EMC4_YEAST - dbPTM
EMC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EMC4_YEAST
UniProt AC P53073
Protein Name ER membrane protein complex subunit 4
Gene Name EMC4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 190
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER)..
Protein Sequence MSEQEPYEWAKHLLDTKYIEKYNIQNSNTLPSPPGFEGNSSKGNVTRKQQDATSQTTSLAQKNQITVLQVQKAWQIALQPAKSIPMNIFMSYMSGTSLQIIPIMTALMLLSGPIKAIFSTRSAFKPVLGNKATQSQVQTAMFMYIVFQGVLMYIGYRKLNSMGLIPNAKGDWLPWERIAHYNNGLQWFSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11AcetylationQEPYEWAKHLLDTKY
CCHHHHHHHHHCCHH		35.5424489116
16PhosphorylationWAKHLLDTKYIEKYN
HHHHHHCCHHHHHCC		26.2215665377
17AcetylationAKHLLDTKYIEKYNI
HHHHHCCHHHHHCCC		43.8524489116
21UbiquitinationLDTKYIEKYNIQNSN
HCCHHHHHCCCCCCC		33.7617644757
21AcetylationLDTKYIEKYNIQNSN
HCCHHHHHCCCCCCC		33.7624489116
40PhosphorylationPPGFEGNSSKGNVTR
CCCCCCCCCCCCCCH		44.2623749301
42UbiquitinationGFEGNSSKGNVTRKQ
CCCCCCCCCCCCHHH		55.0917644757
48UbiquitinationSKGNVTRKQQDATSQ
CCCCCCHHHHCCCHH		42.8423749301
53PhosphorylationTRKQQDATSQTTSLA
CHHHHCCCHHHCCHH		29.6521126336
62UbiquitinationQTTSLAQKNQITVLQ
HHCCHHHHCCEEEEE		45.2517644757
125UbiquitinationFSTRSAFKPVLGNKA
HCCCCCCHHHCCCCC		33.6523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EMC4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EMC4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EMC4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLMT_YEASTOPI3genetic
16269340
SSH1_YEASTSSH1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
SCS7_YEASTSCS7genetic
16269340
GET1_YEASTGET1genetic
16269340
ERG4_YEASTERG4genetic
16269340
SWA2_YEASTSWA2genetic
16269340
ICE2_YEASTICE2genetic
16269340
HACD_YEASTPHS1genetic
16269340
ILM1_YEASTILM1genetic
16269340
GET2_YEASTGET2genetic
19325107
VPS28_YEASTVPS28genetic
19325107
CUE1_YEASTCUE1genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
RPN4_YEASTRPN4genetic
19325107
SEC22_YEASTSEC22genetic
19325107
UBC7_YEASTUBC7genetic
19325107
SSH1_YEASTSSH1genetic
19325107
ICE2_YEASTICE2genetic
23891562
KPC1_YEASTPKC1genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RIFK_YEASTFMN1genetic
27708008
RPB7_YEASTRPB7genetic
27708008
CP51_YEASTERG11genetic
27708008
BRL1_YEASTBRL1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
PAN1_YEASTPAN1genetic
27708008
MED14_YEASTRGR1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DCP2_YEASTDCP2genetic
27708008
APC5_YEASTAPC5genetic
27708008
NAB3_YEASTNAB3genetic
27708008
SSH1_YEASTSSH1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
GET1_YEASTGET1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
LEO1_YEASTLEO1genetic
27708008
TYSY_YEASTCDC21genetic
29674565
MSH2_YEASTMSH2genetic
29674565
CHO2_YEASTCHO2genetic
29674565
INO2_YEASTINO2genetic
29674565
NUM1_YEASTNUM1genetic
29674565
TRS23_YEASTTRS23genetic
29674565
PPN1_YEASTPPN1genetic
29674565
GET2_YEASTGET2genetic
29674565
GET1_YEASTGET1genetic
29674565
RPN1_YEASTRPN1genetic
29674565
BRL1_YEASTBRL1genetic
29674565
ICE2_YEASTICE2genetic
29674565
ELM1_YEASTELM1genetic
29674565
POB3_YEASTPOB3genetic
29674565
RNA1_YEASTRNA1genetic
29674565
DCP2_YEASTDCP2genetic
29674565
APC5_YEASTAPC5genetic
29674565
GGPPS_YEASTBTS1genetic
29674565
MED10_YEASTNUT2genetic
29674565
CEM1_YEASTCEM1genetic
29674565
DBP9_YEASTDBP9genetic
29674565
AMPD_YEASTAMD1genetic
29674565
TGS1_YEASTTGS1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EMC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-16, AND MASSSPECTROMETRY.

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