| UniProt ID | SP381_YEAST | |
|---|---|---|
| UniProt AC | P38282 | |
| Protein Name | Pre-mRNA-splicing factor SPP381 | |
| Gene Name | SPP381 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 291 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA.. | |
| Protein Sequence | MSFRHFKRRLDTSSADESSSADEEHPDQNVSLTEKSASLSHSDLGGEILNGTGKNRTPNDGQESNESDGSPESDESPESEESSDNSDSSDSDDMRPLPRPLFMKKKANNLQKATKIDQPWNAQDDARVLQTKKENMIKNIDKANQVAKNYETMKLRLNTNYSTNEELIKQCLLLDDNDEVDSEKERQKWFERQNERKQKHRRIQLAKQRESEEYEAKRFEAMQKGKDGNTKYDVILDKEKEKLDHKKQRSAEKVEKSHNNNRYKITRTKNVEFGDLGKNSRDYEETEYSVI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | HFKRRLDTSSADESS HHHHHCCCCCCCCCC | 29.22 | 21551504 | |
| 13 | Phosphorylation | FKRRLDTSSADESSS HHHHCCCCCCCCCCC | 24.16 | 19795423 | |
| 14 | Phosphorylation | KRRLDTSSADESSSA HHHCCCCCCCCCCCC | 41.66 | 21551504 | |
| 18 | Phosphorylation | DTSSADESSSADEEH CCCCCCCCCCCCCCC | 30.09 | 23749301 | |
| 19 | Phosphorylation | TSSADESSSADEEHP CCCCCCCCCCCCCCC | 27.74 | 19795423 | |
| 20 | Phosphorylation | SSADESSSADEEHPD CCCCCCCCCCCCCCC | 49.36 | 19795423 | |
| 31 | Phosphorylation | EHPDQNVSLTEKSAS CCCCCCCCCCHHHHC | 36.80 | 19795423 | |
| 33 | Phosphorylation | PDQNVSLTEKSASLS CCCCCCCCHHHHCCC | 33.58 | 19795423 | |
| 36 | Phosphorylation | NVSLTEKSASLSHSD CCCCCHHHHCCCHHH | 19.50 | 22369663 | |
| 38 | Phosphorylation | SLTEKSASLSHSDLG CCCHHHHCCCHHHHC | 37.18 | 22369663 | |
| 40 | Phosphorylation | TEKSASLSHSDLGGE CHHHHCCCHHHHCCC | 20.60 | 22369663 | |
| 42 | Phosphorylation | KSASLSHSDLGGEIL HHHCCCHHHHCCCCC | 31.02 | 22369663 | |
| 52 | Phosphorylation | GGEILNGTGKNRTPN CCCCCCCCCCCCCCC | 43.86 | 22369663 | |
| 162 | Phosphorylation | LRLNTNYSTNEELIK EECCCCCCCCHHHHH | 27.16 | 30377154 | |
| 182 | Phosphorylation | DDNDEVDSEKERQKW CCCCCCCCHHHHHHH | 56.60 | 23749301 | |
| 231 | Acetylation | KGKDGNTKYDVILDK CCCCCCCCEEEEECH | 43.37 | 24489116 | |
| 278 | Acetylation | VEFGDLGKNSRDYEE EECCCCCCCCCCCCC | 60.07 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SP381_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SP381_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SP381_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38 AND SER-40, AND MASSSPECTROMETRY. | |
