CACM_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACM_YEAST
• UniProt AC: P80235
• Protein Name: Putative mitochondrial carnitine O-acetyltransferase
• Gene Name: YAT1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 687
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
• Protein Description: Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol..
• Protein Sequence: MPNLKRLPIPPLQDTLNRYLARVEPLQDERQNRRTRRTVLSAENLDALNTLHERLLEYDARLAESNPESSYIEQFWYDAYLLYDATVVLNVNPYFQLQDDPTIKDTPETAAQGPYGAHTVQVRRAARLTTSILKFIRQIRHGTLRTDTVRGKTPLSMDQYERLFGSSRIPPGPGEPSCHLQTDATSHHVVAMYRGQFYWFDVLDTRNEPIFATPEQLEWNLYSIIMDAESAGSGSAPFGVFTTESRRVWSNIRDYLFHADDCTNWRNLKLIDSALFVVCLDDVAFAADQQDELTRSMLCGTSTINLDPHQHQPPLNVQTGTCLNRWYDKLQLIVTKNGKAGINFEHTGVDGHTVLRLATDIYTDSILSFARGVTKNVVDIFSDDDGKPSSSSLASAAHSANLITIPRKLEWRTDNFLQSSLHFAETRISDLISQYEFVNLDFSNYGASHIKTVFKCSPDAFVQQVFQVAYFALYGRFETVYEPAMTKAFQNGRTEAIRSVTGQSKLFVKSLLDQDASDATKIQLLHDACTAHSQITRECSQGLGQDRHLYALYCLWNQWYKDKLELPPIFRDKSWTTMQNNVLSTSNCGNPCLKSFGFGPVTANGFGIGYIIRDHSVSVVVSSRHRQTARFASLMEKSLLEIDRIFKRQQARAAKPAARTTASANTKSEDMKYLLSGYDYFDVSVSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	RTRRTVLSAENLDAL HHHHHHHHHHCHHHH	29.24	27214570
153	Phosphorylation	TDTVRGKTPLSMDQY CCCCCCCCCCCHHHH	32.08	27214570
382	Phosphorylation	KNVVDIFSDDDGKPS CCHHCCCCCCCCCCC	40.23	27214570
389	Phosphorylation	SDDDGKPSSSSLASA CCCCCCCCHHHHHHH	46.46	27214570
390	Phosphorylation	DDDGKPSSSSLASAA CCCCCCCHHHHHHHH	32.26	27214570
391	Phosphorylation	DDGKPSSSSLASAAH CCCCCCHHHHHHHHH	33.44	27214570
392	Phosphorylation	DGKPSSSSLASAAHS CCCCCHHHHHHHHHH	29.87	27214570
517	Phosphorylation	SLLDQDASDATKIQL HHHCCCCCHHHHHHH	35.75	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACM_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACM_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACM_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP9_YEAST	PRP9	genetic	27708008
ERD2_YEAST	ERD2	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
SMC4_YEAST	SMC4	genetic	27708008
BET5_YEAST	BET5	genetic	27708008
OST2_YEAST	OST2	genetic	27708008
MED4_YEAST	MED4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517, AND MASSSPECTROMETRY.
PubMed: 17761666