dbPTM

ARG56_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARG56_YEAST
UniProt AC	Q01217
Protein Name	Protein ARG5,6, mitochondrial
Gene Name	ARG5,6
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	863
Subcellular Localization	Mitochondrion.
Protein Description
Protein Sequence	MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVAFTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKVGGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEHTMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPIEASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTGEKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFTDSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFVSYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSENDANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFANKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSRELKGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSKIIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGLPTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQWFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGGFKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSASLLVST -----CCCHHHEEEC	29.23	19823750
5	Phosphorylation	---MPSASLLVSTKR ---CCCHHHEEECCC	26.94	19823750
9	Phosphorylation	PSASLLVSTKRLNAS CCHHHEEECCCCCHH	28.34	19823750
10	Phosphorylation	SASLLVSTKRLNASK CHHHEEECCCCCHHH	16.83	19823750
16	Phosphorylation	STKRLNASKFQKFVS ECCCCCHHHHHHHHH	32.69	19823750
23	Phosphorylation	SKFQKFVSSLNKSTI HHHHHHHHHCCCCCC	32.04	26447709
24	Phosphorylation	KFQKFVSSLNKSTIA HHHHHHHHCCCCCCC	30.57	26447709
28	Phosphorylation	FVSSLNKSTIAGFAS HHHHCCCCCCCEEEC	24.79	26447709
29	Phosphorylation	VSSLNKSTIAGFASV HHHCCCCCCCEEECC	19.22	26447709
35	Phosphorylation	STIAGFASVPLRAPP CCCCEEECCCCCCCC	23.23	26447709
205	Acetylation	FTADYLDKDKYKLVG EEHHHCCCCCCEEEE	54.23	24489116
265	Acetylation	ARVFEPLKIVYLNEK HHHCCCEEEEEECCC	40.62	24489116
272	Succinylation	KIVYLNEKGGIINGS EEEEECCCCCEECCC	62.45	23954790
272	Acetylation	KIVYLNEKGGIINGS EEEEECCCCCEECCC	62.45	24489116
303	Acetylation	LMKQSWVKYGTKLKI HHHHHHHHHCCHHCH	31.53	22865919
314	Acetylation	KLKIREIKELLDYLP HHCHHHHHHHHHHCC	37.24	24489116
358	Phosphorylation	GYKLVKRSSIGEFPS CEEEEEHHCCCCCCC	22.16	29136822
359	Phosphorylation	YKLVKRSSIGEFPSA EEEEEHHCCCCCCCH	38.35	17330950
365	Phosphorylation	SSIGEFPSADALRKA HCCCCCCCHHHHHHH	44.07	19823750
554	Acetylation	GARGYTGKNLVSLIN ECCCCCCCCHHHHHC	39.03	24489116
709	Acetylation	GYSGAGTKPSPKNDP CCCCCCCCCCCCCCH	42.45	24489116
711	Phosphorylation	SGAGTKPSPKNDPKF CCCCCCCCCCCCHHH	50.49	27017623
717	Acetylation	PSPKNDPKFLNNNLI CCCCCCHHHHCCCCH	66.40	24489116
814	Acetylation	GVVIGGFKLNDAEDR EEEECEEECCCCCCC	50.05	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARG56_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARG56_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARG56_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LSM12_YEAST	LSM12	physical	16554755
CAN1_YEAST	CAN1	genetic	16941010
GAP1_YEAST	GAP1	genetic	16941010
GAP1_YEAST	GAP1	genetic	21526172

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARG56_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-359, ANDMASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, AND MASSSPECTROMETRY.	17330950 [Abstract]