SPC25_YEAST - dbPTM
SPC25_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPC25_YEAST
UniProt AC P40014
Protein Name Kinetochore protein SPC25
Gene Name SPC25
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 221
Subcellular Localization Nucleus . Chromosome, centromere, kinetochore . Associated with kinetochores.
Protein Description Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity..
Protein Sequence MASIDAFSDLERRMDGFQKDVAQVLARQQNHARQQLQQFQAEMRQLHNQHQHLIDELQRLATQRTALQQQIHAAQQATNTTREQWRSYHERESELSRRQSTLAAQSRELDSLLQQRGKECVQLRARWAAQSGNDAAEVALYERLLQLRVLPGASDVHDVRFVFGDDSRCWIEVAMHGDHVIGNSHPALDPKSRATLEHVLTVQGDLAAFLVVARDMLLASL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MASIDAFSD
------CCCCHHHHH
18.3922814378
100PhosphorylationSELSRRQSTLAAQSR
HHHHHHHHHHHHHHH
24.4730377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPC25_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPC25_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPC25_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NUF2_YEASTNUF2physical
11179222
SPC24_YEASTSPC24physical
11179222
NDC80_YEASTNDC80physical
11266451
NUF2_YEASTNUF2physical
11266451
SPC24_YEASTSPC24physical
11266451
NDC80_YEASTNDC80physical
11179222
SPC25_YEASTSPC25physical
11179222
NDC80_YEASTNDC80genetic
11179222
SPC24_YEASTSPC24genetic
11179222
YD073_YEASTYDL073Wphysical
16554755
SPC24_YEASTSPC24physical
16554755
NUF2_YEASTNUF2physical
16429126
SPC24_YEASTSPC24physical
16429126
NDC80_YEASTNDC80physical
16429126
DEP1_YEASTDEP1physical
17634282
UBC4_YEASTUBC4physical
17634282
CYC8_YEASTCYC8physical
17634282
AROG_YEASTARO4physical
17634282
PAT1_YEASTPAT1physical
17634282
SLX5_YEASTSLX5physical
17634282
PRP9_YEASTPRP9physical
17634282
MBP1_YEASTMBP1physical
17634282
ATG20_YEASTATG20physical
17634282
NOT2_YEASTCDC36physical
17634282
MFG1_YEASTMFG1physical
17634282
NSI1_YEASTNSI1physical
17634282
SWI5_YEASTSWI5physical
17634282
ADA2_YEASTADA2physical
17634282
SPC25_YEASTSPC25physical
17634282
EPL1_YEASTEPL1physical
17634282
FAR7_YEASTFAR7physical
17634282
KEG1_YEASTKEG1physical
17634282
CNN1_YEASTCNN1physical
17634282
SGF73_YEASTSGF73physical
17634282
ASK10_YEASTASK10physical
17634282
PXR1_YEASTPXR1physical
17634282
SNF6_YEASTSNF6physical
17634282
RSC30_YEASTRSC30physical
17634282
MED6_YEASTMED6physical
17634282
THP2_YEASTTHP2physical
17634282
SSP1_YEASTSSP1physical
17634282
SKN7_YEASTSKN7physical
17634282
SDS3_YEASTSDS3physical
17634282
FKH1_YEASTFKH1physical
17634282
DSN1_YEASTDSN1physical
17634282
MND2_YEASTMND2physical
17634282
NUP82_YEASTNUP82physical
17634282
ATG36_YEASTATG36physical
17634282
PRP40_YEASTPRP40physical
17634282
DAL80_YEASTDAL80physical
17634282
NAP1_YEASTNAP1physical
17634282
YL031_YEASTYLR031Wphysical
17634282
SOK2_YEASTSOK2physical
17634282
CEF1_YEASTCEF1physical
17634282
JNM1_YEASTJNM1physical
17634282
PHO23_YEASTPHO23physical
17634282
BSC5_YEASTBSC5physical
17634282
SWI1_YEASTSWI1physical
17634282
GCR1_YEASTGCR1physical
17634282
RDS2_YEASTRDS2physical
17634282
NIP80_YEASTNIP100physical
17634282
YP257_YEASTYPL257Wphysical
17634282
RLF2_YEASTRLF2physical
17634282
YP022_YEASTYPR022Cphysical
17634282
MCM16_YEASTMCM16physical
17634282
MDM36_YEASTMDM36physical
17634282
MTW1_YEASTMTW1physical
18286174
MUM2_YEASTMUM2physical
18719252
PAN3_YEASTPAN3physical
18719252
ADA2_YEASTADA2physical
18719252
TED1_YEASTTED1genetic
19325107
EMC2_YEASTEMC2genetic
19325107
NUF2_YEASTNUF2physical
22875988
TYE7_YEASTTYE7physical
22875988
NDC80_YEASTNDC80physical
25230952
SPC24_YEASTSPC24physical
25230952
SP105_YEASTSPC105physical
24930965
DSN1_YEASTDSN1physical
24930965
NSL1_YEASTNSL1physical
24930965
CDC11_YEASTCDC11genetic
27708008
SIN3_YEASTSIN3genetic
27708008
DAD1_YEASTDAD1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
SRPR_YEASTSRP101genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SP105_YEASTSPC105genetic
27708008
TAF6_YEASTTAF6genetic
27708008
PRP43_YEASTPRP43genetic
27708008
DAM1_YEASTDAM1genetic
27708008
OKP1_YEASTOKP1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
IPI1_YEASTIPI1genetic
27708008
ORC6_YEASTORC6genetic
27708008
NDC80_YEASTNDC80genetic
27708008
DSN1_YEASTDSN1genetic
27708008
ARP4_YEASTARP4genetic
27708008
IF2A_YEASTSUI2genetic
27708008
HSP77_YEASTSSC1genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
GSP1_YEASTGSP1genetic
27708008
SPC24_YEASTSPC24genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
NOP2_YEASTNOP2genetic
27708008
SMC5_YEASTSMC5genetic
27708008
RIB2_YEASTRIB2genetic
27708008
NUF2_YEASTNUF2genetic
27708008
TYSY_YEASTCDC21genetic
27708008
ESA1_YEASTESA1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
YBF9_YEASTYBL059Wgenetic
27708008
CHK1_YEASTCHK1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
SAC3_YEASTSAC3genetic
27708008
UME6_YEASTUME6genetic
27708008
RT103_YEASTRTT103genetic
27708008
CYM1_YEASTCYM1genetic
27708008
LCMT1_YEASTPPM1genetic
27708008
IZH1_YEASTIZH1genetic
27708008
KCC1_YEASTCMK1genetic
27708008
GEP7_YEASTGEP7genetic
27708008
MDM34_YEASTMDM34genetic
27708008
MTC3_YEASTMTC3genetic
27708008
RTF1_YEASTRTF1genetic
27708008
PHB2_YEASTPHB2genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
SWE1_YEASTSWE1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
MIC60_YEASTMIC60genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
APC9_YEASTAPC9genetic
27708008
CST9_YEASTCST9genetic
27708008
ATP18_YEASTATP18genetic
27708008
PUR1_YEASTADE4genetic
27708008
YME2_YEASTYME2genetic
27708008
VAM3_YEASTVAM3genetic
27708008
CA094_HUMANC1orf94physical
27107014
USBP1_HUMANUSHBP1physical
27107014
RBP1_HUMANRALBP1physical
27107014
NUP62_HUMANNUP62physical
27107014
IKZF3_HUMANIKZF3physical
27107014
K1C15_HUMANKRT15physical
27107014
GOGA2_HUMANGOLGA2physical
27107014

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPC25_YEAST

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Related Literatures of Post-Translational Modification

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