 24.69 | 23749301 | |
| 162 | Phosphorylation | YTMSTTSTTAPSLAE EEECCCCCCCCCHHC | 25.53 | 23749301 | |
| 163 | Phosphorylation | TMSTTSTTAPSLAEA EECCCCCCCCCHHCC | 36.02 | 24961812 | |
| 166 | Phosphorylation | TTSTTAPSLAEADDE CCCCCCCCHHCCCCH | 37.43 | 23749301 | |
| 174 | Ubiquitination | LAEADDEKEKYLTST HHCCCCHHHHHCCCC | 67.51 | 23749301 | |
| 177 | Phosphorylation | ADDEKEKYLTSTTSY CCCHHHHHCCCCCCC | 19.12 | 28889911 | |
| 179 | Phosphorylation | DEKEKYLTSTTSYDD CHHHHHCCCCCCCCC | 22.42 | 28889911 | |
| 181 | Phosphorylation | KEKYLTSTTSYDDQS HHHHCCCCCCCCCCC | 17.96 | 28889911 | |
| 182 | Phosphorylation | EKYLTSTTSYDDQST HHHCCCCCCCCCCCC | 25.67 | 27017623 | |
| 183 | Phosphorylation | KYLTSTTSYDDQSTI HHCCCCCCCCCCCCE | 27.01 | 27017623 | |
| 184 | Phosphorylation | YLTSTTSYDDQSTIF HCCCCCCCCCCCCEE | 22.80 | 28889911 | |
| 188 | Phosphorylation | TTSYDDQSTIFSADT CCCCCCCCCEEECCC | 30.39 | 28889911 | |
| 197 | N-linked_Glycosylation | IFSADTFNETKFELN EEECCCCCCCCCCCC | 59.11 | - | |
| 217 | Phosphorylation | QYVRRANSESKRRMV HHHHHCCCHHHHHCH | 42.11 | 17287358 | |
| 225 | Phosphorylation | ESKRRMVSDLPPPSK HHHHHCHHCCCCCCH | 24.88 | 21440633 | |
| 231 | Phosphorylation | VSDLPPPSKKKALLK HHCCCCCCHHHHHHH | 63.98 | 28889911 | |
| 232 | Ubiquitination | SDLPPPSKKKALLKL HCCCCCCHHHHHHHC | 65.16 | 23749301 | |
| 234 | Ubiquitination | LPPPSKKKALLKLDN CCCCCHHHHHHHCCC | 48.26 | 17644757 | |
| 238 | Ubiquitination | SKKKALLKLDNPIPK CHHHHHHHCCCCCCC | 55.43 | 17644757 | |
| 245 | Ubiquitination | KLDNPIPKGLLDTLP HCCCCCCCCHHHCCC | 64.01 | 23749301 | |
| 256 | Phosphorylation | DTLPRRNSPEFTEMR HCCCCCCCCCCCCCE | 24.80 | 28889911 | |
| 280 | Phosphorylation | DFLREGYTLRFAEMN HHHHCCCEEEHHHHC | 23.47 | 25533186 | |
| 447 | N-linked_Glycosylation | VDVGTRLNNTAIYRL EECCHHCCCHHHHHH | 40.28 | - | |
| 462 | Phosphorylation | WKVFDMDSNVAGAAG HHHHCCCCCCCCCHH | 26.94 | 23607784 | |
| 473 | Phosphorylation | GAAGQIKTMKGKWGL CCHHHCEECCCCHHH | 26.24 | 23607784 | |
| 481 | Ubiquitination | MKGKWGLKLFNPLVA CCCCHHHHHCCHHHH | 47.28 | 17644757 | |
| 495 | Ubiquitination | ASQNFEYKISNILDK HCCCCEEEHHHHCCC | 32.25 | 17644757 | |
| 583 | Ubiquitination | KWVLKYVKEATGETD HHHHHHHHHHHCCCC | 38.24 | 23749301 | |
| 813 | Ubiquitination | KGSTQESKQLSKAIV CCCHHHHHHHHEEEE | 55.28 | 23749301 | |
| 817 | Ubiquitination | QESKQLSKAIVVQGP HHHHHHHEEEEEECC | 51.21 | 17644757 | |
| 827 | Ubiquitination | VVQGPDGKQIVETDW EEECCCCCCEECCCC | 44.20 | 17644757 | |
| 840 | Ubiquitination | DWPQEVDKKFLEIKS CCCHHHHHHHHHHHH | 51.07 | 17644757 | |
| 841 | Ubiquitination | WPQEVDKKFLEIKSR CCHHHHHHHHHHHHH | 51.20 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CHS2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CHS2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CHS2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-82; SER-86 ANDSER-133, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-82; SER-86;SER-100 AND SER-133, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-217, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82 AND SER-86, AND MASSSPECTROMETRY. | |
