JEM1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JEM1_YEAST
• UniProt AC: P40358
• Protein Name: DnaJ-like chaperone JEM1
• Gene Name: JEM1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 645
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Nucleus membrane .
• Protein Description: Acts as a DnaJ-like chaperone required for nuclear membrane fusion during mating..
• Protein Sequence: MILISGYCLLVYSVILPVLISASKLCDLAELQRLNKNLKVDTESLPKYQWIAGQLEQNCMTADPASENMSDVIQLANQIYYKIGLIQLSNDQHLRAINTFEKIVFNETYKGSFGKLAEKRLQELYVDFGMWDKVHQKDDQYAKYLSLNETIRNKISSKDVSVEEDISELLRITPYDVNVLSTHIDVLFHKLAEEIDVSLAAAIILDYETILDKHLASLSIDTRLSIHYVISVLQTFVLNSDASFNIRKCLSIDMDYDKCKKLSLTISKLNKVNPSKRQILDPATYAFENKKFRSWDRIIEFYLKDKKPFITPMKILNKDTNFKNNYFFLEEIIKQLIEDVQLSRPLAKNLFEDPPITDGFVKPKSYYHTDYLVYIDSILCQASSMSPDVKRAKLAAPFCKKSLRHSLTLETWKHYQDAKSEQKPLPETVLSDVWNSNPHLLMYMVNSILNKSRSKPHSQFKKQLYDQINKFFQDNGLSESTNPYVMKNFRLLQKQLQTYKEHKHRNFNQQYFQQQQQQQQHQRHQAPPAAPNYDPKKDYYKILGVSPSASSKEIRKAYLNLTKKYHPDKIKANHNDKQESIHETMSQINEAYETLSDDDKRKEYDLSRSNPRRNTFPQGPRQNNMFKNPGSGFPFGNGFKMNFGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
304	Acetylation	RIIEFYLKDKKPFIT HHHHHHHCCCCCCCC	57.00	24489116
592	Phosphorylation	MSQINEAYETLSDDD HHHHHHHHHHCCCCH	11.85	28132839
631	Phosphorylation	NMFKNPGSGFPFGNG CCCCCCCCCCCCCCC	38.22	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JEM1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JEM1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JEM1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPS3_YEAST	MPS3	physical	12493774
SCJ1_YEAST	SCJ1	genetic	9148890
MKAR_YEAST	IFA38	genetic	16269340
SCJ1_YEAST	SCJ1	genetic	16269340
DS1P1_YEAST	LCB3	genetic	16269340
GRP78_YEAST	KAR2	physical	18754794
SCJ1_YEAST	SCJ1	genetic	18754794
MPS3_YEAST	MPS3	physical	18754794
MPS3_YEAST	MPS3	genetic	18754794
CHD1_YEAST	CHD1	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
KEX1_YEAST	KEX1	genetic	20093466
MON1_YEAST	MON1	genetic	20093466
MTL1_YEAST	MTL1	genetic	20093466
PEF1_YEAST	PEF1	genetic	20093466
UBR1_YEAST	UBR1	genetic	20093466
LRP1_YEAST	LRP1	genetic	20093466
APQ12_YEAST	APQ12	genetic	20093466
CSF1_YEAST	CSF1	genetic	20093466
ALAM_YEAST	ALT1	genetic	20093466
SCJ1_YEAST	SCJ1	genetic	20093466
FABD_YEAST	MCT1	genetic	20093466
GRP78_YEAST	KAR2	physical	20430885
MGA2_YEAST	MGA2	genetic	19325107
MPD1_YEAST	MPD1	genetic	19325107
LCL2_YEAST	LCL2	genetic	19325107
SSB1_YEAST	SSB1	physical	22940862
DED1_YEAST	DED1	physical	22940862
JEM1_YEAST	JEM1	physical	22940862
SCJ1_YEAST	SCJ1	genetic	24627482
ARO8_YEAST	ARO8	genetic	27708008
CND2_YEAST	BRN1	genetic	27708008
SLD5_YEAST	SLD5	genetic	27708008
CDC4_YEAST	CDC4	genetic	27708008
RSC8_YEAST	RSC8	genetic	27708008
TEL2_YEAST	TEL2	genetic	27708008
CBF3B_YEAST	CEP3	genetic	27708008
MED10_YEAST	NUT2	genetic	27708008
CHD1_YEAST	CHD1	genetic	27708008
MON1_YEAST	MON1	genetic	27708008
VAM7_YEAST	VAM7	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
PEF1_YEAST	PEF1	genetic	27708008
TBP7_YEAST	YTA7	genetic	27708008
LRP1_YEAST	LRP1	genetic	27708008
ILM1_YEAST	ILM1	genetic	27708008
ALAM_YEAST	ALT1	genetic	27708008
LIPB_YEAST	LIP2	genetic	27708008
SCJ1_YEAST	SCJ1	genetic	27708008
PHO23_YEAST	PHO23	genetic	27708008
FABD_YEAST	MCT1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.