FEN2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEN2_YEAST
• UniProt AC: P25621
• Protein Name: Pantothenate transporter FEN2
• Gene Name: FEN2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 512
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Transports pantothenate into the cell. Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance..
• Protein Sequence: MMKESKSITQHEVERESVSSKRAIKKRLLLFKIDLFVLSFVCLQYWINYVDRVGFTNAYISGMKEDLKMVGNDLTVSNTVFMIGYIVGMVPNNLMLLCVPPRIWLSFCTFAWGLLTLGMYKVTSFKHICAIRFFQALFESCTFSGTHFVLGSWYKEDELPIRSAIFTGSGLVGSMFSGFMQTSIFTHLNGRNGLAGWRWLFIIDFCITLPIAIYGFIFFPGLPDQTSAVSKFSMTRYIFNEQELHYARRRLPARDESTRLDWSTIPRVLKRWHWWMFSLVWVLGGENLGFASNSTFALWLQNQKYTLAQRNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVLIRADPLNPKVVFSAQYLGGVAYAGQAVFFSWANIICHADLQERAIVLASMNMFSGAVNAWWSILFFASDMVPKFERGCYALLATAISSGIVSVVIRSLQIKENLSKKQVPYIDANDMPGEDDDDDNQDNENDGDDESMEVELHNEEMAEISNPFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MMKESKSITQHEVE -CCCCCCCCCHHHHH	39.90	23749301
9	Phosphorylation	MKESKSITQHEVERE CCCCCCCCHHHHHHH	30.85	24961812
17	Phosphorylation	QHEVERESVSSKRAI HHHHHHHHHCCHHHH	33.26	28889911
19	Phosphorylation	EVERESVSSKRAIKK HHHHHHHCCHHHHHH	39.15	28889911
20	Phosphorylation	VERESVSSKRAIKKR HHHHHHCCHHHHHHH	24.81	28889911
109	Phosphorylation	RIWLSFCTFAWGLLT HHHHHHHHHHHHHHH	17.87	27017623
116	Phosphorylation	TFAWGLLTLGMYKVT HHHHHHHHHCCCCCC	26.72	27017623
120	Phosphorylation	GLLTLGMYKVTSFKH HHHHHCCCCCCCHHH	10.66	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEN2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEN2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEN2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHO88_YEAST	PHO88	physical	16093310
MST27_YEAST	MST27	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
YN94_YEAST	YNR065C	physical	16093310
SEC63_YEAST	SEC63	physical	16093310

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.