MNL1_YEAST - dbPTM
MNL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MNL1_YEAST
UniProt AC P38888
Protein Name ER degradation-enhancing alpha-mannosidase-like protein 1
Gene Name MNL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 796
Subcellular Localization Endoplasmic reticulum lumen .
Protein Description Alpha-1,2-specific exomannosidase involved in endoplasmic reticulum-associated degradation (ERAD). Delivers misfolded glycoproteins to proteasomes. Forms a complex with PDI1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response..
Protein Sequence MVCCLWVLLALLLHLDHVACEDDAYSFTSKELKAYKQEVKELFYFGFDNYLEHGYPYDEVKPISCVPKKRNFEDPTDQGTNDILGNFTITLIDSLTTIAILEDRPQFLKAVRLVERTFPDGNFDIDSTIQVFEITIRVIGSLLSSHLYATDPTKAVYLGDDYDGSLLRLAQNMADRLLPAYLTSTGLPMPRRNIKRKWDVSEFPEFLETENNVAAMASPMFEFTILSYLTGDPKYEKVTRYAFDKTWSLRTGLDLLPMSFHPEKLTPYTPMTGIGASIDSLFEYALKGAILFDDSELMEVWNVAYEALKTNCKNDWFFANVMADTGHLFVPWIDSLSAFFSGLQVLAGDLDDAIANHLMFLKMWNTFGGIPERWNFSPPEFPPLSPLERSGAVALDNILPLEWYPLRPEFFESTYFLYRATKDPFYLNIGVHLLKDLKQRFKSNCGFAGFQNVITGELQDRMETFVLSETLKYLYLLFDEENELHNSASDVIFSTEAHPMWLPQEVRSNYKRNAKFNNSVYSSHLEICQKKDREQAGENTLSQRIVGFAKSIFHKGPPDEEATDPIIDYTIDTELPGTCSIKPHHVIGDEFWYSPMLSNFDRLFEIDSRFAATLIKPSHMHNYNAIELEPGFYNRWSNPQFSTCLIPPTTEIFELLFDLPGYHQLNPLMLENKTITFETFGGRSRLKIEKLQIYQIDYYGDLITASTFQDVSRKDIFSNACDAVASLYSPTYLYRVVAINGRILPRHGSVQIKKHSPVLTSNGTREEDEFKMDGIGINDHSQLMLECTPIINLFIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
86N-linked_GlycosylationGTNDILGNFTITLID
CCCCHHHCCEEEEEH		27.69-
517N-linked_GlycosylationYKRNAKFNNSVYSSH
CCCCCCCCCCHHHHH		38.88-
672N-linked_GlycosylationLNPLMLENKTITFET
CCCEEECCCEEEEEE		42.69-
762N-linked_GlycosylationHSPVLTSNGTREEDE
CCCCEECCCCCCCCC		51.09-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MNL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MNL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MNL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL30_YEASTRPL30physical
10688190
NSA2_YEASTNSA2physical
10688190
PDI_YEASTPDI1physical
16554755
NDH2_YEASTNDE2physical
16554755
RFA2_YEASTRFA2physical
16554755
FMO1_YEASTFMO1genetic
16269340
YDC1_YEASTYDC1genetic
16269340
ARV1_YEASTARV1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
GET1_YEASTGET1genetic
16269340
BFR1_YEASTBFR1genetic
16269340
PDI_YEASTPDI1physical
19124653
PDI_YEASTPDI1physical
19279007
RL20A_YEASTRPL20Bgenetic
14764870
RL20B_YEASTRPL20Bgenetic
14764870
LCF3_YEASTFAA3genetic
23891562
CKS1_YEASTCKS1genetic
27708008
RPB1_YEASTRPO21genetic
27708008
ACT_YEASTACT1genetic
27708008
NU159_YEASTNUP159genetic
27708008
SRP54_YEASTSRP54genetic
27708008
PDI_YEASTPDI1physical
27053108
PDI_YEASTPDI1physical
27357682
IRE1_YEASTIRE1genetic
26184977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MNL1_YEAST

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Related Literatures of Post-Translational Modification

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