GCR1_YEAST - dbPTM
GCR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GCR1_YEAST
UniProt AC P07261
Protein Name Glycolytic genes transcriptional activator GCR1
Gene Name GCR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 785
Subcellular Localization Nucleus.
Protein Description Transcriptional activator required for the expression of glycolytic and ribosomal genes. Forms a transcriptional activation complex with RAP1, RAP1 providing the specific DNA-binding function and GCR1 providing the activation function. Can also bind itself to DNA to a core 5'-CTTCC-3' sequence (CT box). CT box-binding is not essential, but enhances the activation function of the RAP1-GCR1 complex in promoters that contain both DNA signals (only glycolytic genes). CT box-dependent transcriptional activation requires GCR2..
Protein Sequence MVCTSTSSNFYSIAQYILQSYFKVNVDSLNSLKLVDLIVDQTYPDSLTLRKLNEGATGQPYDYFNTVSRDADISKCPIFALTIFFVIRWSHPNPPISIENFTTVPLLDSNFISLNSNPLLYIQNQNPNSNSSVKVSRSQTFEPSKELIDLVFPWLSYLKQDMLLIDRTNYKLYSLCELFEFMGRVAIQDLRYLSQHPLLLPNIVTFISKFIPELFQNEEFKGIGSIKNSNNNALNNVTGIETQFLNPSTEEVSQKVDSYFMELSKKLTTENIRLSQEITQLKADMNSVGNVCNQILLLQRQLLSGNQAIGSKSENIVSSTGGGILILDKNSINSNVLSNLVQSIDPNHSKPNGQAQTHQRGPKGQSHAQVQSTNSPALAPINMFPSLSNSIQPMLGTLAPQPQDIVQKRKLPLPGSIASAATGSPFSPSPVGESPYSKRFKLDDKPTPSQTALDSLLTKSISSPRLPLSTLANTAVTESFRSPQQFQHSPDFVVGGSSSSTTENNSKKVNEDSPSSSSKLAERPRLPNNDSTTSMPESPTEVAGDDVDREKPPESSKSEPNDNSPESKDPEKNGKNSNPLGTDADKPVPISNIHNSTEAANSSGTVTKTAPSFPQSSSKFEIINKKDTKAGPNEAIKYKLSRENKTIWDLYAEWYIGLNGKSSIKKLIENYGWRRWKVSEDSHFFPTRRIIMDYIETECDRGIKLGRFTNPQQPREDIRKILVGDLEKFRINNGLTLNSLSLYFRNLTKNNKEICIFENFKNWNVRSMTEEEKLKYCKRRHNTPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MVCTSTSSNFYSIA
-CCCCCCCCCHHHHH		24.0530377154
12PhosphorylationSTSSNFYSIAQYILQ
CCCCCHHHHHHHHHH		13.8130377154
20PhosphorylationIAQYILQSYFKVNVD
HHHHHHHHHHCCCHH		29.1430377154
31PhosphorylationVNVDSLNSLKLVDLI
CCHHHCCCCCHHHEE		31.9721551504
375PhosphorylationAQVQSTNSPALAPIN
EECCCCCCCCCCCCC		16.1921551504
390PhosphorylationMFPSLSNSIQPMLGT
CCHHHCCCHHHHHCC		21.1621551504
416PhosphorylationRKLPLPGSIASAATG
CCCCCCCCHHHHCCC		17.0317563356
419PhosphorylationPLPGSIASAATGSPF
CCCCCHHHHCCCCCC		19.4321551504
422PhosphorylationGSIASAATGSPFSPS
CCHHHHCCCCCCCCC		37.6023749301
424PhosphorylationIASAATGSPFSPSPV
HHHHCCCCCCCCCCC		20.5817563356
427PhosphorylationAATGSPFSPSPVGES
HCCCCCCCCCCCCCC		28.0521440633
429PhosphorylationTGSPFSPSPVGESPY
CCCCCCCCCCCCCCC		30.9017563356
434PhosphorylationSPSPVGESPYSKRFK
CCCCCCCCCCCCCCC		24.1817563356
436PhosphorylationSPVGESPYSKRFKLD
CCCCCCCCCCCCCCC		35.7824961812
437PhosphorylationPVGESPYSKRFKLDD
CCCCCCCCCCCCCCC		22.2721440633
447PhosphorylationFKLDDKPTPSQTALD
CCCCCCCCCCHHHHH		41.1122369663
449PhosphorylationLDDKPTPSQTALDSL
CCCCCCCCHHHHHHH		42.5122369663
451PhosphorylationDKPTPSQTALDSLLT
CCCCCCHHHHHHHHH		33.2622369663
455PhosphorylationPSQTALDSLLTKSIS
CCHHHHHHHHHHCCC		26.5725521595
458PhosphorylationTALDSLLTKSISSPR
HHHHHHHHHCCCCCC		28.2126447709
460PhosphorylationLDSLLTKSISSPRLP
HHHHHHHCCCCCCCC		23.5922369663
462PhosphorylationSLLTKSISSPRLPLS
HHHHHCCCCCCCCHH		41.1922369663
463PhosphorylationLLTKSISSPRLPLST
HHHHCCCCCCCCHHH		16.6321440633
469PhosphorylationSSPRLPLSTLANTAV
CCCCCCHHHHCCHHH		21.3122369663
470PhosphorylationSPRLPLSTLANTAVT
CCCCCHHHHCCHHHH		37.2622369663
474PhosphorylationPLSTLANTAVTESFR
CHHHHCCHHHHHHCC		19.5219779198
477PhosphorylationTLANTAVTESFRSPQ
HHCCHHHHHHCCCHH		24.3722369663
479PhosphorylationANTAVTESFRSPQQF
CCHHHHHHCCCHHHH		19.3222369663
482PhosphorylationAVTESFRSPQQFQHS
HHHHHCCCHHHHCCC		25.6729136822
489PhosphorylationSPQQFQHSPDFVVGG
CHHHHCCCCCEEECC		18.5119795423
499PhosphorylationFVVGGSSSSTTENNS
EEECCCCCCCCCCCC		33.1419779198
513PhosphorylationSKKVNEDSPSSSSKL
CCCCCCCCCCCCHHH		22.0917563356
515PhosphorylationKVNEDSPSSSSKLAE
CCCCCCCCCCHHHHC		46.9728889911
516PhosphorylationVNEDSPSSSSKLAER
CCCCCCCCCHHHHCC		41.8517563356
517PhosphorylationNEDSPSSSSKLAERP
CCCCCCCCHHHHCCC		35.5127717283
518PhosphorylationEDSPSSSSKLAERPR
CCCCCCCHHHHCCCC		33.3728889911
531PhosphorylationPRLPNNDSTTSMPES
CCCCCCCCCCCCCCC		35.3921551504
532PhosphorylationRLPNNDSTTSMPESP
CCCCCCCCCCCCCCC		26.2521551504
533PhosphorylationLPNNDSTTSMPESPT
CCCCCCCCCCCCCCC		27.2921440633
534PhosphorylationPNNDSTTSMPESPTE
CCCCCCCCCCCCCCC		32.2121440633
538PhosphorylationSTTSMPESPTEVAGD
CCCCCCCCCCCCCCC		31.1121440633
540PhosphorylationTSMPESPTEVAGDDV
CCCCCCCCCCCCCCC		52.9821551504
555PhosphorylationDREKPPESSKSEPND
CCCCCCCCCCCCCCC		49.1726447709
556PhosphorylationREKPPESSKSEPNDN
CCCCCCCCCCCCCCC		38.2426447709
558PhosphorylationKPPESSKSEPNDNSP
CCCCCCCCCCCCCCC		61.3029734811
564PhosphorylationKSEPNDNSPESKDPE
CCCCCCCCCCCCCHH		32.6725521595
567PhosphorylationPNDNSPESKDPEKNG
CCCCCCCCCCHHHCC		45.8221551504
602PhosphorylationNSTEAANSSGTVTKT
CCCCHHHCCCCCEEC		25.9723749301
619AcetylationSFPQSSSKFEIINKK
CCCCCCCCEEEECCC		49.3024489116
767PhosphorylationFKNWNVRSMTEEEKL
CCCCCCCCCCHHHHH		26.2727214570
769PhosphorylationNWNVRSMTEEEKLKY
CCCCCCCCHHHHHHH		41.3027214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GCR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GCR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GCR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCR2_YEASTGCR2physical
7713414
GCR2_YEASTGCR2physical
1508187
RAP1_YEASTRAP1physical
9826662
NUP84_YEASTNUP84physical
15817685
POM34_YEASTPOM34physical
15817685
PO152_YEASTPOM152physical
15817685
IMB4_YEASTKAP123physical
15817685
GCR2_YEASTGCR2genetic
11333224
CG11_YEASTCLN1genetic
14668361
CG12_YEASTCLN2genetic
14668361
CG13_YEASTCLN3genetic
14668361
FKS2_YEASTGSC2genetic
15817685
BSD2_YEASTBSD2genetic
15817685
SPR3_YEASTSPR3genetic
15817685
SPR6_YEASTSPR6genetic
15817685
CDA1_YEASTCDA1genetic
15817685
ALR2_YEASTALR2genetic
15817685
PMP1_YEASTPMP1genetic
15817685
TXTP_YEASTCTP1genetic
15817685
PP2B2_YEASTCMP2genetic
15817685
MHP1_YEASTMHP1genetic
15817685
DBP7_YEASTDBP7genetic
15817685
PP2C3_YEASTPTC3genetic
15817685
ZDS1_YEASTZDS1genetic
15817685
PTK2_YEASTPTK2genetic
15817685
SIC1_YEASTSIC1genetic
15817685
KA122_YEASTKAP122genetic
15817685
IMB4_YEASTKAP123genetic
15817685
NUP84_YEASTNUP84genetic
15817685
GCR2_YEASTGCR2genetic
15817685
NU100_YEASTNUP100genetic
15817685
NU120_YEASTNUP120genetic
15817685
NU133_YEASTNUP133genetic
15817685
NU170_YEASTNUP170genetic
15817685
NU188_YEASTNUP188genetic
15817685
PO152_YEASTPOM152genetic
15817685
POM34_YEASTPOM34genetic
15817685
MSS11_YEASTMSS11genetic
15817685
MAL33_YEASTMAL33genetic
15817685
MAL31_YEASTMAL31genetic
15817685
ALG6_YEASTALG6genetic
15817685
OSH3_YEASTOSH3genetic
15817685
OSH2_YEASTOSH2genetic
15817685
SBA1_YEASTSBA1genetic
15817685
OAC1_YEASTOAC1genetic
15817685
HAP5_YEASTHAP5genetic
15817685
MDHC_YEASTMDH2genetic
15817685
FUMH_YEASTFUM1genetic
15817685
MET3_YEASTMET3genetic
15817685
UBP7_YEASTUBP7genetic
15817685
FKBP2_YEASTFPR2genetic
15817685
PRM3_YEASTPRM3genetic
15817685
RBD2_YEASTRBD2genetic
15817685
RGD2_YEASTRGD2genetic
15817685
TIR4_YEASTTIR4genetic
15817685
NPP1_YEASTNPP1genetic
15817685
YC16_YEASTYCR087C-Agenetic
15817685
MCH1_YEASTMCH1genetic
15817685
YD132_YEASTYDR132Cgenetic
15817685
YEW0_YEASTCOM2genetic
15817685
OCA5_YEASTOCA5genetic
15817685
YHY2_YEASTYHR182Wgenetic
15817685
YJY1_YEASTYJR011Cgenetic
15817685
MTNB_YEASTMDE1genetic
15817685
ATG33_YEASTATG33genetic
15817685
RSF1_YEASTRSF1genetic
15817685
YM8V_YEASTYMR295Cgenetic
15817685
RIM1_YEASTRIM1genetic
15817685
NUP53_YEASTNUP53genetic
15817685
NUP59_YEASTASM4genetic
15817685
ATU1_YEASTPCA1genetic
15817685
PTH_YEASTPTH1genetic
15817685
GCR2_YEASTGCR2genetic
1508187
NUP42_YEASTNUP42genetic
22110603
NUP53_YEASTNUP53genetic
22110603
NUP84_YEASTNUP84genetic
22110603
NU120_YEASTNUP120genetic
22110603
NU133_YEASTNUP133genetic
22110603
GCR2_YEASTGCR2physical
22076377
NKP2_YEASTNKP2physical
22875988
GCR2_YEASTGCR2genetic
26431967
GCR1_YEASTGCR1physical
27153533
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GCR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-424; SER-429; SER-449;SER-489 AND SER-564, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416; SER-424; SER-429;SER-434; THR-447; SER-449; SER-513 AND SER-516, AND MASS SPECTROMETRY.

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